scholarly journals DNA methylation on N6-adenine in mammalian embryonic stem cells

Nature ◽  
2016 ◽  
Vol 532 (7599) ◽  
pp. 329-333 ◽  
Author(s):  
Tao P. Wu ◽  
Tao Wang ◽  
Matthew G. Seetin ◽  
Yongquan Lai ◽  
Shijia Zhu ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem

scholarly journals DAXX safeguards pericentromeric heterochromatin formation in embryonic stem cells

2021 ◽  
Author(s):  
Antoine Canat ◽  
Adeline Veillet ◽  
Robert Illingworth ◽  
Emmanuelle Fabre ◽  
Pierre Therizols
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Dna Damage ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Pericentric Heterochromatin ◽  
Dna Demethylation ◽  
Pericentromeric Heterochromatin ◽  
Major Satellite ◽  
Heterochromatin Formation

AbstractDNA methylation is essential for heterochromatin formation and repression of DNA repeat transcription, both of which are essential for genome integrity. Loss of DNA methylation is associated with disease, including cancer, but is also required for development. Alternative pathways to maintain heterochromatin are thus needed to limit DNA damage accumulation. Here, we find that DAXX, an H3.3 chaperone, protects pericentromeric heterochromatin and is essential for embryonic stem cells (ESCs) maintenance in the ground-state of pluripotency. Upon DNA demethylation-mediated damage, DAXX relocalizes to pericentromeric regions, and recruits PML and SETDB1, thereby promoting heterochromatin formation. In the absence of DAXX, the 3D-architecture and physical properties of pericentric heterochromatin are disrupted, resulting in derepression of major satellite DNA. Using epigenome editing tools, we demonstrate that H3.3, and specifically H3.3K9 modification, directly contribute to maintaining pericentromeric chromatin conformation. Altogether, our data reveal that DAXX and H3.3 unite DNA damage response and heterochromatin maintenance in ESCs.

scholarly journals Corrigendum: p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity

2018 ◽  
Vol 32 (19-20) ◽  
pp. 1358-1358
Author(s):  
Ayala Tovy ◽  
Adam Spiro ◽  
Ryan McCarthy ◽  
Zohar Shipony ◽  
Yael Aylon ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Clonal Heterogeneity

scholarly journals Effects of a hypomagnetic field on DNA methylation during the differentiation of embryonic stem cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Soonbong Baek ◽  
Hwan Choi ◽  
Hanseul Park ◽  
Byunguk Cho ◽  
Siyoung Kim ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Hypomagnetic Field

scholarly journals Lead Exposure Disrupts Global DNA Methylation in Human Embryonic Stem Cells and Alters Their Neuronal Differentiation

2014 ◽  
Vol 139 (1) ◽  
pp. 142-161 ◽  
Author(s):  
Marie-Claude Senut ◽  
Arko Sen ◽  
Pablo Cingolani ◽  
Asra Shaik ◽  
Susan J. Land ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Neuronal Differentiation ◽  
Human Embryonic Stem Cells ◽  
Lead Exposure ◽  
Embryonic Stem ◽  
Global Dna Methylation

Heterogeneity and Randomness of DNA Methylation Patterns in Human Embryonic Stem Cells

2012 ◽  
Vol 31 (6) ◽  
pp. 893-907 ◽  
Author(s):  
Albert G. Tsai ◽  
Debbie M. Chen ◽  
Mayin Lin ◽  
John C. F. Hsieh ◽  
Cindy Y. Okitsu ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Methylation Patterns

scholarly journals Targeting of De Novo DNA Methylation Throughout the Oct-4 Gene Regulatory Region in Differentiating Embryonic Stem Cells

PLoS ONE ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. e9937 ◽  
Author(s):  
Rodoniki Athanasiadou ◽  
Dina de Sousa ◽  
Kevin Myant ◽  
Cara Merusi ◽  
Irina Stancheva ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
De Novo ◽  
Regulatory Region ◽  
Embryonic Stem ◽  
Gene Regulatory

scholarly journals Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver

2009 ◽  
Vol 19 (6) ◽  
pp. 1044-1056 ◽  
Author(s):  
A. L. Brunner ◽  
D. S. Johnson ◽  
S. W. Kim ◽  
A. Valouev ◽  
T. E. Reddy ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Fetal Liver ◽  
Embryonic Stem ◽  
Human Fetal Liver ◽  
Methylation Patterns

DNA methylation in mouse embryonic stem cells and development

2007 ◽  
Vol 331 (1) ◽  
pp. 31-55 ◽  
Author(s):  
Tom Latham ◽  
Nick Gilbert ◽  
Bernard Ramsahoye
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells
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