scholarly journals Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes

2013 ◽  
Vol 15 (12) ◽  
pp. 1415-1423 ◽  
Author(s):  
Jing Chen ◽  
Simona Torcia ◽  
Fang Xie ◽  
Chih-Jen Lin ◽  
Hakan Cakmak ◽  
...  
Keyword(s):  
Somatic Cells ◽  
Mrna Translation ◽  
Developmental Competence ◽  
Mouse Oocytes ◽  
Maternal Mrna

scholarly journals FSH Regulates mRNA Translation in Mouse Oocytes and Promotes Developmental Competence

Endocrinology ◽  
2015 ◽  
Vol 157 (2) ◽  
pp. 872-882 ◽  
Author(s):  
Federica Franciosi ◽  
Shila Manandhar ◽  
Marco Conti
Keyword(s):  
Mrna Translation ◽  
Developmental Competence ◽  
Mouse Oocytes

Oocyte Maternal mRNA Translation and Developmental Competence: A Genome-Wide Analysis.

2012 ◽  
Vol 87 (Suppl_1) ◽  
pp. 88-88 ◽  
Author(s):  
Marco Conti ◽  
Jing Chen ◽  
Fang Xie ◽  
Chi-Jen Lin ◽  
Kathleen Horner
Keyword(s):  
Mrna Translation ◽  
Developmental Competence ◽  
Genome Wide Analysis ◽  
Maternal Mrna ◽  
Genome Wide ◽  
A Genome

scholarly journals Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells

2016 ◽  
Vol 113 (9) ◽  
pp. 2424-2429 ◽  
Author(s):  
Hakan Cakmak ◽  
Federica Franciosi ◽  
A. Musa Zamah ◽  
Marcelle I. Cedars ◽  
Marco Conti
Keyword(s):  
Cell Cycle ◽  
Follicular Fluid ◽  
Ovarian Follicle ◽  
Somatic Cells ◽  
Cumulus Cell ◽  
Mrna Translation ◽  
Developmental Competence ◽  
Bioactive Molecules ◽  
Current View ◽  
Paracrine Factors

The differentiation of the female gamete into a developmentally competent oocyte relies on the protected environment of the ovarian follicle. The oocyte plays a key role in establishing this microenvironment by releasing paracrine factors that control the functions of surrounding somatic cells. Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are secreted during follicle growth and play pivotal roles in this local regulation. The current view is that the function of these secreted factors declines in the periovulatory period when the oocyte reenters the meiotic cell cycle. Here, we provide evidence that oocyte reentry into meiosis is instead associated with a shift in the pattern of secretion with a new set of bioactive molecules synthesized before ovulation. Using interleukin 7 (IL7) as a prototypic secreted factor, we show that its secretion is dependent on activation of mRNA translation in synchrony with the cell cycle and that its translation is under the control of somatic cells. IL7 is part of a local feedback loop with the soma because it regulates cumulus cell replication. Similar conclusions are reached when IL7 secretion is measured in human follicular fluid during in vitro fertilization cycles. IL7 concentration in the follicular fluid correlates with the oocyte ability to reach the MII stage of maturation. These findings are consistent with the hypothesis that a new set of local factors is secreted by the oocyte during ovulation. These dynamic secretions are likely critical for promoting the final stages of maturation and oocyte developmental competence.

scholarly journals A MAPK cascade couples maternal mRNA translation and degradation to meiotic cell cycle progression in mouse oocytes

Development ◽  
2016 ◽  
Vol 144 (3) ◽  
pp. 452-463 ◽  
Author(s):  
Qian-Qian Sha ◽  
Xing-Xing Dai ◽  
Yujiao Dang ◽  
Fuchou Tang ◽  
Junping Liu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Mrna Translation ◽  
Mapk Cascade ◽  
Meiotic Cell ◽  
Cycle Progression ◽  
Mouse Oocytes ◽  
Maternal Mrna

Conditions that affect acquisition of developmental competence by mouse oocytes in vitro: FSH, insulin, glucose and ascorbic acid

2000 ◽  
Vol 163 (1-2) ◽  
pp. 109-116 ◽  
Author(s):  
John J Eppig ◽  
Misa Hosoe ◽  
Marilyn J O’Brien ◽  
Frank M Pendola ◽  
Antonio Requena ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Developmental Competence ◽  
Mouse Oocytes

Synthesis and phosphorylation of uvomorulin during mouse early development

Development ◽  
1992 ◽  
Vol 115 (1) ◽  
pp. 313-318 ◽  
Author(s):  
M. Sefton ◽  
M.H. Johnson ◽  
L. Clayton
Keyword(s):  
Cell Adhesion ◽  
Early Development ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Blastocyst Stage ◽  
Embryonic Stage ◽  
Cell Stage ◽  
Mouse Oocytes ◽  
Maternal Mrna ◽  
Embryonic Genome

The cell adhesion molecule, uvomorulin, is synthesised in both the 135 × 10(3) M(r) precursor and 120 × 10(3) M(r) mature forms on maternal mRNA templates in unfertilized and newly fertilized mouse oocytes. Synthesis on maternal message ceases during the 2-cell stage to resume later on mRNA encoded presumptively by the embryonic genome. Uvomorulin is detectable by immunoblotting at all stages upto the blastocyst stage, but shows variations in its total amount and processing with embryonic stage. Whilst only trace levels of phosphorylated uvomorulin are detectable in early and late 4-cell embryos, uvomorulin in 8-cell embryos is phosphorylated.

scholarly journals The GNU subunit of PNG kinase, the developmental regulator of mRNA translation, binds BIC-C to localize to RNP granules

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Emir E Avilés-Pagán ◽  
Masatoshi Hara ◽  
Terry L Orr-Weaver
Keyword(s):  
Translational Regulation ◽  
Mrna Translation ◽  
Mature Oocyte ◽  
Early Embryogenesis ◽  
Egg Activation ◽  
Maternal Mrna ◽  
Rnp Granules

Control of mRNA translation is a key mechanism by which the differentiated oocyte transitions to a totipotent embryo. In Drosophila, the PNG kinase complex regulates maternal mRNA translation at the oocyte-to-embryo transition. We previously showed the GNU activating subunit is crucial in regulating PNG and timing its activity to the window between egg activation and early embryogenesis (Hara et al., 2017). In this study, we find associations between GNU and proteins of RNP granules and demonstrate that GNU localizes to cytoplasmic RNP granules in the mature oocyte, identifying GNU as a new component of a subset of RNP granules. Furthermore, we define roles for the domains of GNU. Interactions between GNU and the granule component BIC-C reveal potential conserved functions for translational regulation in metazoan development. We propose that by binding to BIC-C, upon egg activation GNU brings PNG to its initial targets, translational repressors in RNP granules.

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