Decapentaplegic and growth control in the developing Drosophila wing

Nature ◽  
2015 ◽  
Vol 527 (7578) ◽  
pp. 375-378 ◽  
Author(s):  
Takuya Akiyama ◽  
Matthew C. Gibson
Keyword(s):  
Growth Control ◽  
Drosophila Wing

Quantitative EM of gap junction distribution in mutant drosophila wing discs

1983 ◽  
Vol 41 ◽  
pp. 720-721
Author(s):  
J.S. Ryerse
Keyword(s):  
Gap Junctions ◽  
Growth Control ◽  
Intercellular Junctions ◽  
Wing Disc ◽  
En Bloc ◽  
Metabolic Cooperation ◽  
Drosophila Wing ◽  
Adult Wing ◽  
Wing Discs ◽  
Wing Pouch

Gap junctions are intercellular junctions found in both vertebrates and invertebrates through which ions and small molecules can pass. Their distribution in tissues could be of critical importance for ionic coupling or metabolic cooperation between cells or for regulating the intracellular movement of growth control and pattern formation factors. Studies of the distribution of gap junctions in mutants which develop abnormally may shed light upon their role in normal development. I report here the distribution of gap junctions in the wing pouch of 3 Drosophila wing disc mutants, vg (vestigial) a cell death mutant, 1(2)gd (lethal giant disc) a pattern abnormality mutant and 1(2)gl (lethal giant larva) a neoplastic mutant and compare these with wildtype wing discs.The wing pouch (the anlagen of the adult wing blade) of a wild-type wing disc is shown in Fig. 1 and consists of columnar cells (Fig. 5) joined by gap junctions (Fig. 6). 14000x EMs of conventionally processed, UA en bloc stained, longitudinally sectioned wing pouches were enlarged to 45000x with a projector and tracings were made on which the lateral plasma membrane (LPM) and gap junctions were marked.

Nubbin encodes a POU-domain protein required for proximal-distal patterning in the Drosophila wing

Development ◽  
1995 ◽  
Vol 121 (2) ◽  
pp. 589-599 ◽  
Author(s):  
M. Ng ◽  
F.J. Diaz-Benjumea ◽  
S.M. Cohen
Keyword(s):  
Growth Control ◽  
Normal Growth ◽  
Control Center ◽  
Genetic Mosaics ◽  
Drosophila Wing ◽  
Pou Domain ◽  
Compartment Boundary ◽  
Wing Structures ◽  
Wing Imaginal Discs ◽  
Anterior Posterior

The nubbin gene is required for normal growth and patterning of the wing in Drosophila. We report here that nubbin encodes a member of the POU family of transcription factors. Regulatory mutants which selectively remove nubbin expression from wing imaginal discs lead to loss of wing structures. Although nubbin is expressed throughout the wing primordium, analysis of genetic mosaics suggests a localized requirement for nubbin activity in the wing hinge. These observations suggest the existence of a novel proximal-distal growth control center in the wing hinge, which is required in addition to the well characterized anterior-posterior and dorsal-ventral compartment boundary organizing centers.

Growth control in the Drosophila wing disk

2020 ◽  
Vol 12 (3) ◽  
pp. e1478 ◽  
Author(s):  
Jia Gou ◽  
Jay A. Stotsky ◽  
Hans G. Othmer
Keyword(s):  
Growth Control ◽  
Drosophila Wing ◽  
Wing Disk

scholarly journals Interplay between cell proliferation and recruitment controls the duration of growth and final size of the Drosophila wing

2021 ◽  
Author(s):  
Elizabeth Diaz-Torres ◽  
Luis Manuel Muñoz-Nava ◽  
Marcos Nahmad
Keyword(s):  
Cell Proliferation ◽  
Growth Control ◽  
Control Mechanisms ◽  
Final Size ◽  
Exponential Process ◽  
Drosophila Cell ◽  
Cell Recruitment ◽  
Drosophila Wing ◽  
Long Time ◽  
Cell Growth And Proliferation

How organs robustly attain a final size despite perturbations in cell growth and proliferation rates is a fundamental question in developmental biology. Since organ growth is an exponential process driven mainly by cell proliferation, even small variations in cell proliferation rates, when integrated over a relatively long time, will lead to large differences in size, unless intrinsic control mechanisms compensate for these variations. Here we use a mathematical model to consider the hypothesis that in the developing wing of Drosophila, cell recruitment, a process in which undifferentiated neighboring cells are incorporated into the wing primordium, determines the time in which growth is arrested in this system. Under this assumption, our model shows that perturbations in proliferation rates of wing-committed cells are compensated by an inversely proportional duration of growth. This mechanism ensures that the final size of the wing is robust in a range of cell proliferation rates. Furthermore, we predict that growth control is lost when fluctuations in cell proliferation affects both wing-committed and recruitable cells. Our model suggests that cell recruitment may act as a temporal controller of growth to buffer fluctuations in cell proliferation rates, offering a solution to a long-standing problem in the field.

