scholarly journals Erratum: Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Iebe Rossey ◽  
Morgan S. A. Gilman ◽  
Stephanie C. Kabeche ◽  
Koen Sedeyn ◽  
Daniel Wrapp ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Fusion Protein ◽  
Single Domain ◽  
Virus Fusion ◽  
Single Domain Antibodies ◽  
Syncytial Virus

scholarly journals Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Iebe Rossey ◽  
Morgan S. A. Gilman ◽  
Stephanie C. Kabeche ◽  
Koen Sedeyn ◽  
Daniel Wrapp ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Fusion Protein ◽  
Respiratory Tract Infections ◽  
Antiviral Agents ◽  
Single Domain ◽  
Neutralizing Activity ◽  
Inflammatory Monocytes ◽  
Single Domain Antibodies ◽  
Syncytial Virus ◽  
Tract Infections

Abstract Human respiratory syncytial virus (RSV) is the main cause of lower respiratory tract infections in young children. The RSV fusion protein (F) is highly conserved and is the only viral membrane protein that is essential for infection. The prefusion conformation of RSV F is considered the most relevant target for antiviral strategies because it is the fusion-competent form of the protein and the primary target of neutralizing activity present in human serum. Here, we describe two llama-derived single-domain antibodies (VHHs) that have potent RSV-neutralizing activity and bind selectively to prefusion RSV F with picomolar affinity. Crystal structures of these VHHs in complex with prefusion F show that they recognize a conserved cavity formed by two F protomers. In addition, the VHHs prevent RSV replication and lung infiltration of inflammatory monocytes and T cells in RSV-challenged mice. These prefusion F-specific VHHs represent promising antiviral agents against RSV.

Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses

Immunity ◽  
2021 ◽  
Author(s):  
Maryam Mukhamedova ◽  
Daniel Wrapp ◽  
Chen-Hsiang Shen ◽  
Morgan S.A. Gilman ◽  
Tracy J. Ruckwardt ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Fusion Protein ◽  
Antibody Responses ◽  
Virus Fusion ◽  
Syncytial Virus

scholarly journals Analysis of the Respiratory Syncytial Virus Fusion Protein Using Monoclonal and Polyclonal Antibodies

1986 ◽  
Vol 67 (3) ◽  
pp. 505-513 ◽  
Author(s):  
E. E. Walsh ◽  
P. J. Cote ◽  
B. F. Fernie ◽  
J. J. Schlesinger ◽  
M. W. Brandriss
Keyword(s):  
Respiratory Syncytial Virus ◽  
Fusion Protein ◽  
Polyclonal Antibodies ◽  
Virus Fusion ◽  
Syncytial Virus

The Design of Vaccines Based on the Shielding of Antigenic Site Ø of a Respiratory Syncytial Virus Fusion Protein Immunogen

2020 ◽  
pp. 2000714
Author(s):  
Steven J. Frey ◽  
Chad Varner ◽  
Ammar Arsiwala ◽  
Michael G. Currier ◽  
Martin L. Moore ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Fusion Protein ◽  
Antigenic Site ◽  
Virus Fusion ◽  
Syncytial Virus

scholarly journals Inferior immunogenicity and efficacy of respiratory syncytial virus fusion protein-based subunit vaccine candidates in aged versus young mice

PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0188708 ◽  
Author(s):  
Corinne Cayatte ◽  
Angie Snell Bennett ◽  
Gaurav Manohar Rajani ◽  
Leigh Hostetler ◽  
Sean K. Maynard ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Fusion Protein ◽  
Subunit Vaccine ◽  
Vaccine Candidates ◽  
Virus Fusion ◽  
Syncytial Virus ◽  
Young Mice

scholarly journals Molecular Epidemiology and Phylodynamics of the Human Respiratory Syncytial Virus Fusion Protein in Northern Taiwan

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e64012 ◽  
Author(s):  
Hsin Chi ◽  
Hsin-Fu Liu ◽  
Li-Chuan Weng ◽  
Nai-Yu Wang ◽  
Nan-Chang Chiu ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Fusion Protein ◽  
Molecular Epidemiology ◽  
Human Respiratory Syncytial Virus ◽  
Virus Fusion ◽  
Syncytial Virus ◽  
Northern Taiwan
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