scholarly journals Correction: Corrigendum: DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Aliza P. Wingo ◽  
Lynn M. Almli ◽  
Jennifer S. Stevens ◽  
Torsten Klengel ◽  
Monica Uddin ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Comorbid Depression ◽  
Microrna Regulation ◽  
Post Traumatic

scholarly journals DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Aliza P. Wingo ◽  
Lynn M. Almli ◽  
Jennifer S. Stevens ◽  
Torsten Klengel ◽  
Monica Uddin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Molecular Mechanisms ◽  
Stress Disorder ◽  
Mirna Regulation ◽  
Post Traumatic Stress ◽  
Comorbid Depression ◽  
Genome Wide ◽  
Post Traumatic

Abstract DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post-transcriptionally in brain and other tissues and is involved in synaptic maturation and plasticity. Here, through genome-wide differential gene expression survey of post-traumatic stress disorder (PTSD) with comorbid depression (PTSD&Dep), we find that blood DICER1 expression is significantly reduced in cases versus controls, and replicate this in two independent cohorts. Our follow-up studies find that lower blood DICER1 expression is significantly associated with increased amygdala activation to fearful stimuli, a neural correlate for PTSD. Additionally, a genetic variant in the 3′ un-translated region of DICER1, rs10144436, is significantly associated with DICER1 expression and with PTSD&Dep, and the latter is replicated in an independent cohort. Furthermore, genome-wide differential expression survey of miRNAs in blood in PTSD&Dep reveals miRNAs to be significantly downregulated in cases versus controls. Together, our novel data suggest DICER1 plays a role in molecular mechanisms of PTSD&Dep through the DICER1 and the miRNA regulation pathway.

Sign in / Sign up

Export Citation Format

Share Document