scholarly journals An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Roberta Azzarelli ◽  
Emilie Pacary ◽  
Ritu Garg ◽  
Patricia Garcez ◽  
Debbie van den Berg ◽  
...  
Keyword(s):  
Cortical Neuron ◽  
Neuron Migration ◽  
Rhoa Activity ◽  
Antagonistic Interaction

scholarly journals C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment

Development ◽  
2008 ◽  
Vol 135 (12) ◽  
pp. 2139-2149 ◽  
Author(s):  
A. K. Voss ◽  
J. M. Britto ◽  
M. P. Dixon ◽  
B. N. Sheikh ◽  
C. Collin ◽  
...  
Keyword(s):  
Cortical Neuron ◽  
Glial Cell ◽  
Cell Attachment ◽  
Radial Glial Cell ◽  
Neuron Migration ◽  
Radial Glial

scholarly journals Novel genetic tools facilitate the study of cortical neuron migration

2015 ◽  
Vol 27 (1-2) ◽  
pp. 8-16 ◽  
Author(s):  
Megan Cionni ◽  
Chelsea Menke ◽  
Rolf W. Stottmann
Keyword(s):  
Cortical Neuron ◽  
Neuron Migration ◽  
Genetic Tools

scholarly journals Dynein activating adaptor BICD2 controls radial migration of upper-layer cortical neurons in vivo

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Lena Will ◽  
Sybren Portegies ◽  
Jasper van Schelt ◽  
Merel van Luyk ◽  
Dick Jaarsma ◽  
...  
Keyword(s):  
Cortical Neuron ◽  
Cortical Neurons ◽  
Cortical Development ◽  
Adaptor Protein ◽  
Cortical Plate ◽  
Neuron Migration ◽  
Knock Out ◽  
Radial Migration

Abstract For the proper organization of the six-layered mammalian neocortex it is required that neurons migrate radially from their place of birth towards their designated destination. The molecular machinery underlying this neuronal migration is still poorly understood. The dynein-adaptor protein BICD2 is associated with a spectrum of human neurological diseases, including malformations of cortical development. Previous studies have shown that knockdown of BICD2 interferes with interkinetic nuclear migration in radial glial progenitor cells, and that Bicd2-deficient mice display an altered laminar organization of the cerebellum and the neocortex. However, the precise in vivo role of BICD2 in neocortical development remains unclear. By comparing cell-type specific conditional Bicd2 knock-out mice, we found that radial migration in the cortex predominantly depends on BICD2 function in post-mitotic neurons. Neuron-specific Bicd2 cKO mice showed severely impaired radial migration of late-born upper-layer neurons. BICD2 depletion in cortical neurons interfered with proper Golgi organization, and neuronal maturation and survival of cortical plate neurons. Single-neuron labeling revealed a specific role of BICD2 in bipolar locomotion. Rescue experiments with wildtype and disease-related mutant BICD2 constructs revealed that a point-mutation in the RAB6/RANBP2-binding-domain, associated with cortical malformation in patients, fails to restore proper cortical neuron migration. Together, these findings demonstrate a novel, cell-intrinsic role of BICD2 in cortical neuron migration in vivo and provide new insights into BICD2-dependent dynein-mediated functions during cortical development.

scholarly journals Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration

Neuron ◽  
2017 ◽  
Vol 93 (2) ◽  
pp. 348-361 ◽  
Author(s):  
Debbie L.C. van den Berg ◽  
Roberta Azzarelli ◽  
Koji Oishi ◽  
Ben Martynoga ◽  
Noelia Urbán ◽  
...  
Keyword(s):  
Cortical Neuron ◽  
Neuron Migration

scholarly journals Oscillation of Cdc20-APC/C-mediated CAMDI stability is critical for cortical neuron migration

2021 ◽  
pp. 100986
Author(s):  
Shohei Okuda ◽  
Mariko Sato ◽  
Saho Kato ◽  
Shun Nagashima ◽  
Ryoko Inatome ◽  
...  
Keyword(s):  
Cortical Neuron ◽  
Neuron Migration

scholarly journals Carboxypeptidase E Independently Changes Microtubule Glutamylation, Dendritic Branching, and Neuronal Migration

ASN NEURO ◽  
2022 ◽  
Vol 14 ◽  
pp. 175909142110627
Author(s):  
Chen Liang ◽  
Damien Carrel ◽  
Nisha K. Singh ◽  
Liam L. Hiester ◽  
Isabelle Fanget ◽  
...  
Keyword(s):  
Cortical Neuron ◽  
Neuronal Migration ◽  
Critical Role ◽  
Cortical Plate ◽  
Binding Motif ◽  
Wild Type ◽  
Dendrite Morphology ◽  
Neuron Migration ◽  
Carboxypeptidase E ◽  
The Impact

Neuronal migration and dendritogenesis are dependent on dynamic changes to the microtubule (MT) network. Among various factors that regulate MT dynamics and stability, post-translational modifications (PTMs) of MTs play a critical role in conferring specificity of regulatory protein binding to MTs. Thus, it is important to understand the regulation of PTMs during brain development as multiple developmental processes are dependent on MTs. In this study, we identified that carboxypeptidase E (CPE) changes tubulin polyglutamylation, a major PTM in the brain, and we examine the impact of CPE-mediated changes to polyglutamylation on cortical neuron migration and dendrite morphology. We show, for the first time, that overexpression of CPE increases the level of polyglutamylated α-tubulin while knockdown decreases the level of polyglutamylation. We also demonstrate that CPE-mediated changes to polyglutamylation are dependent on the CPE zinc-binding motif and that this motif is necessary for CPE action on p150Glued localization. However, overexpression of a CPE mutant that does not increase MT glutamylation mimics the effects of overexpression of wild type CPE on dendrite branching. Furthermore, although overexpression of wild type CPE does not alter cortical neuron migration, overexpression of the mutant may act in a dominant-negative manner as it decreases the number of neurons that reach the cortical plate (CP), as we previously reported for CPE knockdown. Overall, our data suggest that CPE changes MT glutamylation and redistribution of p150Glued and that this function of CPE is independent of its role in shaping dendrite development but plays a partial role in regulating cortical neuron migration.

Regulation of Cortical Neuron Migration by the Reelin Signaling Pathway

2011 ◽  
Vol 36 (7) ◽  
pp. 1270-1279 ◽  
Author(s):  
Takao Honda ◽  
Kazuma Kobayashi ◽  
Katsuhiko Mikoshiba ◽  
Kazunori Nakajima
Keyword(s):  
Cortical Neuron ◽  
Signaling Pathway ◽  
Neuron Migration ◽  
Reelin Signaling
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