scholarly journals An in vitro translation, selection and amplification system for peptide nucleic acids

2009 ◽  
Vol 6 (2) ◽  
pp. 148-155 ◽  
Author(s):  
Yevgeny Brudno ◽  
Michael E Birnbaum ◽  
Ralph E Kleiner ◽  
David R Liu
Keyword(s):  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
In Vitro Translation ◽  
Amplification System

Hydroxyproline-Based DNA Mimics: A Review on Synthesis and Properties

2006 ◽  
Vol 71 (7) ◽  
pp. 929-955 ◽  
Author(s):  
Vladimir A. Efimov ◽  
Oksana G. Chakhmakhcheva
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Phosphonic Acid ◽  
Peptide Nucleic Acids ◽  
Biological Properties ◽  
High Potential ◽  
Physicochemical And Biological Properties

With the aim to improve physicochemical and biological properties of natural oligonucleotides, many types of DNA analogues and mimics are designed on the basis of hydroxyproline and its derivatives, and their properties are evaluated. Among them, two types of DNA mimics representing hetero-oligomers constructed from alternating monomers of phosphono peptide nucleic acids and monomers on the base of trans-1-acetyl-4-hydroxy-L-proline (HypNA-pPNAs) and oligomers constructed from monomers containing (2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-phosphonic acid backbone (pHypNAs) are of particular interest. In a set of in vitro and in vivo assays, it was shown that HypNA-pPNAs and pHypNAs demonstrated a high potential for the use in nucleic acid based diagnostics, isolation of nucleic acids and antisense experiments. A review with 53 references.

scholarly journals Multifunctional Delivery Systems for Peptide Nucleic Acids

2020 ◽  
Vol 14 (1) ◽  
pp. 14
Author(s):  
Stefano Volpi ◽  
Umberto Cancelli ◽  
Martina Neri ◽  
Roberto Corradini
Keyword(s):  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Therapeutic Strategies ◽  
Delivery Systems ◽  
Cellular Systems ◽  
Polymer Nanoparticles ◽  
Supramolecular Systems ◽  
Porous Nanoparticles ◽  
Carbon Based

The number of applications of peptide nucleic acids (PNAs)—oligonucleotide analogs with a polyamide backbone—is continuously increasing in both in vitro and cellular systems and, parallel to this, delivery systems able to bring PNAs to their targets have been developed. This review is intended to give to the readers an overview on the available carriers for these oligonucleotide mimics, with a particular emphasis on newly developed multi-component- and multifunctional vehicles which boosted PNA research in recent years. The following approaches will be discussed: (a) conjugation with carrier molecules and peptides; (b) liposome formulations; (c) polymer nanoparticles; (d) inorganic porous nanoparticles; (e) carbon based nanocarriers; and (f) self-assembled and supramolecular systems. New therapeutic strategies enabled by the combination of PNA and proper delivery systems are discussed.

Selective inhibition of mutant human mitochondrial DNA replication in vitro by peptide nucleic acids

1997 ◽  
Vol 15 (2) ◽  
pp. 212-215 ◽  
Author(s):  
Robert W. Taylor ◽  
Patrick F. Chinnery ◽  
Douglass M. Turnbull ◽  
Robert N. Lightowlers
Keyword(s):  
Mitochondrial Dna ◽  
Dna Replication ◽  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Selective Inhibition ◽  
Human Mitochondrial Dna ◽  
Mitochondrial Dna Replication

In vitro stability of α-Helical peptide nucleic acids (αPNAs)

2001 ◽  
Vol 11 (17) ◽  
pp. 2315-2317 ◽  
Author(s):  
Philip Garner ◽  
Benjamin Sherry ◽  
Sirkka Moilanen ◽  
Yumei Huang
Keyword(s):  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Helical Peptide ◽  
In Vitro Stability
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