scholarly journals Erratum: Corrigendum: Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model

2015 ◽  
Vol 17 (4) ◽  
pp. 532-532 ◽  
Author(s):  
Yifeng Xia ◽  
Narayana Yeddula ◽  
Mathias Leblanc ◽  
Eugene Ke ◽  
Yonghui Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Mouse Lung ◽  
Cancer Model ◽  
Lung Cancer Model

scholarly journals Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model

2012 ◽  
Vol 14 (3) ◽  
pp. 257-265 ◽  
Author(s):  
Yifeng Xia ◽  
Narayana Yeddula ◽  
Mathias Leblanc ◽  
Eugene Ke ◽  
Yonghui Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Mouse Lung ◽  
Cancer Model ◽  
Lung Cancer Model

scholarly journals DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model

Gene Therapy ◽  
2014 ◽  
Vol 21 (10) ◽  
pp. 888-896 ◽  
Author(s):  
T-Y Weng ◽  
M-C Yen ◽  
C-T Huang ◽  
J-J Hung ◽  
Y-L Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Transgenic Mouse ◽  
Dna Vaccine ◽  
Mouse Lung ◽  
Cancer Model ◽  
Antitumor Response ◽  
Lung Cancer Model

scholarly journals Combination Therapy of VEGF-Trap and Gemcitabine Results in Improved Anti-Tumor Efficacy in a Mouse Lung Cancer Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e68589 ◽  
Author(s):  
Shuang Zhou ◽  
Yang Yang ◽  
Yaoqin Yang ◽  
Huihong Tao ◽  
Dong Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Combination Therapy ◽  
Mouse Lung ◽  
Cancer Model ◽  
Lung Cancer Model ◽  
Vegf Trap

Immunocell Therapy for Lung Cancer: Dendritic Cell Based Adjuvant Therapy in Mouse Lung Cancer Model

2005 ◽  
Vol 5 (1) ◽  
pp. 36 ◽  
Author(s):  
Seog Jae Lee ◽  
Myung Joo Kim ◽  
So Hee In ◽  
Soyoung Baek ◽  
Hyunah Lee
Keyword(s):  
Lung Cancer ◽  
Dendritic Cell ◽  
Adjuvant Therapy ◽  
Mouse Lung ◽  
Cancer Model ◽  
Lung Cancer Model

scholarly journals Overcoming resistance to anti-PD immunotherapy in a syngeneic mouse lung cancer model using locoregional virotherapy

2017 ◽  
Vol 7 (1) ◽  
pp. e1376156 ◽  
Author(s):  
Xiang Yan ◽  
Li Wang ◽  
Ran Zhang ◽  
Xingxiang Pu ◽  
Shuhong Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mouse Lung ◽  
Cancer Model ◽  
Syngeneic Mouse ◽  
Lung Cancer Model

scholarly journals Olaparib increases the therapeutic index of hemithoracic irradiation compared with hemithoracic irradiation alone in a mouse lung cancer model

2021 ◽  
Author(s):  
Yanyan Jiang ◽  
Jennifer Martin ◽  
Maryam Alkadhimi ◽  
Kay Shigemori ◽  
Paul Kinchesh ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Body Weight ◽  
Normal Tissue ◽  
Intervention Studies ◽  
Therapeutic Index ◽  
Mouse Lung ◽  
Cancer Model ◽  
Tissue Effects ◽  
Late Intervention ◽  
Lung Cancer Model

Abstract Background The radiosensitising effect of the poly(ADP-ribose) polymerase inhibitor olaparib on tumours has been reported. However, its effect on normal tissues in combination with radiation has not been well studied. Herein, we investigated the therapeutic index of olaparib combined with hemithoracic radiation in a urethane-induced mouse lung cancer model. Methods To assess tolerability, A/J mice were treated with olaparib plus whole thorax radiation (13 Gy), body weight changes were monitored and normal tissue effects were assessed by histology. In anti-tumour (intervention) studies, A/J mice were injected with urethane to induce lung tumours, and were then treated with olaparib alone, left thorax radiation alone or the combination of olaparib plus left thorax radiation at 8 weeks (early intervention) or 18 weeks (late intervention) after urethane injection. Anti-tumour efficacy and normal tissue effects were assessed by visual inspection, magnetic resonance imaging and histology. Results Enhanced body weight loss and oesophageal toxicity were observed when olaparib was combined with whole thorax but not hemithorax radiation. In both the early and late intervention studies, olaparib increased the anti-tumour effects of hemithoracic irradiation without increasing lung toxicity. Conclusions The addition of olaparib increased the therapeutic index of hemithoracic radiation in a mouse model of lung cancer.

Sign in / Sign up

Export Citation Format

Share Document