scholarly journals Ciliated neurons lining the central canal sense both fluid movement and pH through ASIC3

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Elham Jalalvand ◽  
Brita Robertson ◽  
Peter Wallén ◽  
Sten Grillner
Keyword(s):  
Central Canal ◽  
Fluid Movement ◽  
Ciliated Neurons

scholarly journals Effect of the Central Canal in the Spinal Cord on Fluid Movement within the Cord

2013 ◽  
Vol 26 (5) ◽  
pp. 585-590 ◽  
Author(s):  
Ida N. Drøsdal ◽  
Kent-Andre Mardal ◽  
Karen Støverud ◽  
Victor Haughton
Keyword(s):  
Spinal Cord ◽  
Central Canal ◽  
Fluid Movement

scholarly journals Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection

Cell Reports ◽  
2021 ◽  
Vol 34 (4) ◽  
pp. 108671
Author(s):  
Sophie Skarlatou ◽  
Coralie Hérent ◽  
Elisa Toscano ◽  
César S. Mendes ◽  
Julien Bouvier ◽  
...  
Keyword(s):  
Central Canal

scholarly journals Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal

PLoS Biology ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. e3000470 ◽  
Author(s):  
Christine M. Tait ◽  
Kavitha Chinnaiya ◽  
Elizabeth Manning ◽  
Mariyam Murtaza ◽  
John-Paul Ashton ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Central Canal

scholarly journals The Effect of Fluid Flow Shear Stress and Substrate Stiffness on Yes-Associated Protein (YAP) Activity and Osteogenesis in Murine Osteosarcoma Cells

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3128
Author(s):  
Thomas R. Coughlin ◽  
Ali Sana ◽  
Kevin Voss ◽  
Abhilash Gadi ◽  
Upal Basu-Roy ◽  
...  
Keyword(s):  
Shear Stress ◽  
Fluid Flow ◽  
Bone Cells ◽  
Bone Cancer ◽  
Substrate Stiffness ◽  
Flow Shear ◽  
Fluid Movement ◽  
Flow Shear Stress ◽  
Fluid Flow Shear Stress ◽  
New Treatments

Osteosarcoma (OS) is an aggressive bone cancer originating in the mesenchymal lineage. Prognosis for metastatic disease is poor, with a mortality rate of approximately 40%; OS is an aggressive disease for which new treatments are needed. All bone cells are sensitive to their mechanical/physical surroundings and changes in these surroundings can affect their behavior. However, it is not well understood how OS cells specifically respond to fluid movement, or substrate stiffness—two stimuli of relevance in the tumor microenvironment. We used cells from spontaneous OS tumors in a mouse engineered to have a bone-specific knockout of pRb-1 and p53 in the osteoblast lineage. We silenced Sox2 (which regulates YAP) and tested the effect of fluid flow shear stress (FFSS) and substrate stiffness on YAP expression/activity—which was significantly reduced by loss of Sox2, but that effect was reversed by FFSS but not by substrate stiffness. Osteogenic gene expression was also reduced in the absence of Sox2 but again this was reversed by FFSS and remained largely unaffected by substrate stiffness. Thus we described the effect of two distinct stimuli on the mechanosensory and osteogenic profiles of OS cells. Taken together, these data suggest that modulation of fluid movement through, or stiffness levels within, OS tumors could represent a novel consideration in the development of new treatments to prevent their progression.

scholarly journals Fluid Movement in Occluded Single Capillaries of Rabbit Omentum

1971 ◽  
Vol 28 (3) ◽  
pp. 358-366 ◽  
Author(s):  
J. S. LEE ◽  
L. H. SMAJE ◽  
B. W. ZWEIFACH
Keyword(s):  
Fluid Movement

scholarly journals Standard and cardiac-gated phase-contrast magnetic resonance imaging in the clinical course of patients with Chiari malformation Type I

2011 ◽  
Vol 31 (3) ◽  
pp. E5 ◽  
Author(s):  
Uwe Max Mauer ◽  
Andreas Gottschalk ◽  
Carolin Mueller ◽  
Linda Weselek ◽  
Ulrich Kunz ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Chiari Malformation ◽  
Phase Contrast ◽  
Foramen Magnum ◽  
Central Canal ◽  
Type I ◽  
Csf Flow ◽  
Chiari Malformation Type I ◽  
Cerebrospinal Fluid Flow ◽  
Contrast Magnetic Resonance

Object The causal treatment of Chiari malformation Type I (CM-I) consists of removing the obstruction of CSF flow at the level of the foramen magnum. Cerebrospinal fluid flow can be visualized using dynamic phase-contrast MR imaging. Because there is only a paucity of studies evaluating CSF dynamics in the region of the spinal canal on the basis of preoperative and postoperative measurements, the authors investigated the clinical usefulness of cardiacgated phase-contrast MR imaging in patients with CM-I. Methods Ninety patients with CM-I underwent preoperative MR imaging of CSF pulsation. Syringomyelia was present in 59 patients and absent in 31 patients. Phase-contrast MR imaging of the entire CNS was used to investigate 22 patients with CM-I before surgery and after a mean postoperative period of 12 months (median 12 months, range 3–33 months). In addition to the dynamic studies, absolute flow velocities, the extension of the syrinx, and tonsillar descent were also measured. Results The changes in pulsation were highly significant in the region of the (enlarged) cistern (p = 0.0005). Maximum and minimum velocities (the pulsation amplitude) increased considerably in the region where the syrinx was largest in diameter. The changes of pulsation in these patients were significant in the subarachnoid space in all spinal segments but not in the syrinx itself and in the central canal. Conclusions The demonstration of CSF flow pulsation can contribute to assessments of surgical outcomes. The results presented here, however, raise doubts about current theories on the pathogenesis of syringomyelia.

Anatomical and physiological studies of the gray matter surrounding the spinal cord central canal

1983 ◽  
Vol 220 (3) ◽  
pp. 321-335 ◽  
Author(s):  
Richard L. Nahin ◽  
Anne M. Madsen ◽  
Glenn J. Giesler
Keyword(s):  
Spinal Cord ◽  
Gray Matter ◽  
Central Canal ◽  
Physiological Studies
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