scholarly journals Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Mariena J. A. van der Plas ◽  
Ravi K. V. Bhongir ◽  
Sven Kjellström ◽  
Helena Siller ◽  
Gopinath Kasetty ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Inflammatory Responses ◽  
Human Thrombin ◽  
Pseudomonas Aeruginosa Elastase

scholarly journals Nutritional Effects on Host Response to Lung Infections with Mucoid Pseudomonas aeruginosa in Mice

2004 ◽  
Vol 72 (3) ◽  
pp. 1479-1486 ◽  
Author(s):  
Anna M. van Heeckeren ◽  
Mark Schluchter ◽  
Lintong Xue ◽  
Juan Alvarez ◽  
Steven Freedman ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Docosahexaenoic Acid ◽  
Knockout Mice ◽  
Host Response ◽  
Inflammatory Responses ◽  
Liquid Diet ◽  
Wild Type ◽  
Agarose Beads ◽  
Lung Infections

ABSTRACT In cystic fibrosis, a recessive genetic disease caused by defects in the cystic fibrosis conductance regulator (CFTR), the main cause of death is lung infection and inflammation. Nutritional deficits have been proposed to contribute to the excessive host inflammatory response in both humans and Cftr-knockout mice. Cftr-knockout mice and gut-corrected Cftr-knockout mice expressing human CFTR primarily in the gut were challenged with Pseudomonas aeruginosa-laden agarose beads; they responded similarly with respect to bronchoalveolar lavage cell counts and levels of the acute-phase cytokines tumor necrosis factor alpha, interleukin-1β (IL-1β), and IL-6. Wild-type mice fed the liquid diet used to prevent intestinal obstruction in Cftr-knockout mice had inflammatory responses to P. aeruginosa-laden agarose beads similar to those of wild-type mice fed an enriched solid diet, so dietary effects are unlikely to account for differences between wild-type mice and mice with cystic fibrosis. Finally, since cystic fibrosis patients and Cftr-knockout mice have an imbalance in fatty acids (significantly lower-than-normal levels of docosahexaenoic acid), the effects of specific supplementation with docosahexaenoic acid of wild-type and Cftr-knockout mice on their inflammatory responses to P. aeruginosa-laden agarose beads were tested. There were no significant differences (P = 0.35) in cumulative survival rates between Cftr-knockout mice and wild-type mice provided with either the liquid diet Peptamen or Peptamen containing docosahexaenoic acid. In conclusion, diet and docosahexaenoic acid imbalances alone are unlikely to explain the differences in the host response to lung infections with mucoid P. aeruginosa between mice with cystic fibrosis and their wild-type counterparts.

scholarly journals Pseudomonas aeruginosa Elastase

1965 ◽  
Vol 240 (8) ◽  
pp. 3295-3304
Author(s):  
Kazuyuki Morihara ◽  
Hiroshige Tsuzuki ◽  
Tatsushi Oka ◽  
Hideo Inoue ◽  
Mitsuo Ebata
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Pseudomonas Aeruginosa Elastase

scholarly journals Degradation of basement membranes by Pseudomonas aeruginosa elastase.

1989 ◽  
Vol 57 (12) ◽  
pp. 3783-3787 ◽  
Author(s):  
P A Bejarano ◽  
J P Langeveld ◽  
B G Hudson ◽  
M E Noelken
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Basement Membranes ◽  
Pseudomonas Aeruginosa Elastase

Activation of human plasma prekallikrein by Pseudomonas aeruginosa elastase in vitro

1991 ◽  
Vol 1097 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Yoko Shibuya ◽  
Hideaki Tanaka ◽  
Norikazu Nishino ◽  
Hiroaki Okabe ◽  
Takeshi Kambara ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Human Plasma ◽  
Pseudomonas Aeruginosa Elastase
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