scholarly journals Erratum: Role of the SIK2–p35–PJA2 complex in pancreatic β-cell functional compensation

2014 ◽  
Vol 16 (4) ◽  
pp. 382-382
Author(s):  
Jun-Ichi Sakamaki ◽  
Accalia Fu ◽  
Courtney Reeks ◽  
Stephen Baird ◽  
Chantal Depatie ◽  
...  
Keyword(s):  
Pancreatic Β Cell ◽  
Β Cell ◽  
Functional Compensation

scholarly journals Role of the SIK2–p35–PJA2 complex in pancreatic β-cell functional compensation

2014 ◽  
Vol 16 (3) ◽  
pp. 234-244 ◽  
Author(s):  
Jun-Ichi Sakamaki ◽  
Accalia Fu ◽  
Courtney Reeks ◽  
Stephen Baird ◽  
Chantal Depatie ◽  
...  
Keyword(s):  
Pancreatic Β Cell ◽  
Β Cell ◽  
Functional Compensation

scholarly journals Erratum: Corrigendum: Role of the SIK2–p35–PJA2 complex in pancreatic β-cell functional compensation

2014 ◽  
Vol 16 (4) ◽  
pp. 382-382
Author(s):  
Jun-Ichi Sakamaki ◽  
Accalia Fu ◽  
Courtney Reeks ◽  
Stephen Baird ◽  
Chantal Depatie ◽  
...  
Keyword(s):  
Pancreatic Β Cell ◽  
Β Cell ◽  
Functional Compensation

Role of Ca2+ in alloxan-induced pancreatic β-cell damage

1994 ◽  
Vol 1227 (1-2) ◽  
pp. 87-91 ◽  
Author(s):  
Hyung-Rho Kim ◽  
Hye-Won Rho ◽  
Byung-Hyun Park ◽  
Jin-Woo Park ◽  
Jong-Suk Kim ◽  
...  
Keyword(s):  
Cell Damage ◽  
Pancreatic Β Cell ◽  
Β Cell

scholarly journals Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation

2012 ◽  
pp. 235-243 ◽  
Author(s):  
Norman Balcazar Morales ◽  
Cecilia Aguilar de Plata
Keyword(s):  
Cell Cycle ◽  
Growth Factors ◽  
Cell Cycle Progression ◽  
Cell Mass ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Cycle Progression ◽  
Mtorc1 Signaling

Growth factors, insulin signaling and nutrients are important regulators of β-cell mass and function. The events linking these signals to regulation of β-cell mass are not completely understood. Recent findings indicate that mTOR pathway integrates signals from growth factors and nutrients with transcription, translation, cell size, cytoskeleton remodeling and mitochondrial metabolism. mTOR is a part of two distinct complexes; mTORC1 and mTORC2. The mammalian TORC1 is sensitive to rapamycin and contains Raptor, deptor, PRAS40 and the G protein β-subunit-like protein (GβL). mTORC1 activates key regulators of protein translation; ribosomal S6 kinase (S6K) and eukaryote initiation factor 4E-binding protein 1. This review summarizes current findings about the role of AKT/mTORC1 signaling in regulation of pancreatic β cell mass and proliferation. mTORC1 is a major regulator of β-cell cycle progression by modulation of cyclins D2, D3 and cdk4/cyclin D activity. These studies uncovered key novel pathways controlling cell cycle progression in β-cells in vivo. This information can be used to develop alternative approaches to expand β-cell mass in vivo and in vitro without the risk of oncogenic transformation. The acquisition of such knowledge is critical for the design of improved therapeutic strategies for the treatment and cure of diabetes as well as to understand the effects of mTOR inhibitors in β-cell function.

The role of aging and senescence on pancreatic β-cell function and proliferation

2017 ◽  
Vol 108 ◽  
pp. S71
Author(s):  
Richard Kehm ◽  
Oliver Kluth ◽  
Annette Schürmann ◽  
Tilman Grune ◽  
Annika Höhn
Keyword(s):  
Cell Function ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Β Cell Function

scholarly journals Role of TRPV channels in regulating various pancreatic β-cell functions: Lessons from in vitro studies

2017 ◽  
Vol 11 (1) ◽  
pp. 9-15
Author(s):  
Marek Skrzypski ◽  
Maria Billert ◽  
Stefan Mergler ◽  
Noushafarin Khajavi ◽  
Krzysztof W. Nowak ◽  
...  
Keyword(s):  
Pancreatic Β Cell ◽  
Β Cell ◽  
Cell Functions ◽  
Trpv Channels
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