scholarly journals Merotelic attachments allow alignment and stabilization of chromatids in meiosis II oocytes

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Anna Kouznetsova ◽  
Abrahan Hernández-Hernández ◽  
Christer Höög
Keyword(s):  
Merotelic Attachments

scholarly journals Merotelic attachments and non-homologous end joining are the basis of chromosomal instability

Cell Division ◽  
2010 ◽  
Vol 5 (1) ◽  
pp. 13 ◽  
Author(s):  
Astrid Guerrero ◽  
Carlos Martínez-A ◽  
Karel HM van Wely
Keyword(s):  
Chromosomal Instability ◽  
End Joining ◽  
Non Homologous End Joining ◽  
Merotelic Attachments

scholarly journals Chromosomal instability and aneuploidy: a conundrum in cancer evolution

2018 ◽  
Vol 1 ◽  
pp. 28-32
Author(s):  
Jasmin Ali
Keyword(s):  
Chromosomal Instability ◽  
Spindle Assembly Checkpoint ◽  
Spindle Assembly ◽  
Current Understanding ◽  
Cancer Therapies ◽  
Cancer Evolution ◽  
Hallmarks Of Cancer ◽  
Underlying Mechanisms ◽  
Merotelic Attachments

Chromosomal instability (CIN), defined as an increased rate of gain or loss of whole chromosomes, leads to aneuploid cells, which are cells that display an abnormal number of chromosomes. Both CIN and aneuploidy are hallmarks of cancer, yet the underlying mechanisms of CIN and aneuploidy and their impact on tumourigenesis have remained poorly defined. Although multiple mechanisms have been proposed to explain the role of CIN and aneuploidy in tumourigenesis, this review focuses on three principal pathways leading to CIN: spindle assembly checkpoint defects, merotelic attachments, and cohesion defects. Here, we provide a brief overview of the current understanding of the roles of these mechanisms in CIN and aneuploidy. We also present emerging evidence that contradicts the importance of certain mechanisms in cancer evolution. A clearer understanding of these fundamental pathways could prove to be helpful in developing effective cancer therapies.

scholarly journals Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Damian Dudka ◽  
Anna Noatynska ◽  
Chris A. Smith ◽  
Nicolas Liaudet ◽  
Andrew D. McAinsh ◽  
...  
Keyword(s):  
Merotelic Attachments
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