scholarly journals Dpp from the anterior stripe of cells is crucial for the growth of the Drosophila wing disc

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Shinya Matsuda ◽  
Markus Affolter
Keyword(s):  
Null Allele ◽  
Growth Control ◽  
Wing Disc ◽  
The Other ◽  
Morphogen Gradient ◽  
Posterior Compartment ◽  
Time Points ◽  
Larval Stages ◽  
Drosophila Wing ◽  
Control Growth

The Dpp morphogen gradient derived from the anterior stripe of cells is thought to control growth and patterning of the Drosophila wing disc. However, the spatial-temporal requirement of dpp for growth and patterning remained largely unknown. Recently, two studies re-addressed this question. By generating a conditional null allele, one study proposed that the dpp stripe is critical for patterning but not for growth (Akiyama and Gibson, 2015). In contrast, using a membrane-anchored nanobody to trap Dpp, the other study proposed that Dpp dispersal from the stripe is required for patterning and also for medial wing disc growth, at least in the posterior compartment (Harmansa et al., 2015). Thus, growth control by the Dpp morphogen gradient remains under debate. Here, by removing dpp from the stripe at different time points, we show that the dpp stripe source is indeed required for wing disc growth, also during third instar larval stages.

Ultrastructural features of prognostic significance in human oral cancer

1992 ◽  
Vol 50 (1) ◽  
pp. 618-619
Author(s):  
Karvita B. Ahluwalia ◽  
Nidhi Sharma
Keyword(s):  
Oral Cancer ◽  
Squamous Cell ◽  
Common Knowledge ◽  
Prognostic Significance ◽  
Growth Control ◽  
Terminal Differentiation ◽  
Squamous Cell Carcinomas ◽  
Effective Therapy ◽  
Invasive Potential ◽  
Biological Behaviour

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.

Microstructural investigation of surface roughness in MBE-grown AlAs

1995 ◽  
Vol 53 ◽  
pp. 454-455
Author(s):  
R. Rajesh ◽  
R. Droopad ◽  
C. H. Kuo ◽  
R. W. Carpenter ◽  
G. N. Maracas
Keyword(s):  
Thin Film ◽  
Real Time ◽  
Growth Control ◽  
Native Oxide ◽  
Effusion Cell ◽  
Surface Oxide Layer ◽  
Microstructural Investigation ◽  
Mbe Growth ◽  
Film Substrate ◽  
And Control

Knowledge of material pseudodielectric functions at MBE growth temperatures is essential for achieving in-situ, real time growth control. This allows us to accurately monitor and control thicknesses of the layers during growth. Undesired effusion cell temperature fluctuations during growth can thus be compensated for in real-time by spectroscopic ellipsometry. The accuracy in determining pseudodielectric functions is increased if one does not require applying a structure model to correct for the presence of an unknown surface layer such as a native oxide. Performing these measurements in an MBE reactor on as-grown material gives us this advantage. Thus, a simple three phase model (vacuum/thin film/substrate) can be used to obtain thin film data without uncertainties arising from a surface oxide layer of unknown composition and temperature dependence.In this study, we obtain the pseudodielectric functions of MBE-grown AlAs from growth temperature (650°C) to room temperature (30°C). The profile of the wavelength-dependent function from the ellipsometry data indicated a rough surface after growth of 0.5 μm of AlAs at a substrate temperature of 600°C, which is typical for MBE-growth of GaAs.

Smart Plant Growth Control and Monitoring System for Indoor Hydroponic Farming

2019 ◽  
Vol 1 (2) ◽  
Author(s):  
Fina Supegina
Keyword(s):  
Water Level ◽  
Monitoring System ◽  
Growth Control ◽  
Set Point ◽  
Water Solvent ◽  
Growth Room ◽  
Smart Control ◽  
Level Sensor ◽  
Planting Method ◽  
Hydroponic Growth

Hydroponics is one of planting method that use water as a medium of plants growth, in this technique, mineral solution added into the water solvent, allowing the nutrient uptake process by the plants.  Farming by hydroponic method must pay attention to the following parameters namely, temperature, humidity, the level of water needs and nutrients and also the level of sunlight need for photosynthesis process.  This research used hydroponic technique in hydroponic growth room, and  there is a LED growth light as an alternate of sunlight, due to this room is closed without sunlight.  There are outputs displayed in monitoring system namely, temperature sensor, humidity sensor, ultrasound sensor to detect height of the plant and water level sensor to measured height of the water as a medium of the plant.  Results of measured sensor in hydroponic growth room explained as the following:  fan cooler worked when temperature , and humidity  .  Water pump worked when water level is less than 50% accordance set point.  Control on LED Growth Light and LED Bulb when LDR sensor reached set point > 500 in bright condition, and < 500 in dark condition respectively. The average of Time update/received data in thing speak web is 2.4 second. Keywords: Smart Control, Hydroponic, IoT, Monitoring

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