Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

2012 ◽  
Vol 30 (12) ◽  
pp. 1210-1216 ◽  
Author(s):  
Benjamin Petsch ◽  
Margit Schnee ◽  
Annette B Vogel ◽  
Elke Lange ◽  
Bernd Hoffmann ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Protective Efficacy ◽  
Influenza A Virus Infection ◽  
Specific Mrna

scholarly journals Influenza A Virus Infection Induces Apical Redistribution of Na+, K+-ATPase in Lung Epithelial Cells In Vitro and In Vivo

2019 ◽  
Vol 61 (3) ◽  
pp. 395-398
Author(s):  
Christin Peteranderl ◽  
Irina Kuznetsova ◽  
Jessica Schulze ◽  
Martin Hardt ◽  
Emilia Lecuona ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Influenza A Virus Infection

Inhibition of Influenza A Virus Infection in Vitro by Saliphenylhalamide-Loaded Porous Silicon Nanoparticles

ACS Nano ◽  
2013 ◽  
Vol 7 (8) ◽  
pp. 6884-6893 ◽  
Author(s):  
Luis M. Bimbo ◽  
Oxana V. Denisova ◽  
Ermei Mäkilä ◽  
Martti Kaasalainen ◽  
Jef K. De Brabander ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Silicon Nanoparticles ◽  
Porous Silicon Nanoparticles ◽  
Influenza A Virus Infection

scholarly journals Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo

2019 ◽  
Vol 50 (1) ◽  
Author(s):  
Guihong Yang ◽  
Huipeng Huang ◽  
Mengyao Tang ◽  
Zifeng Cai ◽  
Cuiqin Huang ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
A549 Cells ◽  
Virus Challenge ◽  
Neuromedin B ◽  
Influenza A Virus Infection

Abstract The peptide neuromedin B (NMB) and its receptor (NMBR) represent a system (NMB/NMBR) of neuromodulation. Here, it was demonstrated that the expression of NMBR in cells or murine lung tissues was clearly upregulated in response to H1N1/PR8 influenza A virus infection. Furthermore, the in vitro and in vivo activities of NMB/NMBR during PR8 infection were investigated. It was observed that A549 cells lacking endogenous NMBR were more susceptible to virus infection than control cells, as evidenced by the increased virus production in the cells. Interestingly, a significant decrease in IFN-α and increased IL-6 expression were observed in these cells. The role of this system in innate immunity against PR8 infection was probed by treating mice with NMB. The NMB-treated mice were less susceptible to virus challenge, as evidenced by increased survival, increased body weight, and decreased viral NP expression compared with the control animals. Additionally, the results showed that exogenous NMB not only enhanced IFN-α expression but also appeared to inhibit the expression of NP and IL-6 in PR8-infected cells and animals. As expected, opposing effects were observed in the NMBR antagonist-treated cells and mice, which further confirmed the effects of NMB. Together, these data suggest that NMB/NMBR may be an important component of the host defence against influenza A virus infection. Thus, these proteins may serve as promising candidates for the development of novel antiviral drugs.

Influenza A Virus Infection of Human Schwann Cells In Vitro

2003 ◽  
Vol 123 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Joshua Levine ◽  
Craig A. Buchman ◽  
Nevis Fregien
Keyword(s):  
Virus Infection ◽  
Schwann Cells ◽  
Influenza A Virus ◽  
Influenza A ◽  
Influenza A Virus Infection

scholarly journals L-Ficolin Binds to the Glycoproteins Hemagglutinin and Neuraminidase and Inhibits Influenza A Virus Infection Both in vitro and in vivo

2012 ◽  
Vol 4 (3) ◽  
pp. 312-324 ◽  
Author(s):  
Qin Pan ◽  
Haidan Chen ◽  
Feng Wang ◽  
Victor Tunje Jeza ◽  
Wei Hou ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Influenza A Virus Infection

In vitro immunomodulatory activity of celastrol against influenza A virus infection

2018 ◽  
Vol 40 (3) ◽  
pp. 250-255 ◽  
Author(s):  
Niloofar Khalili ◽  
Ali Karimi ◽  
Mohammad-Taghi Moradi ◽  
Hedayatollah Shirzad
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Immunomodulatory Activity ◽  
Influenza A Virus Infection

scholarly journals 3-Anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection

2016 ◽  
Vol 7 (11) ◽  
pp. 839-843 ◽  
Author(s):  
Song Wang ◽  
Xiaoqin Luo ◽  
Ruoxiang Yan ◽  
Quanxin Wang ◽  
Qiuyue Qi ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
In Vivo Efficacy ◽  
Influenza A Virus Infection

scholarly journals In Vitro Inhibition of Human Influenza A Virus Infection by Fruit-Juice Concentrate of Japanese Plum (Prunus mume SIEB. et ZUCC)

2008 ◽  
Vol 31 (3) ◽  
pp. 511-515 ◽  
Author(s):  
Sangchai Yingsakmongkon ◽  
Daisei Miyamoto ◽  
Nongluk Sriwilaijaroen ◽  
Kimie Fujita ◽  
Kosai Matsumoto ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Fruit Juice ◽  
Prunus Mume ◽  
Human Influenza ◽  
Juice Concentrate ◽  
Influenza A Virus Infection ◽  
In Vitro Inhibition

scholarly journals Inhibition of Influenza A Virus Infection In Vitro by Peptides Designed In Silico

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e76876 ◽  
Author(s):  
Rogelio López-Martínez ◽  
G. Lizbeth Ramírez-Salinas ◽  
José Correa-Basurto ◽  
Blanca L. Barrón
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
In Silico ◽  
Influenza A ◽  
Influenza A Virus Infection
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