The critical role of extreme heat for maize production in the United States

2013 ◽  
Vol 3 (5) ◽  
pp. 497-501 ◽  
Author(s):  
David B. Lobell ◽  
Graeme L. Hammer ◽  
Greg McLean ◽  
Carlos Messina ◽  
Michael J. Roberts ◽  
...  
Keyword(s):  
United States ◽  
Critical Role ◽  
The United States ◽  
Extreme Heat ◽  
Maize Production

scholarly journals May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells

2018 ◽  
Vol 39 (2) ◽  
pp. 367-370 ◽  
Author(s):  
Cesar V Borlongan ◽  
Hung Nguyen ◽  
Trenton Lippert ◽  
Eleonora Russo ◽  
Julian Tuazon ◽  
...  
Keyword(s):  
United States ◽  
Stem Cells ◽  
Therapeutic Option ◽  
Critical Role ◽  
The United States ◽  
Brain Disorders ◽  
Mitochondrial Dysfunctions ◽  
Limited Therapeutic Option ◽  
The World

Stroke is a major cause of death and disability in the United States and around the world with limited therapeutic option. Here, we discuss the critical role of mitochondria in stem cell-mediated rescue of stroke brain by highlighting the concept that deleting the mitochondria from stem cells abolishes the cells’ regenerative potency. The application of innovative approaches entailing generation of mitochondria-voided stem cells as well as pharmacological inhibition of mitochondrial function may elucidate the mechanism underlying transfer of healthy mitochondria to ischemic cells, thereby providing key insights in the pathology and treatment of stroke and other brain disorders plagued with mitochondrial dysfunctions.

Introduction to the Special Issue: Understanding the Direct Support Workforce in the United States

2020 ◽  
Vol 58 (3) ◽  
pp. 189-191
Author(s):  
Carol B. Laws ◽  
Amy S. Hewitt
Keyword(s):  
United States ◽  
Critical Role ◽  
The United States ◽  
Special Issue ◽  
Full Inclusion ◽  
Direct Support ◽  
Direct Support Professionals ◽  
Increasing Demand

Abstract This special issue on the direct support workforce highlights the critical role of the direct support workforce in the quality of life of people with intellectual and developmental disabilities (IDD) in the United States. Although there is increasing demand for this workforce, challenges in the recruitment, training, and retention of direct support professionals (DSPs) threatens the safety, health, and full inclusion of people with IDD living in the community. This special issue brings to the forefront current research to understand this workforce and their importance and to consider strategies to address the complex challenges facing DSPs so that people with disabilities can live and thrive in their communities.

scholarly journals Conflicts in contemporary Asia – theoretical approach

2018 ◽  
Vol 188 (2) ◽  
pp. 105-120
Author(s):  
Szymon Niedziela
Keyword(s):  
United States ◽  
Theoretical Approach ◽  
Critical Role ◽  
The United States ◽  
Political Activity ◽  
Security Architecture ◽  
Direct Impact ◽  
Internal Conflicts ◽  
Free Development

The article attempts to theoretically systematize conflicts in contemporary Asia. At the beginning, attention was paid to the cultural and civilizational determinants of disputes and tensions in the region, which have a direct impact on the sphere of political activity of individual states. It has been found that ethnic and religious heterogeneity is the cause of tensions in Asia in most cases. The critical role of the United States in creating new security architecture across the Asian region has been determined. At the same time, it has been emphasized that multifaceted diversity is not always at odds with conflict-free development and stability. The exemplification of this hypothesis is Malaysia – a country of three cultures (Islamic, Chinese and Hindu). This country gives an example for the whole Asia that diversity does not mean the fatalism of internal conflicts. Malaysia can be an inspiration, especially for the Islamic civilizational circle.

scholarly journals On the Role of SST Forcing in the 2011 and 2012 Extreme U.S. Heat and Drought: A Study in Contrasts

