scholarly journals PVT1 dependence in cancer with MYC copy-number increase

Nature ◽  
2014 ◽  
Vol 512 (7512) ◽  
pp. 82-86 ◽  
Author(s):  
Yuen-Yi Tseng ◽  
Branden S. Moriarity ◽  
Wuming Gong ◽  
Ryutaro Akiyama ◽  
Ashutosh Tiwari ◽  
...  
Keyword(s):  
Copy Number ◽  
Number Increase ◽  
Copy Number Increase

Alternative pathways of MYCN gene copy number increase in primary neuroblastoma tumors

2004 ◽  
Vol 153 (1) ◽  
pp. 10-15 ◽  
Author(s):  
Alexander Valent ◽  
Marine Guillaud-Bataille ◽  
Chantal Farra ◽  
François Lozach ◽  
Barbara Spengler ◽  
...  
Keyword(s):  
Copy Number ◽  
Gene Copy Number ◽  
Gene Copy ◽  
Alternative Pathways ◽  
Mycn Gene ◽  
Number Increase ◽  
Copy Number Increase

DNA sequence copy number increase at 8q: A potential new prognostic marker in high-grade osteosarcoma

1999 ◽  
Vol 84 (2) ◽  
pp. 114-121 ◽  
Author(s):  
Maija Tarkkanen ◽  
Inkeri Elomaa ◽  
Carl Blomqvist ◽  
Aarne H. Kivioja ◽  
Pirkko Kellokumpu-Lehtinen ◽  
...  
Keyword(s):  
Prognostic Marker ◽  
Dna Sequence ◽  
Copy Number ◽  
High Grade ◽  
Number Increase ◽  
High Grade Osteosarcoma ◽  
Copy Number Increase

scholarly journals Copy number increase of ACTN4 is a prognostic indicator in salivary gland carcinoma

2014 ◽  
Vol 3 (3) ◽  
pp. 613-622 ◽  
Author(s):  
Yukio Watabe ◽  
Taisuke Mori ◽  
Seiichi Yoshimoto ◽  
Takeshi Nomura ◽  
Takahiko Shibahara ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Copy Number ◽  
Prognostic Indicator ◽  
Salivary Gland Carcinoma ◽  
Number Increase ◽  
Gland Carcinoma ◽  
Copy Number Increase

19q13-ERCC1 Gene Copy Number Increase in Non–Small-Cell Lung Cancer

2013 ◽  
Vol 14 (5) ◽  
pp. 549-557 ◽  
Author(s):  
Elsa Vanhecke ◽  
Alexander Valent ◽  
Ximing Tang ◽  
Philippe Vielh ◽  
Luc Friboulet ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Copy Number ◽  
Gene Copy Number ◽  
Small Cell ◽  
Gene Copy ◽  
Small Cell Lung ◽  
Number Increase ◽  
Copy Number Increase

scholarly journals Mechanisms of Topoisomerase I (TOP1) Gene Copy Number Increase in a Stage III Colorectal Cancer Patient Cohort

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60613 ◽  
Author(s):  
David Hersi Smith ◽  
Ib Jarle Christensen ◽  
Niels Frank Jensen ◽  
Bo Markussen ◽  
Maria Unni Rømer ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patient ◽  
Copy Number ◽  
Topoisomerase I ◽  
Colorectal Cancer Patient ◽  
Gene Copy Number ◽  
Gene Copy ