scholarly journals The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

2011 ◽  
Vol 13 (8) ◽  
pp. 877-883 ◽  
Author(s):  
Bin Zhao ◽  
Karen Tumaneng ◽  
Kun-Liang Guan
Keyword(s):  
Stem Cell ◽  
Tissue Regeneration ◽  
Hippo Pathway ◽  
Size Control ◽  
Organ Size ◽  
Self Renewal ◽  
Control Tissue ◽  
The Hippo Pathway

scholarly journals Localized JNK signaling regulates organ size during development

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Helen Rankin Willsey ◽  
Xiaoyan Zheng ◽  
José Carlos Pastor-Pareja ◽  
A Jeremy Willsey ◽  
Philip A Beachy ◽  
...  
Keyword(s):  
Hedgehog Signaling ◽  
Hippo Pathway ◽  
Size Control ◽  
Organ Size ◽  
Control Mechanisms ◽  
Cancer Therapies ◽  
Independent Manner ◽  
Jnk Signaling ◽  
New Strategy ◽  
The Hippo Pathway

A fundamental question of biology is what determines organ size. Despite demonstrations that factors within organs determine their sizes, intrinsic size control mechanisms remain elusive. Here we show that Drosophila wing size is regulated by JNK signaling during development. JNK is active in a stripe along the center of developing wings, and modulating JNK signaling within this stripe changes organ size. This JNK stripe influences proliferation in a non-canonical, Jun-independent manner by inhibiting the Hippo pathway. Localized JNK activity is established by Hedgehog signaling, where Ci elevates dTRAF1 expression. As the dTRAF1 homolog, TRAF4, is amplified in numerous cancers, these findings provide a new mechanism for how the Hedgehog pathway could contribute to tumorigenesis, and, more importantly, provides a new strategy for cancer therapies. Finally, modulation of JNK signaling centers in developing antennae and legs changes their sizes, suggesting a more generalizable role for JNK signaling in developmental organ size control.

scholarly journals The Hippo pathway regulates stem cell proliferation, self-renewal, and differentiation

2012 ◽  
Vol 3 (4) ◽  
pp. 291-304 ◽  
Author(s):  
Huan Liu ◽  
Dandan Jiang ◽  
Fangtao Chi ◽  
Bin Zhao
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Hippo Pathway ◽  
Self Renewal ◽  
Stem Cell Proliferation ◽  
The Hippo Pathway

scholarly journals Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

Cell ◽  
2015 ◽  
Vol 163 (4) ◽  
pp. 811-828 ◽  
Author(s):  
Fa-Xing Yu ◽  
Bin Zhao ◽  
Kun-Liang Guan
Keyword(s):  
Hippo Pathway ◽  
Size Control ◽  
Tissue Homeostasis ◽  
Organ Size ◽  
Control Tissue

scholarly journals Regulation and functions of the Hippo pathway in stemness and differentiation

2020 ◽  
Vol 52 (7) ◽  
pp. 736-748 ◽  
Author(s):  
Xiaolei Cao ◽  
Chenliang Wang ◽  
Jiyang Liu ◽  
Bin Zhao
Keyword(s):  
Cell Proliferation ◽  
Tissue Regeneration ◽  
Hippo Pathway ◽  
Binding Motif ◽  
Cell Fates ◽  
Self Renewal ◽  
Proliferation And Apoptosis ◽  
Kinase Cascade ◽  
The Hippo Pathway

Abstract The Hippo pathway plays important roles in organ development, tissue regeneration, and human diseases, such as cancer. In the canonical Hippo pathway, the MST1/2-LATS1/2 kinase cascade phosphorylates and inhibits transcription coactivators Yes-associated protein and transcription coactivator with PDZ-binding motif and thus regulates transcription of genes important for cell proliferation and apoptosis. However, recent studies have depicted a much more complicate picture of the Hippo pathway with many new components and regulatory stimuli involving both chemical and mechanical signals. Furthermore, accumulating evidence indicates that the Hippo pathway also plays important roles in the determination of cell fates, such as self-renewal and differentiation. Here, we review regulations of the Hippo pathway and its functions in stemness and differentiation emphasizing recent discoveries.

scholarly journals Cultured cells and wing disc size of silkworm can be controlled by the Hippo pathway

Open Biology ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. 180029 ◽  
Author(s):  
Zi Liang ◽  
Yahong Lu ◽  
Ying Qian ◽  
Liyuan Zhu ◽  
Sulan Kuang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cultured Cells ◽  
Hippo Pathway ◽  
Size Control ◽  
Wing Disc ◽  
Organ Size ◽  
Promote Cell Proliferation ◽  
A Cell ◽  
The Hippo Pathway ◽  
Disc Size

