Addendum: Immune clearance of highly pathogenic SIV infection

Nature ◽  
2017 ◽  
Vol 547 (7661) ◽  
pp. 123-124 ◽  
Author(s):  
Scott G. Hansen ◽  
Michael Piatak ◽  
Abigail B. Ventura ◽  
Colette M. Hughes ◽  
Roxanne M. Gilbride ◽  
...  
Keyword(s):  
Highly Pathogenic ◽  
Immune Clearance ◽  
Siv Infection

scholarly journals Erratum: Corrigendum: Immune clearance of highly pathogenic SIV infection

Nature ◽  
2014 ◽  
Vol 514 (7524) ◽  
pp. 654-654 ◽  
Author(s):  
Scott G. Hansen ◽  
Michael Piatak ◽  
Abigail B. Ventura ◽  
Colette M. Hughes ◽  
Roxanne M. Gilbride ◽  
...  
Keyword(s):  
Highly Pathogenic ◽  
Immune Clearance ◽  
Siv Infection

scholarly journals Immune clearance of highly pathogenic SIV infection

Nature ◽  
2013 ◽  
Vol 502 (7469) ◽  
pp. 100-104 ◽  
Author(s):  
Scott G. Hansen ◽  
Michael Piatak Jr ◽  
Abigail B. Ventura ◽  
Colette M. Hughes ◽  
Roxanne M. Gilbride ◽  
...  
Keyword(s):  
Highly Pathogenic ◽  
Immune Clearance ◽  
Siv Infection

scholarly journals A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge

2019 ◽  
Vol 11 (501) ◽  
pp. eaaw2607 ◽  
Author(s):  
Scott G. Hansen ◽  
Emily E. Marshall ◽  
Daniel Malouli ◽  
Abigail B. Ventura ◽  
Colette M. Hughes ◽  
...  
Keyword(s):  
Effector Memory ◽  
Gene Encoding ◽  
Highly Pathogenic ◽  
Aids Vaccine ◽  
Cell Responses ◽  
Immunodeficiency Virus ◽  
Siv Infection ◽  
Cellular Immune

Previous studies have established that strain 68-1–derived rhesus cytomegalovirus (RhCMV) vectors expressing simian immunodeficiency virus (SIV) proteins (RhCMV/SIV) are able to elicit and maintain cellular immune responses that provide protection against mucosal challenge of highly pathogenic SIV in rhesus monkeys (RMs). However, these efficacious RhCMV/SIV vectors were replication and spread competent and therefore have the potential to cause disease in immunocompromised subjects. To develop a safer CMV-based vaccine for clinical use, we attenuated 68-1 RhCMV/SIV vectors by deletion of the Rh110 gene encoding the pp71 tegument protein (ΔRh110), allowing for suppression of lytic gene expression. ΔRh110 RhCMV/SIV vectors are highly spread deficient in vivo (~1000-fold compared to the parent vector) yet are still able to superinfect RhCMV+ RMs and generate high-frequency effector-memory–biased T cell responses. Here, we demonstrate that ΔRh110 68-1 RhCMV/SIV–expressing homologous or heterologous SIV antigens are highly efficacious against intravaginal (IVag) SIVmac239 challenge, providing control and progressive clearance of SIV infection in 59% of vaccinated RMs. Moreover, among 12 ΔRh110 RhCMV/SIV–vaccinated RMs that controlled and progressively cleared an initial SIV challenge, 9 were able to stringently control a second SIV challenge ~3 years after last vaccination, demonstrating the durability of this vaccine. Thus, ΔRh110 RhCMV/SIV vectors have a safety and efficacy profile that warrants adaptation and clinical evaluation of corresponding HCMV vectors as a prophylactic HIV/AIDS vaccine.

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