Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

Evguenia Strom; Swati Sathe; Pavel G Komarov; Olga B Chernova; Ivanda Pavlovska; Inna Shyshynova; Dmitry A Bosykh; Lyudmila G Burdelya; Roger M Macklis; Rami Skaliter; Elena A Komarova; Andrei V Gudkov

doi:10.1038/nchembio809

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

Nature Chemical Biology ◽

10.1038/nchembio809 ◽

2006 ◽

Vol 2 (9) ◽

pp. 474-479 ◽

Cited By ~ 238

Author(s):

Evguenia Strom ◽

Swati Sathe ◽

Pavel G Komarov ◽

Olga B Chernova ◽

Ivanda Pavlovska ◽

...

Keyword(s):

Gamma Radiation ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Binding To Mitochondria

Download Full-text

Faculty Opinions recommendation of Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1021658.247635 ◽

2004 ◽

Author(s):

William Kaelin

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Shh Pathway ◽

Molecule Inhibitor

Download Full-text

Faculty Opinions recommendation of Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1025625.322882 ◽

2005 ◽

Author(s):

James Stivers

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Atm Kinase ◽

Molecule Inhibitor ◽

Hiv 1

Download Full-text

Faculty Opinions recommendation of Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1033159.375732 ◽

2006 ◽

Author(s):

Berl R Oakley

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor

Download Full-text

Faculty Opinions recommendation of The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1066069.520680 ◽

2007 ◽

Author(s):

Nathanael Gray

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Bi 2536

Download Full-text

Faculty Opinions recommendation of The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1066069.519039 ◽

2007 ◽

Author(s):

Tarun Kapoor

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Bi 2536

Download Full-text

Faculty Opinions recommendation of Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1283961.751061 ◽

2009 ◽

Author(s):

Marie-France Carlier

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Actin Assembly ◽

Molecule Inhibitor ◽

Identification And Characterization

Download Full-text

Faculty Opinions recommendation of Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.5059957.4994055 ◽

2010 ◽

Author(s):

Michael Weber ◽

Daniel G Gioeli

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Amino Terminus ◽

Recurrent Prostate Cancer ◽

Molecule Inhibitor

Download Full-text

Faculty Opinions recommendation of A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717957380.793461863 ◽

2012 ◽

Author(s):

Pengbo Zhou ◽

Jeffrey Hannah

Keyword(s):

Multiple Myeloma ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Myeloma Cells ◽

Molecule Inhibitor ◽

Specific Protease ◽

Ubiquitin Specific Protease

Download Full-text

Faculty Opinions recommendation of Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717959626.793462957 ◽

2012 ◽

Author(s):

Mark Searcey

Keyword(s):

Small Molecule ◽

Tumor Regression ◽

Small Molecule Inhibitor ◽

Complete Tumor Regression ◽

Molecule Inhibitor ◽

Complete Tumor

Download Full-text

Faculty Opinions recommendation of A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726171812.793535824 ◽

2017 ◽

Author(s):

WH Wilson Tang

Keyword(s):

Hypertrophic Cardiomyopathy ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor

Download Full-text