scholarly journals A mutation in the enzyme monoamine oxidase explains part of the Astyanax cavefish behavioural syndrome

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Yannick Elipot ◽  
Hélène Hinaux ◽  
Jacques Callebert ◽  
Jean-Marie Launay ◽  
Maryline Blin ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Behavioural Syndrome ◽  
Enzyme Monoamine Oxidase

A Clinical and Biochemical Study of Monoamine Oxidase Inhibition in Depressed Patients

1961 ◽  
Vol 107 (447) ◽  
pp. 239-243 ◽  
Author(s):  
W. G. Dewhurst ◽  
C. M. B. Pare
Keyword(s):  
Monoamine Oxidase ◽  
Clinical Application ◽  
Biochemical Study ◽  
Toxic Effects ◽  
Mao Inhibitors ◽  
Monoamine Oxidase Inhibition ◽  
Depressed Patients ◽  
Depressant Action ◽  
Oxidase Inhibition ◽  
Enzyme Monoamine Oxidase

The discovery that iproniazid benefits certain subjects with depression, linked with the demonstration that it inhibits the enzyme monoamine oxidase (MAO), led to the hypothesis that inhibition of MAO was the essential mechanism by which iproniazid caused relief of symptoms (Pletscher, 1959). Iproniazid, unfortunately, can produce serious toxic effects, particularly on the liver (Pare and Sandler, 1959), and this has limited its clinical application. For this reason a search has been made for MAO inhibitors with an effective anti-depressant action yet without the serious toxic effects of iproniazid. Among the newer compounds for which such claims have been made is N-isonicotinoyl (-N-N-benzylcarboxamidoethyl) hydrazine or Nialamide.

Isoflavones prevent oxidative stress and inhibit the activity of the enzyme monoamine oxidase in vitro

2019 ◽  
Vol 46 (2) ◽  
pp. 2285-2292 ◽  
Author(s):  
Izaviany da Silva Schmitz ◽  
Larissa Finger Schaffer ◽  
Alcindo Busanello ◽  
Catiuscia Molz de Freitas ◽  
Roselei Fachinetto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Monoamine Oxidase ◽  
Enzyme Monoamine Oxidase

Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

2019 ◽  
Vol 55 (88) ◽  
pp. 13267-13270 ◽  
Author(s):  
Won Young Kim ◽  
Miae Won ◽  
Abbas Salimi ◽  
Amit Sharma ◽  
Jong Hyeon Lim ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Monoamine Oxidase ◽  
Cancer Imaging ◽  
Monoamine Oxidase A ◽  
Mitochondrial Enzyme ◽  
Mao A ◽  
Enzyme Monoamine Oxidase

Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells.

Developmental Aspects of the Monoamine-Degrading Enzyme Monoamine Oxidase

1992 ◽  
Vol 18 (3-4) ◽  
pp. 191-200 ◽  
Author(s):  
M. Strolin Benedetti ◽  
P. Dosiert ◽  
K.F. Tipton
Keyword(s):  
Monoamine Oxidase ◽  
Degrading Enzyme ◽  
Enzyme Monoamine Oxidase

Interrelationship between the inhibition of the activity of the enzyme monoamine oxidase and the anesthetizing activity of certain compounds

1977 ◽  
Vol 11 (2) ◽  
pp. 195-198
Author(s):  
V. Ya. Grinshtein ◽  
A. A. Prikulis ◽  
B. A. Grinberga ◽  
Ya. Ya. Shusters ◽  
A. P. Skutelis
Keyword(s):  
Monoamine Oxidase ◽  
Enzyme Monoamine Oxidase

Directed Evolution of the Enzyme Monoamine Oxidase (MAO-N): Highly Efficient Chemo-enzymatic Deracemisation of the Alkaloid (±)-Crispine A

