scholarly journals Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration

2013 ◽  
Vol 15 (2) ◽  
pp. 222-228 ◽  
Author(s):  
Nick R. Love ◽  
Yaoyao Chen ◽  
Shoko Ishibashi ◽  
Paraskevi Kritsiligkou ◽  
Robert Lea ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Tail Regeneration ◽  
Xenopus Tadpole ◽  
Tadpole Tail

scholarly journals Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells

2018 ◽  
Author(s):  
Maria Montserrat Garcia Romero ◽  
Gareth McCathie ◽  
Philip Jankun ◽  
Henry Hamilton Roehl
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Tail Regeneration ◽  
Damage Site ◽  
Hedgehog Signalling ◽  
Ability To Regenerate ◽  
Aquatic Vertebrates ◽  
Notochord Cells ◽  
Developmental Signalling

AbstractAquatic vertebrates have a remarkable ability to regenerate limbs and tails after amputation. Previous studies indicate that reactive oxygen species (ROS) signaling initiates regeneration, but the mechanism by which this takes place is poorly understood. Developmental signalling pathways have been shown to have pro-regenerative roles in many systems. However, whether these are playing roles that are specific to regeneration, or are simply recapitulating their developmental functions is unclear. We have analysed zebrafish larval tail regeneration and find evidence that ROS released upon wounding cause repositioning of notochord cells to the damage site. These cells secrete Hedgehog ligands which are required for regeneration. Hedgehog signalling is not required for normal tail development suggesting that it has a regeneration specific role. Our results provide a model for how ROS initiate tail regeneration, and indicate that developmental signaling pathways can play regenerative functions that are not directly related to their developmental roles.

scholarly journals Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Maria Montserrat Garcia Romero ◽  
Gareth McCathie ◽  
Philip Jankun ◽  
Henry Hamilton Roehl
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Tail Regeneration

scholarly journals Bacteria are required for regeneration of the Xenopus tadpole tail

2018 ◽  
Author(s):  
Thomas F. Bishop ◽  
Caroline W. Beck
Keyword(s):  
Reactive Oxygen Species ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Oxygen Species ◽  
Transcription Factor Activity ◽  
Factor Activity ◽  
Regenerative Processes ◽  
Tail Regeneration ◽  
Positive Feedback Loop ◽  
Tadpole Tail

AbstractThe impressive regenerative capabilities of amphibians have been studied for over a century. Although we have learnt a great deal about regenerative processes, the factors responsible for the initiation of regeneration have remained elusive. A previous study implicated reactive oxygen species (ROS) and the ROS-generator, NADPH oxidase (Nox), in Xenopus tadpole tail regeneration. In this study we suggest that Nox is expressed as a consequence of NF-κB transcription factor activity and that ROS produced by Nox, in turn, help to maintain the activity of NF-κB, forming a positive-feedback loop. Microorganisms were found to be required for regeneration through binding to toll-like receptors (TLR). NF-κB is a downstream component of TLR pathways and its activation through TLR stimulation could jump-start the positive-feedback loop. These findings provide potential targets for the activation of regeneration in non-regenerative animals.

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