scholarly journals Divergent transcriptional activities determine limb identity

2010 ◽  
Vol 1 (1) ◽  
Author(s):  
Jean-François Ouimette ◽  
Marisol Lavertu Jolin ◽  
Aurore L'honoré ◽  
Anthony Gifuni ◽  
Jacques Drouin
Keyword(s):  
Limb Identity

scholarly journals Finger or toe: the molecular basis of limb identity

Development ◽  
2003 ◽  
Vol 130 (26) ◽  
pp. 6401-6410 ◽  
Author(s):  
M. Logan
Keyword(s):  
Molecular Basis ◽  
Limb Identity

scholarly journals Pigeon foot feathering reveals conserved limb identity networks

2019 ◽  
Author(s):  
Elena F. Boer ◽  
Hannah F. Van Hollebeke ◽  
Sungdae Park ◽  
Carlos R. Infante ◽  
Douglas B. Menke ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Limb Development ◽  
Limb Bud ◽  
Differentially Expressed ◽  
Evolutionarily Conserved ◽  
Genes Encoding ◽  
Embryonic Limb ◽  
Summary Statement ◽  
Limb Identity

AbstractThe tetrapod limb is a stunning example of evolutionary diversity, with dramatic variation not only among distantly related species, but also between the serially homologous forelimbs (FLs) and hindlimbs (HLs) within species. Despite this variation, highly conserved genetic and developmental programs underlie limb development and identity in all tetrapods, raising the question of how limb diversification is generated from a conserved toolkit. In some breeds of domestic pigeon, shifts in the expression of two conserved limb identity transcription factors,PITX1andTBX5, are associated with the formation of feathered HLs with partial FL identity. To determine how modulation ofPITX1andTBX5expression affects downstream gene expression, we compared the transcriptomes of embryonic limb buds from pigeons with scaled and feathered HLs. We identified a set of differentially expressed genes enriched for genes encoding transcription factors, extracellular matrix proteins, and components of developmental signaling pathways with important roles in limb development. A subset of the genes that distinguish scaled and feathered HLs are also differentially expressed between FL and scaled HL buds in pigeons, pinpointing a set of gene expression changes downstream ofPITX1andTBX5in the partial transformation from HL to FL identity. We extended our analyses by comparing pigeon limb bud transcriptomes to chicken, anole lizard, and mammalian datasets to identify deeply conservedPITX1- andTBX5-regulated components of the limb identity program. Our analyses reveal a suite of predominantly low-level gene expression changes that are conserved across amniotes to regulate the identity of morphologically distinct limbs.Summary statementIn feather-footed pigeons, mutant alleles ofPITX1andTBX5drive the partial redeployment of an evolutionarily conserved forelimb genetic program in the hindlimb.

scholarly journals Pigeon foot feathering reveals conserved limb identity networks

2019 ◽  
Vol 454 (2) ◽  
pp. 128-144 ◽  
Author(s):  
Elena F. Boer ◽  
Hannah F. Van Hollebeke ◽  
Sungdae Park ◽  
Carlos R. Infante ◽  
Douglas B. Menke ◽  
...  
Keyword(s):  
Limb Identity

scholarly journals Author response: Molecular shifts in limb identity underlie development of feathered feet in two domestic avian species

2016 ◽  
Author(s):  
Eric T Domyan ◽  
Zev Kronenberg ◽  
Carlos R Infante ◽  
Anna I Vickrey ◽  
Sydney A Stringham ◽  
...  
Keyword(s):  
Avian Species ◽  
Author Response ◽  
Limb Identity

scholarly journals Selector Genes and Limb Identity in Arthropods and Vertebrates

Cell ◽  
1999 ◽  
Vol 97 (3) ◽  
pp. 283-286 ◽  
Author(s):  
Scott D Weatherbee ◽  
Sean B Carroll
Keyword(s):  
Selector Genes ◽  
Limb Identity

Tbx genes and limb identity in chick embryo development

Development ◽  
1998 ◽  
Vol 125 (10) ◽  
pp. 1867-1875 ◽  
Author(s):  
A. Isaac ◽  
C. Rodriguez-Esteban ◽  
A. Ryan ◽  
M. Altabef ◽  
T. Tsukui ◽  
...  
Keyword(s):  
Chick Embryo ◽  
Embryo Development ◽  
Limb Identity

Tbx-2, Tbx-3, Tbx-4 and Tbx-5 chick genes have been isolated and, like the mouse homologues, are expressed in the limb regions. Tbx-2 and Tbx-3 are expressed in anterior and posterior domains in wings and legs, as well as throughout the flank. Of particular interest, however, are Tbx-5, which is expressed in wing and flank but not leg, and Tbx-4, which is expressed very strongly in leg but not wing. Grafts of leg tissue to wing and wing tissue to leg give rise to toe-like or wing-like digits in wing and leg respectively. Expression of Tbx-4 is stable when leg tissue is grafted to wing, and Tbx-5 expression is stable when wing tissue is grafted to leg. Induction of either extra wings or legs from the flank by applying FGF-2 in different positions alters the expression of Tbx-4 and Tbx-5 in such a way that suggests that the amount of Tbx-4 that is expressed in the limb determines the type that will form. The ectopic limb always displays a limb-like Tbx-3 expression. Thus Tbx-4 and Tbx-5 are strong candidates for encoding ‘wingness’ and ‘legness’.

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