ChemCatChem ◽  
2012 ◽  
Vol 4 (9) ◽  
pp. 1259-1261 ◽  
Author(s):  
Ian Rowles ◽  
Kirk J. Malone ◽  
Laura L. Etchells ◽  
Simon C. Willies ◽  
Nicholas J. Turner
Keyword(s):  
Monoamine Oxidase ◽  
Directed Evolution ◽  
Highly Efficient ◽  
Enzyme Monoamine Oxidase

scholarly journals Enzymatic oxidation of substituted tryptamines catalysed by monoamine oxidase

Nukleonika ◽  
2014 ◽  
Vol 59 (3) ◽  
pp. 91-95 ◽  
Author(s):  
Sylwia Dragulska ◽  
Marianna Kańska
Keyword(s):  
Monoamine Oxidase ◽  
Isotope Effects ◽  
Kinetic Studies ◽  
Monoamine Oxidase A ◽  
Enzymatic Oxidation ◽  
Mao A ◽  
Deuterium Isotope Effects ◽  
Enzymatic Decarboxylation ◽  
Enzyme Monoamine Oxidase

Abstract The enzymatic deamination of 5-fl uorotryptamine and 5-hydroxytryptamine, 5-HT, catalysed by enzyme monoamine oxidase A (MAO-A, EC 1.4.3.4) was investigated using the kinetic (KIE) and solvent (SIE) isotope effects methods. The numerical values of deuterium isotope effects in the (1R) positions of 5-F-tryptamine were determined using non-competitive spectrophotomeric method. Isotopologue 5-F-[(1R)- -2H]-tryptamine, needed for kinetic studies was obtained by enzymatic decarboxylation of 5´-fl uoro-L-tryptophan, 5´-F-L-Trp, in fully deuteriated medium.

A Controlled Study of the Effectiveness of Nialamide (“Niamid”) in Schizophrenia

1961 ◽  
Vol 107 (448) ◽  
pp. 572-574
Author(s):  
J. G. Hegarty ◽  
A. R. Dabbs ◽  
R. T. St. Blaize-Molony
Keyword(s):  
Side Effects ◽  
Monoamine Oxidase ◽  
Catalytic Oxidation ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor ◽  
Controlled Study ◽  
Enzyme Monoamine Oxidase

Nialamide is claimed to inhibit the activity of the enzyme monoamine oxidase which is known to be responsible for the breakdown by catalytic oxidation of various amines, e.g. serotonin and norepinephrine. It has been suggested that depression may be associated with inadequate levels of serotonin and/or norepinephrine and that the administration of a monoamine oxidase inhibitor should rationally help to relieve depression. No serious side-effects have been reported in the available literature except that agitated patients might become somewhat more agitated and overactive.

THE REGULATION OF MONOAMINE OXIDASE ACTIVITY BY ADRENAL CORTICAL STEROIDS

1973 ◽  
Vol 73 (3) ◽  
pp. 509-517 ◽  
Author(s):  
H. Parvez ◽  
S. Parvez
Keyword(s):  
Monoamine Oxidase ◽  
Significant Rise ◽  
Tissue Homogenate ◽  
Limiting Factor ◽  
Hydrocortisone Administration ◽  
Mao Activity ◽  
Rate Limiting ◽  
The Brain ◽  
Adrenalectomized Rats ◽  
Enzyme Monoamine Oxidase

ABSTRACT The activity of the enzyme monoamine oxidase (MAO) in the brain, heart, liver and spleen of rats 10 weeks after adrenalectomy was determined. Another group of adrenalectomized rats received 5 mg of hydrocortisone daily for the period of 10 days and their MAO activity was compared with that of control adrenalectomized rats. There was a significant rise in MAO activity following adrenalectomy in the tissue homogenate, mitochondrial and supernatant fractions of all the organs studied. Hydrocortisone administration decreased MAO activity to the level of normal rats. These results suggest that corticoids serve as a rate limiting factor for the activity of the enzyme MAO. This hypothesis was further tested in normal rats by blocking the biosynthesis of glucocorticoids with Metopirone®. Four hours after a single injection of 75 mg Metopirone the cerebral, hepatic and cardiac MAO showed marked increases from control levels. These results suggest that adrenal cortical steroids present in the circulation of normal animals regulate the activity of the enzyme MAO in most organs.

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