scholarly journals Mitotic internalization of planar cell polarity proteins preserves tissue polarity

2011 ◽  
Vol 13 (8) ◽  
pp. 893-902 ◽  
Author(s):  
Danelle Devenport ◽  
Daniel Oristian ◽  
Evan Heller ◽  
Elaine Fuchs
Keyword(s):  
Cell Polarity ◽  
Planar Cell Polarity ◽  
Tissue Polarity ◽  
Polarity Proteins

scholarly journals Erratum: Corrigendum: Mitotic internalization of planar cell polarity proteins preserves tissue polarity

2017 ◽  
Vol 19 (2) ◽  
pp. 143-143
Author(s):  
Danelle Devenport ◽  
Daniel Oristian ◽  
Evan Heller ◽  
Elaine Fuchs
Keyword(s):  
Cell Polarity ◽  
Planar Cell Polarity ◽  
Tissue Polarity ◽  
Polarity Proteins

scholarly journals Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation

2013 ◽  
Vol 383 (1) ◽  
pp. 39-51 ◽  
Author(s):  
Michael R. Dohn ◽  
Nathan A. Mundell ◽  
Leah M. Sawyer ◽  
Julie A. Dunlap ◽  
Jason R. Jessen
Keyword(s):  
Extracellular Matrix ◽  
Cell Polarity ◽  
Planar Cell Polarity ◽  
Matrix Organization ◽  
Polarity Proteins

scholarly journals Celsr1 and CAMSAP3 differently regulate intercellular and intracellular cilia orientation in oviduct multiciliated cells

2020 ◽  
Author(s):  
Fumiko Matsukawa Usami ◽  
Masaki Arata ◽  
Dongbo Shi ◽  
Sanae Oka ◽  
Yoko Higuchi ◽  
...  
Keyword(s):  
Cell Polarity ◽  
Planar Cell Polarity ◽  
Molecular Mechanisms ◽  
The Other ◽  
Basal Bodies ◽  
Generating Functional ◽  
Tissue Polarity ◽  
Other Hand ◽  
Multiciliated Cells ◽  
Polarity Regulation

SummaryThe molecular mechanisms by which cilia orientation is coordinated within and between multiciliated cells (MCCs) is not fully understood. By observing the orientation of basal bodies (BB) in MCCs of mouse oviducts, here, we show that Celsr1, a planar cell polarity (PCP) factor involved in tissue polarity regulation, is dispensable for determining BB orientation in individual cells, whereas CAMSAP3, a microtubule minus-end regulator, is critical for this process but not for PCP. MCCs exhibit a characteristic BB orientation and microtubule gradient along the tissue axis, and these intracellular polarities were maintained in the cells lacking Celsr1, although the intercellular coordination of the polarities was partly disrupted. On the other hand, CAMSAP3 regulated the assembly of microtubules interconnecting BBs by localizing at the BBs, and its mutation led to disruption of intracellular coordination of BB orientation, but not affecting PCP factor localization. Thus, both Celsr1 and CAMSAP3 are responsible for BB orientation but in distinct ways; and therefore, their cooperation should be critical for generating functional multiciliated tissues.

scholarly journals Planar Cell Polarity Signaling Pathway in Congenital Heart Diseases

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Gang Wu ◽  
Jiao Ge ◽  
Xupei Huang ◽  
Yimin Hua ◽  
Dezhi Mu
Keyword(s):  
Signaling Pathway ◽  
Cell Polarity ◽  
Congenital Heart ◽  
Planar Cell Polarity ◽  
Heart Diseases ◽  
Multiple Roles ◽  
Cardiac Differentiation ◽  
Tissue Polarity ◽  
Cardiac Disorder ◽  
Pcp Signaling

Congenital heart disease (CHD) is a common cardiac disorder in humans. Despite many advances in the understanding of CHD and the identification of many associated genes, the fundamental etiology for the majority of cases remains unclear. The planar cell polarity (PCP) signaling pathway, responsible for tissue polarity inDrosophilaand gastrulation movements and cardiogenesis in vertebrates, has been shown to play multiple roles during cardiac differentiation and development. The disrupted function of PCP signaling is connected to some CHDs. Here, we summarize our current understanding of how PCP factors affect the pathogenesis of CHD.

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