scholarly journals Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Caroline P. Le ◽  
Cameron J. Nowell ◽  
Corina Kim-Fuchs ◽  
Edoardo Botteri ◽  
Jonathan G. Hiller ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Tumour Cell ◽  
Cell Dissemination ◽  
Tumour Cell Dissemination

Authors' reply: Tumour cell dissemination following endoscopic stent insertion (Br J Surg 2007; 94: 1151-1154)

2007 ◽  
Vol 95 (1) ◽  
pp. 128-128
Author(s):  
K. Maruthachalam ◽  
G. E. Lash ◽  
B. K. Shenton ◽  
A. F. Horgan
Keyword(s):  
Tumour Cell ◽  
Stent Insertion ◽  
Endoscopic Stent ◽  
Cell Dissemination ◽  
Tumour Cell Dissemination

Early tumour cell dissemination in non-small cell lung cancer

1994 ◽  
Vol 30 ◽  
pp. S35
Author(s):  
K. Pantel ◽  
B. Passlick ◽  
J.R. Izbicki ◽  
M. Angstwurm ◽  
B. Kubuschok ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumour Cell ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Dissemination ◽  
Tumour Cell Dissemination

Spontaneous changes in tumour cell dissemination to bone marrow in colorectal cancer

2009 ◽  
Vol 12 (8) ◽  
pp. 776-782 ◽  
Author(s):  
V. Buxhofer-Ausch ◽  
C. Ausch ◽  
E. Kitzweger ◽  
M. Mollik ◽  
A. Reiner-Concin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Bone Marrow ◽  
Tumour Cell ◽  
Cell Dissemination ◽  
Tumour Cell Dissemination

scholarly journals Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis?

Oncogenesis ◽  
2021 ◽  
Vol 10 (3) ◽  
Author(s):  
Sini Karinen ◽  
Krista Juurikka ◽  
Roosa Hujanen ◽  
Wafa Wahbi ◽  
Elin Hadler-Olsen ◽  
...  
Keyword(s):  
Tumour Cell ◽  
Lymphatic Metastasis ◽  
Tumour Cells ◽  
Metastatic Tumour ◽  
Tumour Metastasis ◽  
And Function ◽  
Cell Dissemination ◽  
Tumour Cell Dissemination

AbstractLymphatic metastasis represents the main route of tumour cell dissemination in oral squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting cancer-related lymphangiogenesis to date. The lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1), a specific lymphatic marker, is associated with poor survival in OSCC patients. In this study, we present a potential novel mechanism of lymphatic metastasis in OSCC—lymphatic mimicry (LM), a process whereby tumour cells form cytokeratin+/LYVE-1+, but podoplanin-negative, mosaic endothelial-like vessels. LM was detected in one-third (20/57; 35.08%) of randomly selected OSCC patients. The LM-positive patients had shorter overall survival (OS) compared to LM-negative group albeit not statistically significant. Highly-metastatic tumour cells formed distinct LM structures in vitro and in vivo. Importantly, the siRNA-mediated knockdown of LYVE-1 not only impaired tumour cell migration but also blunted their capacity to form LM-vessels in vitro and reduced tumour metastasis in vivo. Together, our findings uncovered, to our knowledge, a previously unknown expression and function of LYVE-1 in OSCC, whereby tumour cells could induce LM formation and promote lymphatic metastasis. Finally, more detailed studies on LM are warranted to better define this phenomenon in the future. These studies could benefit the development of targeted therapeutics for blocking tumour-related lymphangiogenesis.

scholarly journals Increased nm23 immunoreactivity is associated with selective inhibition of systemic tumour cell dissemination

2002 ◽  
Vol 55 (3) ◽  
pp. 184-189 ◽  
Author(s):  
A N J Graham ◽  
P Maxwell ◽  
K Mulholland ◽  
A H Patterson ◽  
N Anderson ◽  
...  
Keyword(s):  
Tumour Cell ◽  
Selective Inhibition ◽  
Cell Dissemination ◽  
Tumour Cell Dissemination
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