scholarly journals Mir-132/212 is required for maturation of binocular matching of orientation preference and depth perception

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Raffaele Mazziotti ◽  
Laura Baroncelli ◽  
Nicholas Ceglia ◽  
Gabriele Chelini ◽  
Grazia Della Sala ◽  
...  
Keyword(s):  
Depth Perception ◽  
Orientation Preference ◽  
Binocular Matching

scholarly journals Closing the Critical Period Is Required for the Maturation of Binocular Integration in Mouse Primary Visual Cortex

2021 ◽  
Vol 15 ◽  
Author(s):  
Jiangping Chan ◽  
Xiangwen Hao ◽  
Qiong Liu ◽  
Jianhua Cang ◽  
Yu Gu
Keyword(s):  
Visual Cortex ◽  
Mouse Model ◽  
Primary Visual Cortex ◽  
Depth Perception ◽  
Critical Period ◽  
Visual Experience ◽  
Extracellular Recording ◽  
Molecular Assay ◽  
Binocular Matching

Binocular matching of orientation preference between the two eyes is a common form of binocular integration that is regarded as the basis for stereopsis. How critical period plasticity enables binocular matching under the guidance of normal visual experience has not been fully demonstrated. To investigate how critical period closure affects the binocular matching, a critical period prolonged mouse model was constructed through the administration of bumetanide, an NKCC1 transporter antagonist. Using acute in vivo extracellular recording and molecular assay, we revealed that binocular matching was transiently disrupted due to heightened plasticity after the normal critical period, together with an increase in the density of spines and synapses, and the upregulation of GluA1 expression. Diazepam (DZ)/[(R, S)-3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP)] could reclose the extended critical period, and rescue the deficits in binocular matching. Furthermore, the extended critical period, alone, with normal visual experience is sufficient for the completion of binocular matching in amblyopic mice. Similarly, prolonging the critical period into adulthood by knocking out Nogo-66 receptor can prevent the normal maturation of binocular matching and depth perception. These results suggest that maintaining an optimal plasticity level during adolescence is most beneficial for the systemic maturation. Extending the critical period provides new clues for the maturation of binocular vision and may have critical implications for the treatment of amblyopia.

scholarly journals Environmental Enrichment Rescues Binocular Matching of Orientation Preference in Mice that Have a Precocious Critical Period

Neuron ◽  
2013 ◽  
Vol 80 (1) ◽  
pp. 198-209 ◽  
Author(s):  
Bor-Shuen Wang ◽  
Liang Feng ◽  
Mingna Liu ◽  
Xiaorong Liu ◽  
Jianhua Cang
Keyword(s):  
Critical Period ◽  
Environmental Enrichment ◽  
Orientation Preference ◽  
Binocular Matching

Three-dimensional image analysis and visualization in confocal light microscopy

1993 ◽  
Vol 51 ◽  
pp. 158-159
Author(s):  
J. K. Samarabandu ◽  
R. Acharya ◽  
D. R. Pareddy ◽  
P. C. Cheng
Keyword(s):  
Depth Perception ◽  
Computer Graphic ◽  
Three Dimensional ◽  
Cellular Organization ◽  
Data Set ◽  
Computational Burden ◽  
Interactive Operation ◽  
Cell Organization ◽  
Confocal Images ◽  
3D Digitization

In the study of cell organization in a maize meristem, direct viewing of confocal optical sections in 3D (by means of 3D projection of the volumetric data set, Figure 1) becomes very difficult and confusing because of the large number of nucleus involved. Numerical description of the cellular organization (e.g. position, size and orientation of each structure) and computer graphic presentation are some of the solutions to effectively study the structure of such a complex system. An attempt at data-reduction by means of manually contouring cell nucleus in 3D was reported (Summers et al., 1990). Apart from being labour intensive, this 3D digitization technique suffers from the inaccuracies of manual 3D tracing related to the depth perception of the operator. However, it does demonstrate that reducing stack of confocal images to a 3D graphic representation helps to visualize and analyze complex tissues (Figure 2). This procedure also significantly reduce computational burden in an interactive operation.

Lightness and depth perception: An update

2001 ◽  
Author(s):  
Alan L. Gilchrist ◽  
Dejan Todorovic
Keyword(s):  
Depth Perception
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