scholarly journals The genetic regulatory signature of type 2 diabetes in human skeletal muscle

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Laura J. Scott ◽  
Michael R. Erdos ◽  
Jeroen R. Huyghe ◽  
Ryan P. Welch ◽  
Andrew T. Beck ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Human Skeletal Muscle

scholarly journals Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

Diabetes ◽  
2002 ◽  
Vol 51 (10) ◽  
pp. 2944-2950 ◽  
Author(s):  
D. E. Kelley ◽  
J. He ◽  
E. V. Menshikova ◽  
V. B. Ritov
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Human Skeletal Muscle

scholarly journals Proteome Analysis Reveals Phosphorylation of ATP Synthase β-Subunit in Human Skeletal Muscle and Proteins with Potential Roles in Type 2 Diabetes

2003 ◽  
Vol 278 (12) ◽  
pp. 10436-10442 ◽  
Author(s):  
Kurt Højlund ◽  
Krzysztof Wrzesinski ◽  
Peter Mose Larsen ◽  
Stephen J. Fey ◽  
Peter Roepstorff ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Atp Synthase ◽  
Human Skeletal Muscle ◽  
Proteome Analysis ◽  
Β Subunit

294-LB: Transcriptome-Wide Signals Converge Upon Mitochondrial Function in Developmental Stages of Type 2 Diabetes in Human Skeletal Muscle

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 294-LB
Author(s):  
LUKASZ SZCZERBINSKI ◽  
MAGDALENA NIEMIRA ◽  
KAROL SZCZERBINSKI ◽  
URSZULA PUCHTA ◽  
ELWIRA SIEWIEC ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Mitochondrial Function ◽  
Human Skeletal Muscle ◽  
Developmental Stages

Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity

2011 ◽  
Vol 27 (3) ◽  
pp. 286-297 ◽  
Author(s):  
Fredirick L. Mashili ◽  
Reginald L. Austin ◽  
Atul S. Deshmukh ◽  
Tomas Fritz ◽  
Kenneth Caidahl ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Glucose Uptake ◽  
Human Skeletal Muscle ◽  
Direct Effects ◽  
Diabetes And Obesity

scholarly journals Circulating Exosomal miR-20b-5p is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle

Diabetes ◽  
2018 ◽  
pp. db180470 ◽  
Author(s):  
Mutsumi Katayama ◽  
Oscar P.B Wiklander ◽  
Tomas Fritz ◽  
Kenneth Caidahl ◽  
Samir El- Andaloussi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Insulin Action ◽  
Human Skeletal Muscle

scholarly journals Thermotherapy Effects on Healthy and Type 2 Diabetes Human Skeletal Muscle Myoblast Cell Lines

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Janette A. Lindstrom ◽  
Felix Omoruyi ◽  
Jean Sparks
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Cell Lines ◽  
Acute Treatment ◽  
Human Skeletal Muscle ◽  
Chronic Treatment ◽  
Muscle Cells ◽  
Skeletal Muscle Cells

Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels with associated disordered carbohydrate and lipid metabolism. Type 2 diabetes (T2D) specifically has been shown to cause a decrease in skeletal muscle mass due to oxidative stress. This study investigated a treatment option for T2D through thermotherapy on healthy (HSMM) and T2D (D-HSMM) human skeletal muscle cells. The goals were to determine the effects of thermotherapy, long-term (chronic) and short-term (acute), on HSMM and D-HSMM cell viabilities and oxidative stress. HSMM and D-HSMM cells were grown to confluency, harvested, and counted to determine density. Acute and chronic heat treatments were applied to both cell lines. The chronic treatment consisted of a 30-minute exposure to 40°C, three times a week for three weeks; the acute treatment was a one-time exposure. Oxidative stress assays and cell viabilities were tested 24 hours after heat treatments. Results indicated no significant effect on the cell viability of HSMM and D-HSMM cells. The acute treatment had a significant increase ( p ≤ 0.05 ) of MDA concentration compared to the chronic treatment. The chronic treatment had a significant increase ( p ≤ 0.05 ) in catalase activity compared to the acute treatment. The SOD activity had no significant change ( p > 0.05 ) between the chronic and acute treatments. In conclusion, acute thermotherapy may not be beneficial for skeletal muscle cells due to the observed increase in oxidative stress, especially in the D-HSMM cells.

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