Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation

Nature ◽  
2002 ◽  
Vol 417 (6887) ◽  
pp. 443-447 ◽  
Author(s):  
Christelle Forcet ◽  
Elke Stein ◽  
Laurent Pays ◽  
Véronique Corset ◽  
Fabien Llambi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Axon Outgrowth ◽  
Mapk Activation ◽  
Deleted In Colorectal Cancer

scholarly journals Presenilin-dependent “γ-Secretase” Processing of Deleted in Colorectal Cancer (DCC)

2003 ◽  
Vol 278 (33) ◽  
pp. 30425-30428 ◽  
Author(s):  
Yoshihito Taniguchi ◽  
Seong-Hun Kim ◽  
Sangram S. Sisodia
Keyword(s):  
Colorectal Cancer ◽  
Deleted In Colorectal Cancer

scholarly journals The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence

2019 ◽  
Vol 25 (2) ◽  
pp. 297-307 ◽  
Author(s):  
Daniel E. Vosberg ◽  
Marco Leyton ◽  
Cecilia Flores
Keyword(s):  
Colorectal Cancer ◽  
Substance Use ◽  
Nervous System ◽  
Axon Guidance ◽  
Psychiatric Disorders ◽  
Genetic Variants ◽  
Guidance System ◽  
Laboratory Animals ◽  
Compelling Evidence ◽  
Deleted In Colorectal Cancer

Abstract Axon guidance molecules direct growing axons toward their targets, assembling the intricate wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC (deleted in colorectal cancer), has profound effects, in laboratory animals, on the adolescent expansion of mesocorticolimbic pathways, particularly dopamine. Now, a rapidly growing literature suggests that (1) these same alterations could occur in humans, and (2) genetic variants in Netrin-1 and DCC are associated with depression, schizophrenia, and substance use. Together, these findings provide compelling evidence that Netrin-1 and DCC influence mesocorticolimbic-related psychopathological states that emerge during adolescence.

1035 DCC (Deleted in colorectal cancer) encodes a netrin receptor

1997 ◽  
Vol 28 ◽  
pp. S128
Author(s):  
Kazuko Keino-Masu ◽  
Masayuki Masu ◽  
Lindsay Hinck ◽  
E.David Leonardo ◽  
Esther T. Stoeckli ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Deleted In Colorectal Cancer
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