scholarly journals Role of Rab11 in planar cell polarity and apical constriction during vertebrate neural tube closure

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Olga Ossipova ◽  
Kyeongmi Kim ◽  
Blue B. Lake ◽  
Keiji Itoh ◽  
Andriani Ioannou ◽  
...  
Keyword(s):  
Cell Polarity ◽  
Neural Tube ◽  
Planar Cell Polarity ◽  
Neural Tube Closure ◽  
Apical Constriction ◽  
Tube Closure

Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds

2020 ◽  
Author(s):  
Izabela Kowalczyk ◽  
Chanjae Lee ◽  
Elisabeth Schuster ◽  
Josefine Hoeren ◽  
Valentina Trivigno ◽  
...  
Keyword(s):  
Cell Polarity ◽  
Neural Tube ◽  
Planar Cell Polarity ◽  
Adaptor Proteins ◽  
Neural Tube Closure ◽  
Model Organisms ◽  
Loss Of Function ◽  
Functional Interaction ◽  
Apical Constriction ◽  
Tube Closure

AbstractRecent studies have revealed that pathogenic mutations in the endocytic receptor LRP2 in humans are associated with severe neural tube closure defects (NTDs) such as anencephaly and spina bifida. Here, we combined analysis of neural tube closure in mouse and in the African Clawed Frog Xenopus laevis to elucidate the etiology of Lrp2-related NTDs. Lrp2 loss-of-function (LOF) impaired neuroepithelial morphogenesis, culminating in NTDs that impeded anterior neural plate folding and neural tube closure in both model organisms. Loss of Lrp2 severely affected apical constriction as well as proper localization of the core planar cell polarity (PCP) protein Vangl2, demonstrating a highly conserved role of the receptor in these processes essential for neural tube formation. In addition, we identified a novel functional interaction of Lrp2 with the intracellular adaptor proteins Shroom3 and Gipc1 in the developing forebrain. Our data suggest that during neurulation, motifs within the intracellular domain of Lrp2 function as a hub that orchestrates endocytic membrane removal for efficient apical constriction as well as PCP component trafficking in a temporospatial manner.Summary statementAnalysis of neurulation in mouse and Xenopus reveals novel roles for Lrp2-mediated endocytosis in orchestrating apical constriction and planar cell polarity essential for neural tube closure.

scholarly journals Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity

Development ◽  
2013 ◽  
Vol 140 (14) ◽  
pp. 3008-3017 ◽  
Author(s):  
N. Escobedo ◽  
O. Contreras ◽  
R. Munoz ◽  
M. Farias ◽  
H. Carrasco ◽  
...  
Keyword(s):  
Cell Polarity ◽  
Neural Tube ◽  
Planar Cell Polarity ◽  
Neural Tube Closure ◽  
Tube Closure

scholarly journals Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds

Development ◽  
2021 ◽  
Vol 148 (2) ◽  
pp. dev195008
Author(s):  
Izabela Kowalczyk ◽  
Chanjae Lee ◽  
Elisabeth Schuster ◽  
Josefine Hoeren ◽  
Valentina Trivigno ◽  
...  
Keyword(s):  
Neural Tube ◽  
Planar Cell Polarity ◽  
Adaptor Proteins ◽  
Tube Formation ◽  
Neural Tube Closure ◽  
Model Organisms ◽  
Loss Of Function ◽  
Functional Interaction ◽  
Apical Constriction ◽  
Tube Closure

ABSTRACTPathogenic mutations in the endocytic receptor LRP2 in humans are associated with severe neural tube closure defects (NTDs) such as anencephaly and spina bifida. Here, we have combined analysis of neural tube closure in mouse and in the African Clawed Frog Xenopus laevis to elucidate the etiology of Lrp2-related NTDs. Lrp2 loss of function impaired neuroepithelial morphogenesis, culminating in NTDs that impeded anterior neural plate folding and neural tube closure in both model organisms. Loss of Lrp2 severely affected apical constriction as well as proper localization of the core planar cell polarity (PCP) protein Vangl2, demonstrating a highly conserved role of the receptor in these processes, which are essential for neural tube formation. In addition, we identified a novel functional interaction of Lrp2 with the intracellular adaptor proteins Shroom3 and Gipc1 in the developing forebrain. Our data suggest that, during neurulation, motifs within the intracellular domain of Lrp2 function as a hub that orchestrates endocytic membrane removal for efficient apical constriction, as well as PCP component trafficking in a temporospatial manner.

scholarly journals 03-P026 Retinoic acid – planar cell polarity crosstalk during neural tube closure

2009 ◽  
Vol 126 ◽  
pp. S75
Author(s):  
Ioana Laura Tuduce ◽  
Purushthama Tata Rao ◽  
Xianling Zhao ◽  
Gregg Duester ◽  
Michael Kühl ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Cell Polarity ◽  
Neural Tube ◽  
Planar Cell Polarity ◽  
Neural Tube Closure ◽  
Tube Closure
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