Human zinc fingers as building blocks in the construction of artificial transcription factors

2003 ◽  
Vol 21 (3) ◽  
pp. 275-280 ◽  
Author(s):  
Kwang-Hee Bae ◽  
Young Do Kwon ◽  
Hyun-Chul Shin ◽  
Moon-Sun Hwang ◽  
Eun-Hyun Ryu ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Zinc Fingers ◽  
Building Blocks ◽  
Artificial Transcription Factors

scholarly journals Erratum: Corrigendum: Human zinc fingers as building blocks in the construction of artificial transcription factors

2003 ◽  
Vol 21 (4) ◽  
pp. 452-452
Author(s):  
Kwang-Hee Bae ◽  
Young Do Kwon ◽  
Hyun-Chul Shin ◽  
Moon-Sun Hwang ◽  
Eun-Hyun Ryu ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Zinc Fingers ◽  
Building Blocks ◽  
Artificial Transcription Factors

scholarly journals Targeting Artificial Transcription Factors to the Utrophin A Promoter

2008 ◽  
Vol 283 (50) ◽  
pp. 34720-34727 ◽  
Author(s):  
Yifan Lu ◽  
Chai Tian ◽  
Gawiyou Danialou ◽  
Rénald Gilbert ◽  
Basil J. Petrof ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Artificial Transcription Factors

scholarly journals Reprogramming cell fate with artificial transcription factors

FEBS Letters ◽  
2018 ◽  
Vol 592 (6) ◽  
pp. 888-900 ◽  
Author(s):  
Evan A. Heiderscheit ◽  
Asuka Eguchi ◽  
Mackenzie C. Spurgat ◽  
Aseem Z. Ansari
Keyword(s):  
Transcription Factors ◽  
Cell Fate ◽  
Artificial Transcription Factors

scholarly journals The natural history of the WRKY–GCM1 zinc fingers and the relationship between transcription factors and transposons

2006 ◽  
Vol 34 (22) ◽  
pp. 6505-6520 ◽  
Author(s):  
M. Madan Babu ◽  
Lakshminarayan M. Iyer ◽  
S. Balaji ◽  
L. Aravind
Keyword(s):  
Transcription Factors ◽  
Natural History ◽  
Zinc Fingers ◽  
History Of ◽  
The Relationship

scholarly journals Modulation of endogenous VEGF-A expression by artificial transcription factors

2007 ◽  
Vol 51 (1) ◽  
pp. 345-346
Author(s):  
T. Mori ◽  
J. Sasaki ◽  
Y. Aoyama ◽  
T. Sera
Keyword(s):  
Transcription Factors ◽  
Artificial Transcription Factors

scholarly journals Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN

Science ◽  
2018 ◽  
Vol 362 (6414) ◽  
pp. eaat0572 ◽  
Author(s):  
Quinlan L. Sievers ◽  
Georg Petzold ◽  
Richard D. Bunker ◽  
Aline Renneville ◽  
Mikołaj Słabicki ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Small Molecules ◽  
Zinc Finger ◽  
Ubiquitin Ligase ◽  
Biochemical Analysis ◽  
Zinc Fingers ◽  
Functional Characterization ◽  
C2h2 Zinc Finger

The small molecules thalidomide, lenalidomide, and pomalidomide induce the ubiquitination and proteasomal degradation of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) by recruiting a Cys2-His2 (C2H2) zinc finger domain to Cereblon (CRBN), the substrate receptor of the CRL4CRBN E3 ubiquitin ligase. We screened the human C2H2 zinc finger proteome for degradation in the presence of thalidomide analogs, identifying 11 zinc finger degrons. Structural and functional characterization of the C2H2 zinc finger degrons demonstrates how diverse zinc finger domains bind the permissive drug-CRBN interface. Computational zinc finger docking and biochemical analysis predict that more than 150 zinc fingers bind the drug-CRBN complex in vitro, and we show that selective zinc finger degradation can be achieved through compound modifications. Our results provide a rationale for therapeutically targeting transcription factors that were previously considered undruggable.

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