2014 ◽  
Vol 15 (3) ◽  
pp. 1255-1273 ◽  
Author(s):  
Hailan Wang ◽  
Siegfried Schubert ◽  
Randal Koster ◽  
Yoo-Geun Ham ◽  
Max Suarez
Keyword(s):  
United States ◽  
General Circulation ◽  
Rapid Development ◽  
The United States ◽  
Tropical Pacific ◽  
Extreme Heat ◽  
The Pacific ◽  
Sst Forcing ◽  
The Tropical Pacific

Abstract This study compares the extreme heat and drought that developed over the United States in 2011 and 2012 with a focus on the role of sea surface temperature (SST) forcing. Experiments with the NASA Goddard Earth Observing System, version 5 (GEOS-5), atmospheric general circulation model show that the winter/spring response over the United States to the Pacific SST is remarkably similar for the two years despite substantial differences in the tropical Pacific SST. As such, the pronounced winter and early spring temperature differences between the two years (warmth confined to the south in 2011 and covering much of the continent in 2012) primarily reflect differences in the contributions from the Atlantic and Indian Oceans, with both acting to cool the east and upper Midwest during 2011, while during 2012 the Indian Ocean reinforced the Pacific-driven, continental-wide warming and the Atlantic played a less important role. During late spring and summer of 2011, the tropical Pacific SST forced a continued warming and drying over the southern United States, though considerably weaker than observed. Nevertheless, the observed 2011 anomalies fall well within the model’s intraensemble spread. In contrast, the observed rapid development of intense heat and drying over the central United States during June and July 2012 falls on the margins of the model’s intraensemble spread, with the response to the SST giving little indication that 2012 would produce record-breaking precipitation deficits and heat. A diagnosis of the 2012 observed circulation anomalies shows that the most extreme heat and drought was tied to the development of a stationary Rossby wave and an associated anomalous upper-tropospheric high maintained by weather transients.

scholarly journals COVID-19: Sleep, Circadian Rhythms and Immunity – Repurposing Drugs and Chronotherapeutics for SARS-CoV-2

2021 ◽  
Vol 15 ◽  
Author(s):  
Allan Giri ◽  
Ashokkumar Srinivasan ◽  
Isaac Kirubakaran Sundar
Keyword(s):  
United States ◽  
Circadian Rhythms ◽  
Respiratory Infections ◽  
Critical Role ◽  
The Elderly ◽  
The United States ◽  
Age Related ◽  
Target Organs ◽  
Novel Coronavirus

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has affected nearly 28 million people in the United States and has caused more than five hundred thousand deaths as of February 21, 2021. As the novel coronavirus continues to take its toll in the United States and all across the globe, particularly among the elderly (>65 years), clinicians and translational researchers are taking a closer look at the nexus of sleep, circadian rhythms and immunity that may contribute toward a more severe coronavirus disease-19 (COVID-19). SARS-CoV-2-induced multi-organ failure affects both central and peripheral organs, causing increased mortality in the elderly. However, whether differences in sleep, circadian rhythms, and immunity between older and younger individuals contribute to the age-related differences in systemic dysregulation of target organs observed in SARS-CoV-2 infection remain largely unknown. Current literature demonstrates the emerging role of sleep, circadian rhythms, and immunity in the development of chronic pulmonary diseases and respiratory infections in human and mouse models. The exact mechanism underlying acute respiratory distress syndrome (ARDS) and other cardiopulmonary complications in elderly patients in combination with associated comorbidities remain unclear. Nevertheless, understanding the critical role of sleep, circadian clock dysfunction in target organs, and immune status of patients with SARS-CoV-2 may provide novel insights into possible therapies. Chronotherapy is an emerging concept that is gaining attention in sleep medicine. Accumulating evidence suggests that nearly half of all physiological functions follow a strict daily rhythm. However, healthcare professionals rarely take implementing timed-administration of drugs into consideration. In this review, we summarize recent findings directly relating to the contributing roles of sleep, circadian rhythms and immune response in modulating infectious disease processes, and integrate chronotherapy in the discussion of the potential drugs that can be repurposed to improve the treatment and management of COVID-19.

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