scholarly journals PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Xin Wang ◽  
Youn-Sang Jung ◽  
Sohee Jun ◽  
Sunhye Lee ◽  
Wenqi Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Wnt Signaling ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Plasticity

scholarly journals PRMT1 regulates EGFR and Wnt signaling pathways and is a promising target for combinatorial treatment of breast cancer

2021 ◽  
Author(s):  
Samyuktha Suresh ◽  
Solène Huard ◽  
Amélie Brisson ◽  
Fariba Némati ◽  
Coralie Poulard ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Wnt Signaling ◽  
Signaling Pathways ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Xenograft Model ◽  
Growth Factor Receptor ◽  
Breast Cancer Cell Lines ◽  
Type I ◽  
Cancer Subtypes

Identifying new therapeutic strategies for triple-negative breast cancer (TNBC) patients is a priority as these patients are highly prone to relapse after chemotherapy. Here, we found that protein arginine methyltransferase 1 (PRMT1) is highly expressed in all breast cancer subtypes. Its depletion decreases cell survival by inducing DNA damage and apoptosis in various breast cancer cell lines. Transcriptomic analysis and chromatin immunoprecipitation revealed that PRMT1 regulates the epidermal growth factor receptor (EGFR) and the Wnt signaling pathways, reported to be activated in TNBC. The enzymatic activity of PRMT1 is also required to stimulate the canonical Wnt pathway. Recently developed type I PRMT inhibitors decrease breast cancer cell proliferation and show anti-tumor activity in a TNBC xenograft model. These inhibitors display synergistic interactions with some chemotherapies used to treat TNBC patients, as well as the EGFR inhibitor, erlotinib. Therefore, targeting PRMT1 in combination with drugs used in the clinic may improve current treatments for TNBC patients.

242: Characterisation of retinoic acid effect on breast cancer cell plasticity

2014 ◽  
Vol 50 ◽  
pp. S56
Author(s):  
G. Paroni ◽  
A. Zanetti ◽  
R. Affatato ◽  
E. Garattini
Keyword(s):  
Breast Cancer ◽  
Retinoic Acid ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Plasticity ◽  
Acid Effect

Abstract 1514: The Warburg effect in stromal cells drives breast cancer cell plasticity via interleukin 6

2012 ◽  
Author(s):  
Pasquale Sansone ◽  
Claudio Ceccarelli ◽  
Gianluca Storci ◽  
Marjan Berishaj ◽  
Monica Cricca ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Stromal Cells ◽  
Interleukin 6 ◽  
Warburg Effect ◽  
Cell Plasticity ◽  
The Warburg Effect

The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b

2017 ◽  
Vol 10 (483) ◽  
pp. eaak9557 ◽  
Author(s):  
Wu Zhou ◽  
Xiao-lei Ye ◽  
Jun Xu ◽  
Ming-Guo Cao ◽  
Zheng-Yu Fang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Plasticity

scholarly journals CDYL2 Epigenetically Regulates MIR124 to Control NF-κB/STAT3-Dependent Breast Cancer Cell Plasticity

iScience ◽  
2020 ◽  
Vol 23 (6) ◽  
pp. 101141 ◽  
Author(s):  
Maha Siouda ◽  
Audrey D. Dujardin ◽  
Laetitia Barbollat-Boutrand ◽  
Marco A. Mendoza-Parra ◽  
Benjamin Gibert ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Plasticity
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