scholarly journals Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells

2018 ◽  
Vol 36 (10) ◽  
pp. 962-970 ◽  
Author(s):  
Keren Bahar Halpern ◽  
Rom Shenhav ◽  
Hassan Massalha ◽  
Beata Toth ◽  
Adi Egozi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Liver Endothelial Cells ◽  
Gene Expression Mapping ◽  
Paired Cell

scholarly journals Stimulation of endothelin-1 gene expression by insulin in endothelial cells.

1991 ◽  
Vol 266 (34) ◽  
pp. 23251-23256
Author(s):  
F.J. Oliver ◽  
G. de la Rubia ◽  
E.P. Feener ◽  
M.E. Lee ◽  
M.R. Loeken ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Endothelin 1 ◽  
Stimulation Of

scholarly journals Activation of the S100A7/RAGE Pathway by IGF-1 Contributes to Angiogenesis in Breast Cancer

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 621
Author(s):  
Maria Grazia Muoio ◽  
Marianna Talia ◽  
Rosamaria Lappano ◽  
Andrew H. Sims ◽  
Veronica Vella ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Bioinformatic Analysis ◽  
Tube Formation ◽  
Endothelial Cell Proliferation ◽  
Diabetic Patients ◽  
Obesity And Diabetes ◽  
Er Positive

Background: Breast cancer (BC) mortality is increased among obese and diabetic patients. Both obesity and diabetes are associated with dysregulation of both the IGF-1R and the RAGE (Receptor for Advanced Glycation End Products) pathways, which contribute to complications of these disorders. The alarmin S100A7, signaling through the receptor RAGE, prompts angiogenesis, inflammation, and BC progression. Methods: We performed bioinformatic analysis of BC gene expression datasets from published studies. We then used Estrogen Receptor (ER)-positive BC cells, CRISPR-mediated IGF-1R KO BC cells, and isogenic S100A7-transduced BC cells to investigate the role of IGF-1/IGF-1R in the regulation of S100A7 expression and tumor angiogenesis. To this aim, we also used gene silencing and pharmacological inhibitors, and we performed gene expression and promoter studies, western blotting analysis, ChIP and ELISA assays, endothelial cell proliferation and tube formation assay. Results: S100A7 expression correlates with worse prognostic outcomes in human BCs. In BC cells, the IGF-1/IGF-1R signaling engages STAT3 activation and its recruitment to the S100A7 promoter toward S100A7 increase. In human vascular endothelial cells, S100A7 activates RAGE signaling and prompts angiogenic effects. Conclusions: In ER-positive BCs the IGF-1 dependent activation of the S100A7/RAGE signaling in adjacent endothelial cells may serve as a previously unidentified angiocrine effector. Targeting S100A7 may pave the way for a better control of BC, particularly in conditions of unopposed activation of the IGF-1/IGF-1R axis.

scholarly journals Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells

1991 ◽  
Vol 266 (24) ◽  
pp. 16188-16192 ◽  
Author(s):  
M.E. Lee ◽  
D.H. Temizer ◽  
J.A. Clifford ◽  
T. Quertermous
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Binding Protein ◽  
Endothelin 1

scholarly journals Chronic ethanol consumption impairs receptor-mediated endocytosis of MAA-modified albumin by liver endothelial cells

2003 ◽  
Vol 66 (6) ◽  
pp. 1045-1054 ◽  
Author(s):  
Michael J Duryee ◽  
Lynell W Klassen ◽  
Thomas L Freeman ◽  
Monte S Willis ◽  
Dean J Tuma ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Ethanol Consumption ◽  
Chronic Ethanol ◽  
Receptor Mediated Endocytosis ◽  
Chronic Ethanol Consumption ◽  
Liver Endothelial Cells

794 TLR1/2 LIGAND STIMULATED MOUSE LIVER ENDOTHELIAL CELLS PRODUCE IL-12 AND TRIGGER CD8+ T-CELL IMMUNITY

2012 ◽  
Vol 56 ◽  
pp. S311
Author(s):  
J. Liu ◽  
M. Jiang ◽  
Z. Ma ◽  
J. Schlaak ◽  
M. Roggendorf ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
T Cell ◽  
Mouse Liver ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Cell Immunity ◽  
Liver Endothelial Cells
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