scholarly journals TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin

2011 ◽  
Vol 2 (1) ◽  
Author(s):  
Takashi Miyamoto ◽  
Matt J. Petrus ◽  
Adrienne E. Dubin ◽  
Ardem Patapoutian
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Nitric Oxide Synthesis ◽  
Oxide Synthase

scholarly journals Nitric oxide synthases in pregnant rat uterus

Reproduction ◽  
2001 ◽  
pp. 403-407 ◽  
Author(s):  
M Farina ◽  
ML Ribeiro ◽  
A Franchi
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Nitric Oxide Synthesis ◽  
Uterine Contractility ◽  
Pregnant Rat ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Nitric Oxide Synthase Activity ◽  
Inducible Nitric Oxide

The conversion of [14C]arginine into [14C]citrulline as an indicator of nitric oxide synthesis was studied in uteri isolated from rats on different days of gestation, after labour and during dioestrus. Nitric oxide synthesis was present in uterine tissues isolated at each stage of gestation and also in tissues collected during dioestrus and after labour. Expression of neuronal nitric oxide synthase was not detectable at any of the stages studied. Endothelial nitric oxide synthase was present at all the stages studied, but there was a significant increase on day 13 of gestation and a decrease thereafter, with the lowest expression recorded on the day after labour. Inducible nitric oxide synthase expression in rat uteri increased substantially during pregnancy, with the highest expression on day 13 of gestation; expression decreased at term and after labour. The changes in expression of inducible nitric oxide synthase were coincident with the changes in nitric oxide synthase activity in uteri treated with aminoguanidine. Thus, these findings indicate that an increase in expression of inducible nitric oxide synthase in the uterus may be important for maintenance of uterine quiescence during pregnancy and its decrease near the time of labour could have an effect on the start of uterine contractility.

Increased Nitric Oxide Synthesis and Inducible Nitric Oxide Synthase Expression in Patients with Alcoholic and Non-Alcoholic Liver Cirrhosis

1998 ◽  
Vol 94 (6) ◽  
pp. 637-643 ◽  
Author(s):  
A. Sánchez-Rodríguez ◽  
M. Criado ◽  
A. M. Rodríguez-López ◽  
A. Esteller ◽  
A. Martín De Arriba ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Liver Disease ◽  
Nitric Oxide Synthase ◽  
Mononuclear Cells ◽  
Control Group ◽  
Nitric Oxide Synthesis ◽  
Haemodynamic Parameters ◽  
Cirrhotic Patients ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

1. The synthesis and release of nitric oxide may play a role in the pathogenesis of peripheral vasodilatation and hyperdynamic circulation observed in liver cirrhosis. In this work, we analysed the synthesis of nitric oxide by the lympho-mononuclear cells of peripheral blood from patients with chronic alcoholic and non-alcoholic liver disease and we identified the isoform of nitric oxide synthase involved in the increased nitric oxide synthesis. 2. Patients were classified following clinical and histological criteria in non-alcoholic cirrhotic, alcoholic cirrhotic and non-cirrhotic chronic liver disease. We studied clinical and analytical characteristics, haemodynamic parameters and endotoxin levels in these patients. 3. Cirrhotic patients showed an increase of cardiac output and a decrease of peripheral vascular resistance. These patients had higher levels of plasma endotoxin than those observed in the control group. Nω-Nitro-l-arginine methyl ester (l-NAME)-inhibitable nitrite production from mononuclear lymphocyte cells was higher in patients than in the control group, the highest levels being in non-alcoholic cirrhotic patients, and the lowest levels in patients with non-cirrhotic alcoholic liver disease. 4. Immunocytochemistry studies revealed a positive immunoreactivity for the inducible isoform of nitric oxide synthase in lympho-mononuclear cells that was more evident in non-alcoholic than in alcoholic cirrhotic patients. By Northern blot, inducible nitric oxide synthase mRNA expression was observed only in lympho-mononuclear cells from non-alcoholic cirrhotic patients. 5. Our patients show a correlation between nitric oxide synthesis, endotoxin levels and haemodynamic parameters. 6. These findings indicate that lympho-mononuclear cell stimulation may play a role in elevated nitric oxide production in hepatic cirrhosis. Thus, this increased nitric oxide synthesis could be implicated in the pathogenesis of the haemodynamic disturbances frequently found in cirrhotic patients. This increase seems to be induced, at least in part, by activation of an inducible isoform of nitric oxide synthase.

scholarly journals Palmitoylation of Inducible Nitric-oxide Synthase at Cys-3 Is Required for Proper Intracellular Traffic and Nitric Oxide Synthesis

2004 ◽  
Vol 279 (53) ◽  
pp. 55682-55689 ◽  
Author(s):  
Inmaculada Navarro-Lérida ◽  
Maria Martha Corvi ◽  
Alberto Álvarez Barrientos ◽  
Francisco Gavilanes ◽  
Luc Gérard Berthiaume ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Nitric Oxide Synthesis ◽  
Intracellular Traffic ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide
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