A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans

Nature ◽  
2002 ◽  
Vol 417 (6889) ◽  
pp. 660-663 ◽  
Author(s):  
Sarah L. Crittenden ◽  
David S. Bernstein ◽  
Jennifer L. Bachorik ◽  
Beth E. Thompson ◽  
Maria Gallegos ◽  
...  
Keyword(s):  
Stem Cells ◽  
Caenorhabditis Elegans ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Germline Stem Cells

scholarly journals Uncovering the RNA-binding protein landscape in the pluripotency network of human embryonic stem cells

Cell Reports ◽  
2021 ◽  
Vol 35 (9) ◽  
pp. 109198
Author(s):  
Shlomi Dvir ◽  
Amir Argoetti ◽  
Chen Lesnik ◽  
Mark Roytblat ◽  
Kohava Shriki ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Embryonic Stem

Function of RNA-binding protein Musashi-1 in stem cells

2005 ◽  
Vol 306 (2) ◽  
pp. 349-356 ◽  
Author(s):  
Hideyuki Okano ◽  
Hironori Kawahara ◽  
Masako Toriya ◽  
Keio Nakao ◽  
Shinsuke Shibata ◽  
...  
Keyword(s):  
Stem Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

scholarly journals Regulation of the mitosis/meiosis decision in the Caenorhabditis elegans germline

2003 ◽  
Vol 358 (1436) ◽  
pp. 1359-1362 ◽  
Author(s):  
Sarah L. Crittenden ◽  
Christian R. Eckmann ◽  
Liaoteng Wang ◽  
David S. Bernstein ◽  
Marvin Wickens ◽  
...  
Keyword(s):  
Stem Cells ◽  
Caenorhabditis Elegans ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Germline Stem Cells ◽  
Puf Proteins ◽  
C Elegans ◽  
Transcriptional Regulatory ◽  
Mitotic Proliferation ◽  
Multicellular Organisms

During the development of multicellular organisms, the processes of growth and differentiation are kept in balance to generate and maintain tissues and organs of the correct size, shape and cellular composition. We have investigated the molecular controls of growth and differentiation in the Caenorhabditis elegans germline. A single somatic cell, called the distal tip cell, promotes mitotic proliferation in the adjacent germline by GLP–1/Notch signalling. Within the germline, the decisions between mitosis and meiosis and between spermatogenesis and oogenesis are controlled by a group of conserved RNA regulators. FBF, a member of the PUF (for Pumilio and FBF) family of RNA–binding proteins, promotes mitosis by repressing gld–1 mRNA activity; the GLD–1, GLD–2, GLD–3 and NOS–3 proteins promote entry into meiosis by regulating mRNAs that remain unknown. The regulatory balance between opposing FBF and GLD activities is crucial for controlling the extent of germline proliferation. PUF proteins regulate germline stem cells in both Drosophila and C. elegans and are localized to germline stem cells of the mammalian testis. Therefore, this post–transcriptional regulatory switch may be an ancient mechanism for controlling maintenance of stem cells versus differentiation.

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