Successful suppression of a field mosquito population by sustained release of engineered male mosquitoes

2012 ◽  
Vol 30 (9) ◽  
pp. 828-830 ◽  
Author(s):  
Angela F Harris ◽  
Andrew R McKemey ◽  
Derric Nimmo ◽  
Zoe Curtis ◽  
Isaac Black ◽  
...  
Keyword(s):  
Sustained Release ◽  
Mosquito Population ◽  
Male Mosquitoes

scholarly journals Suppression of a Field Population of Aedes aegypti in Brazil by Sustained Release of Transgenic Male Mosquitoes

2015 ◽  
Vol 9 (7) ◽  
pp. e0003864 ◽  
Author(s):  
Danilo O. Carvalho ◽  
Andrew R. McKemey ◽  
Luiza Garziera ◽  
Renaud Lacroix ◽  
Christl A. Donnelly ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Sustained Release ◽  
Field Population ◽  
Male Mosquitoes ◽  
Transgenic Male

MATHEMATICAL MODELING OF THE IMPACT OF PERIODIC RELEASE OF STERILE MALE MOSQUITOES AND SEASONALITY ON THE POPULATION ABUNDANCE OF MALARIA MOSQUITOES

2020 ◽  
Vol 28 (02) ◽  
pp. 277-310 ◽  
Author(s):  
ENAHORO A. IBOI ◽  
ABBA B. GUMEL ◽  
JESSE E. TAYLOR
Keyword(s):  
Seasonal Variation ◽  
Mosquito Population ◽  
Local Temperature ◽  
Effective Control ◽  
Population Abundance ◽  
Sterile Male ◽  
Density Dependent ◽  
Malaria Mosquitoes ◽  
The Impact ◽  
Male Mosquitoes

This study presents a new mathematical model for assessing the impact of sterile insect technology (SIT) and seasonal variation in local temperature on the population abundance of malaria mosquitoes in an endemic setting. Simulations of the model, using temperature data from Kipsamoite area of Kenya, show that a peak abundance of the mosquito population is attained in the Kipsamoite area when the mean monthly temperature reaches [Formula: see text]. Furthermore, in the absence of seasonal variation in local temperature, our results show that releasing more sterile male mosquitoes (e.g., 100,000) over a one year period with relatively short duration between releases (e.g., weekly, bi-weekly or even monthly) is more effective than releasing smaller numbers of the sterile male mosquitoes (e.g., 10,000) over the same implementation period and frequency of release. It is also shown that density-dependent larval mortality plays an important role in determining the threshold number of sterile male mosquitoes that need to be released in order to achieve effective control (or elimination) of the mosquito population in the community. In particular, low(high) density-dependent mortality requires high(low) numbers of sterile male mosquitoes to be released to achieve such control. In the presence of seasonal variation in local temperature, effective control of the mosquito population using SIT is only feasible if a large number of the sterile male mosquitoes (e.g., 100,000) is periodically released within a very short time interval (at most weekly). In other words, seasonal variation in temperature necessitates more frequent releases (of a large number) of sterile male mosquitoes to ensure the effectiveness of the SIT intervention in curtailing the targeted mosquito population.

scholarly journals Successful suppression of a field population of Ae. aegypti mosquitoes using a novel biological vector control strategy is associated with significantly lower incidence of dengue

2019 ◽  
Author(s):  
Lisiane C Poncio ◽  
Filipe A dos Anjos ◽  
Deborah A de Oliveira ◽  
Débora Rebechi ◽  
Rodrigo N de Oliveira ◽  
...  
Keyword(s):  
Vector Control ◽  
Lower Incidence ◽  
Large Scale ◽  
Control Area ◽  
Environmentally Benign ◽  
Mosquito Population ◽  
Mosquito Vector ◽  
Sterile Male ◽  
Treated Area ◽  
Male Mosquitoes

