scholarly journals ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling

2014 ◽  
Vol 16 (10) ◽  
pp. 1004-1015 ◽  
Author(s):  
Rumela Chakrabarti ◽  
Yong Wei ◽  
Julie Hwang ◽  
Xiang Hang ◽  
Mario Andres Blanco ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Mammary Gland ◽  
Mammary Gland Development ◽  
Cell Activity ◽  
Wnt Signalling ◽  
Stem Cell Activity ◽  
Basal Like Breast Cancer ◽  
Gland Development

scholarly journals Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2

Stem Cells ◽  
2013 ◽  
Vol 31 (9) ◽  
pp. 1921-1931 ◽  
Author(s):  
Ying Wang ◽  
Jie Dong ◽  
Dali Li ◽  
Li Lai ◽  
Stefan Siwko ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Stem Cell ◽  
Mammary Gland ◽  
Mammary Gland Development ◽  
Cell Activity ◽  
Stem Cell Activity ◽  
Gland Development

scholarly journals Early Steps of Mammary Stem Cell Transformation by Exogenous Signals; Effects of Bisphenol Endocrine Disrupting Chemicals and Bone Morphogenetic Proteins

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1351 ◽  
Author(s):  
Nora Jung ◽  
Veronique Maguer-Satta ◽  
Boris Guyot
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Mammary Gland ◽  
Bone Morphogenetic Proteins ◽  
Mammary Gland Development ◽  
Cell Transformation ◽  
Current Knowledge ◽  
Endocrine Disrupting Chemicals ◽  
Normal Mammary Gland ◽  
Gland Development

Estrogens are major regulators of the mammary gland development, notably during puberty, via estrogen receptor (ER) activation, leading to the proliferation and differentiation of mammary cells. In addition to estrogens, the bone morphogenetic proteins (BMPs) family is involved in breast stem cell/progenitor commitment. However, these two pathways that synergistically contribute to the biology of the normal mammary gland have also been described to initiate and/or promote breast cancer development. In addition to intrinsic events, lifestyle habits and exposure to environmental cues are key risk factors for cancer in general, and especially for breast cancer. In the latter case, bisphenol A (BPA), an estrogen-mimetic compound, is a critical pollutant both in terms of the quantities released in our environment and of its known and speculated effects on mammary gland biology. In this review, we summarize the current knowledge on the actions of BMPs and estrogens in both normal mammary gland development and breast cancer initiation, dissemination, and resistance to treatment, focusing on the dysregulations of these processes by BPA but also by other bisphenols, including BPS and BPF, initially considered as safer alternatives to BPA.

The bone metastatic niche promotes breast cancer stem cell activity via IL-1β-Wnt signalling

2016 ◽  
Vol 61 ◽  
pp. S65
Author(s):  
R. Eyre ◽  
K. Spence ◽  
D. Alferez ◽  
A. Santiago-Gomez ◽  
C. Hart ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Activity ◽  
Wnt Signalling ◽  
Breast Cancer Stem Cell ◽  
Metastatic Niche ◽  
Stem Cell Activity

The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells

2015 ◽  
Vol 357 (1) ◽  
pp. 206-218 ◽  
Author(s):  
Saeb Aliwaini ◽  
Jade Peres ◽  
Wendy L. Kröger ◽  
Angelique Blanckenberg ◽  
Jo de la Mare ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cell Activity ◽  
Anti Cancer ◽  
Stem Cell Activity

scholarly journals Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor

2010 ◽  
Vol 70 (2) ◽  
pp. 709-718 ◽  
Author(s):  
Hannah Harrison ◽  
Gillian Farnie ◽  
Sacha J. Howell ◽  
Rebecca E. Rock ◽  
Spyros Stylianou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Activity ◽  
Breast Cancer Stem Cell ◽  
Stem Cell Activity
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