Hippo signalling represents a cell proliferation and organ-size control pathway. Yorki (Yki), a component of the Hippo pathway, induces the transcription of a number of targets that promote cell proliferation and survival. The functions of Yki have been characterized in Drosophila and mammals, while there are few reports on silkworm, Bombyx mori . In the present study, we found that BmYki3 facilitates cell migration and cell division, and enlarges the cultured cell and wing disc size. Co-immunoprecipitation results indicated that BmYki3 may interact with thymosin, E3 ubiquitin-protein ligase, protein kinase ASK1, dedicator of cytokinesis protein 1, calcium-independent phospholipase A2 and beta-spectrin. RNA-seq results indicated that 4444 genes were upregulated and 10 291 genes were downregulated after BmYki3 was overexpressed in the cultured cells. GO annotation indicated that the up/downregulated genes were enriched in 268/382 GO terms ( p < 0.01); KEGG analysis showed that the up/downregulated genes were enriched in 49/101 pathways. These findings provided novel information to understand the functions of BmYki3 in a cell proliferation and organ-size control pathway.

scholarly journals The Hippo pathway: key interaction and catalytic domains in organ growth control, stem cell self-renewal and tissue regeneration

2012 ◽  
Vol 53 ◽  
pp. 111-127 ◽  
Author(s):  
Claire Cherrett ◽  
Makoto Furutani-Seiki ◽  
Stefan Bagby
Keyword(s):  
Stem Cell ◽  
Hippo Pathway ◽  
Growth Control ◽  
Activation Function ◽  
Binding Motif ◽  
Self Renewal ◽  
Organ Growth ◽  
Co Activation ◽  
Multiple Processes ◽  
The Hippo Pathway

The Hippo pathway is a conserved pathway that interconnects with several other pathways to regulate organ growth, tissue homoeostasis and regeneration, and stem cell self-renewal. This pathway is unique in its capacity to orchestrate multiple processes, from sensing to execution, necessary for organ expansion. Activation of the Hippo pathway core kinase cassette leads to cytoplasmic sequestration of the nuclear effectors YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif), consequently disabling their transcriptional co-activation function. Components upstream of the core kinase cassette have not been well understood, especially in vertebrates, but are gradually being elucidated and include cell polarity and cell adhesion proteins.

scholarly journals Context-dependent transcriptional regulations of YAP/TAZ in stem cell and differentiation

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Juan Luo ◽  
Peng Li
Keyword(s):  
Stem Cell ◽  
Tissue Regeneration ◽  
Hippo Pathway ◽  
Size Control ◽  
Future Directions ◽  
The Core ◽  
Downstream Effectors ◽  
Potential Applications ◽  
Core Components ◽  
Transcriptional Output

AbstractHippo pathway is initially identified as a master regulator for cell proliferation and organ size control, and the subsequent researches show this pathway is also involved in development, tissue regeneration and homeostasis, inflammation, immunity and cancer. YAP/TAZ, the downstream effectors of Hippo pathway, usually act as coactivators and are dependent on other transcription factors to mediate their transcriptional outputs. In this review, we will first provide an overview on the core components and regulations of Hippo pathway in mammals, and then systematically summarize the identified transcriptional factors or partners that are responsible for the transcriptional output of YAP/TAZ in stem cell and differentiation. More than that, we will discuss the potential applications and future directions based on these findings.

scholarly journals Pits and CtBP control tissue growth in Drosophila melanogaster with the Hippo pathway transcription repressor, Tgi

2019 ◽  
Author(s):  
Joseph H.A. Vissers ◽  
Lucas G. Dent ◽  
Colin House ◽  
Shu Kondo ◽  
Kieran F. Harvey
Keyword(s):  
Cell Fate ◽  
Transcriptional Repression ◽  
Target Genes ◽  
Affinity Purification ◽  
Hippo Pathway ◽  
Transcriptional Response ◽  
Size Control ◽  
Tissue Growth ◽  
Organ Size ◽  
The Hippo Pathway

ABSTRACTThe Hippo pathway is an evolutionary conserved signalling network that regulates organ size, cell fate control and tumorigenesis. In the context of organ size control, the pathway incorporates a large variety of cellular cues such as cell polarity and adhesion into an integrated transcriptional response. The central Hippo signalling effector is the transcriptional co-activator Yorkie, which controls gene expression in partnership with different transcription factors, most notably Scalloped. When it is not activated by Yorkie, Scalloped can act as a repressor of transcription, at least in part due to its interaction with the corepressor protein Tgi. The mechanism by which Tgi represses transcription is incompletely understood and therefore we sought to identify proteins that potentially operate together with it. Using an affinity purification and mass-spectrometry approach we identified Pits and CtBP as Tgi-interacting proteins, both of which have been linked to transcriptional repression. Both Pits and CtBP were required for Tgi to suppress the growth of the D. melanogaster eye and CtBP loss suppressed the undergrowth of yorkie mutant eye tissue. Furthermore, as reported previously for Tgi, overexpression of Pits suppressed transcription of Hippo pathway target genes. These findings suggest that Tgi might operate together with Pits and CtBP to repress transcription of genes that normally promote tissue growth. The human orthologues of Tgi, CtBP and Pits (VGLL4, CTBP2 and IRF2BP2) physically and functionally interact to control transcription, implying that the mechanism by which these proteins control transcriptional repression is conserved throughout evolution.

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