DMY is a Y-specific DM-domain gene required for male development in the medaka fish

Nature ◽  
2002 ◽  
Vol 417 (6888) ◽  
pp. 559-563 ◽  
Author(s):  
Masaru Matsuda ◽  
Yoshitaka Nagahama ◽  
Ai Shinomiya ◽  
Tadashi Sato ◽  
Chika Matsuda ◽  
...  
Keyword(s):  
Medaka Fish ◽  
Male Development ◽  
Dm Domain

scholarly journals DMY gene induces male development in genetically female (XX) medaka fish

2007 ◽  
Vol 104 (10) ◽  
pp. 3865-3870 ◽  
Author(s):  
M. Matsuda ◽  
A. Shinomiya ◽  
M. Kinoshita ◽  
A. Suzuki ◽  
T. Kobayashi ◽  
...  
Keyword(s):  
Medaka Fish ◽  
Male Development

The sex determining gene of medaka: a Y-specific DM domain gene (DMY) is required for male development

2003 ◽  
Vol 28 (1-4) ◽  
pp. 135-139 ◽  
Author(s):  
Masaru Matsuda ◽  
Yoshitaka Nagahama ◽  
Tohru Kobayashi ◽  
Chika Matsuda ◽  
Satoshi Hamaguchi ◽  
...  
Keyword(s):  
Male Development ◽  
Dm Domain

scholarly journals Evolution of DMY, a Newly Emergent Male Sex-Determination Gene of Medaka Fish

Genetics ◽  
2004 ◽  
Vol 166 (4) ◽  
pp. 1887-1895
Author(s):  
Jianzhi Zhang
Keyword(s):  
Amino Acid ◽  
Sex Determination ◽  
Synonymous Substitution ◽  
Single Amino Acid ◽  
Medaka Fish ◽  
Single Amino Acid Change ◽  
Dm Domain ◽  
Determination System ◽  
Male Sex ◽  
Sex Determination System

Abstract The Japanese medaka fish Oryzias latipes has an XX/XY sex-determination system. The Y-linked sex-determination gene DMY is a duplicate of the autosomal gene DMRT1, which encodes a DM-domain-containing transcriptional factor. DMY appears to have originated recently within Oryzias, allowing a detailed evolutionary study of the initial steps that led to the new gene and new sex-determination system. Here I analyze the publicly available DMRT1 and DMY gene sequences of Oryzias species and report the following findings. First, the synonymous substitution rate in DMY is 1.73 times that in DMRT1, consistent with the male-driven evolution hypothesis. Second, the ratio of the rate of nonsynonymous nucleotide substitution (dN) to that of synonymous substitution (dS) is significantly higher in DMY than in DMRT1. Third, in DMRT1, the dN/dS ratio for the DM domain is lower than that for non-DM regions, as expected from the functional importance of the DM domain. But in DMY, the opposite is observed and the DM domain is likely under positive Darwinian selection. Fourth, only one characteristic amino acid distinguishes all DMY sequences from all DMRT1 sequences, suggesting that a single amino acid change may be largely responsible for the establishment of DMY as the male sex-determination gene in medaka fish.

Developmental and bone development indexes of medaka fish at 11 and 16 days of age

2018 ◽  
Vol 60 (4) ◽  
pp. 52-58 ◽  
Author(s):  
Thi Kieu Oanh Pham ◽  
Van Cuong Pham ◽  
Thi Thuy Lai ◽  
Duc Long Tran ◽  
Thanh Thuy To ◽  
...  
Keyword(s):  
Bone Development ◽  
Medaka Fish

Cytogenetics and sex determination in man and mammals

1970 ◽  
Vol 2 (S2) ◽  
pp. 7-30 ◽  
Author(s):  
C. E. Ford
Keyword(s):  
Y Chromosome ◽  
External Genitalia ◽  
Mutant Gene ◽  
Normal Female ◽  
Human Female ◽  
Present Evidence ◽  
Male Development ◽  
Sex Development ◽  
Internal Genitalia ◽  
Male External Genitalia

SummarySex in man and probably throughout the class mammalia is normally determined by the presence of a Y chromosome (male) or its absence (female). The presence of genetic loci on both the long and the short arm of the X chromosome in double dose appears to be essential for the development of mature functional ovaries in the human female though a single X suffices in the female mouse.The development of masculine genital anatomy and phenotype is a consequence of prior formation of testes. In the absence of gonads of either kind, female internal and external genitalia are formed but secondary sex development fails. In rare human families a mutant gene suppresses the development of male external genitalia in 46, XY embryos but permits the development of testes and male internal genitalia. The external phenotype is normal female (syndrome of testicular feminization). A sex-linked mutant gene in the mouse has a similar effect.The locus or loci directly concerned with male development might lie wholly on the Y chromosome or might be located on another chromosome or chromosomes. In the latter case it (or they) must be repressed in the female and normally activated by a locus or loci on the Y chromosome in the male. Present evidence does not permit the exclusion of either possibility.

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