AbstractBackgroundDespite extensive efforts to prevent recurrent Aedes-borne arbovirus epidemics, there is a steady rise in their global incidence. Vaccines/treatments show very limited efficacy and together with the emergence of mosquito resistance to insecticides, it has become urgent to develop alternative solutions for efficient, sustainable and environmentally benign mosquito vector control. Here we present a new Sterile Insect Technology (SIT)-based program that uses large-scale releases of sterile male mosquitoes produced by a highly effective, safe and environmentally benign method.Methods and findingsTo test the efficacy of this approach, a field trial was conducted in a Brazilian city (Jacarezinho), which presented a history of 3 epidemics of dengue in the past decade. Sterile male mosquitoes were produced from a locally acquired Aedes aegypti colony, and releases were carried out on a weekly basis for seven months in a predefined area. This treated area was matched to a control area, in terms of size, layout, historic mosquito infestation index, socioeconomic patterns and comparable prevalence of dengue cases in past outbreaks. Releases of sterile male mosquitoes resulted in up to 91.4% reduction of live progeny of field Ae. aegypti mosquitoes recorded over time. The reduction in the mosquito population was corroborated by the standard monitoring system (LIRAa index) as determined by the local municipality, which found that our treated neighborhoods were almost free of Ae. aegypti mosquitoes after 5 months of release, whereas neighborhoods adjacent to the treated area and the control neighborhoods were highly infested. Importantly, when a dengue outbreak started in Jacarezinho in March 2019, the effective mosquito population suppression was shown to be associated with a far lower incidence of dengue in the treated area (16 cases corresponding to 264 cases per 100,000 inhabitants) almost 16 times lower than the dengue incidence in the control area (198 cases corresponding to 4,360 dengue cases per 100,000 inhabitants).ConclusionsOur data present the first demonstration that a SIT-based intervention has the potential to prevent the spread of dengue, opening exciting new opportunities for preventing mosquito-borne disease.

scholarly journals Modeling the Control of Zika Virus Vector Population Using the Sterile Insect Technology

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
William Atokolo ◽  
Godwin Mbah Christopher Ezike
Keyword(s):  
Equilibrium Point ◽  
Equilibrium Points ◽  
Mosquito Population ◽  
Sterile Male ◽  
Wild Female ◽  
Globally Asymptotically Stable ◽  
Offspring Number ◽  
Vector Population ◽  
Control Intervention ◽  
Male Mosquitoes

This work is aimed at formulating a mathematical model for the control of mosquito population using sterile insect technology (SIT). SIT is an environmental friendly method, which depends on the release of sterile male mosquitoes that compete with wild male mosquitoes and mate with wild female mosquitoes, which leads to the production of no offspring. The basic offspring number of the mosquitoes’ population was computed, after which we investigated the existence of two equilibrium points of the model. When the basic offspring number of the model M0, is less than or equal to 1, a mosquito extinction equilibrium point E2, which is often biologically unattainable, was shown to exits. On the other hand, if M0>1, we have the nonnegative equilibrium point E1 which is shown to be both locally and globally asymptotically stable whenever M0>1. Local sensitivity analysis was then performed to know the parameters that should be targeted by control intervention strategies and result shows that female mating probability to be with the sterile male mosquitoes ρS, mating rate of the sterile mosquito β2, and natural death rates of both aquatic and female mosquitoesμA+μF have greater impacts on the reduction and elimination of mosquitoes from a population. Simulation of the model shows that enough release of sterile male mosquitoes into the population of the wild mosquitoes controls the mosquito population and as such can reduce the spread of mosquito borne disease such as Zika.

1558: Local Injection of Sustained-Release Antiandrogen Formulation into a Target Prostatic Site: An Experimental Study

2007 ◽  
Vol 177 (4S) ◽  
pp. 515-515
Author(s):  
Nobuyuki Goya ◽  
Kotara Gotanda ◽  
Yasuko Tomizawa ◽  
Hiroshi Toma
Keyword(s):  
Experimental Study ◽  
Sustained Release ◽  
Local Injection
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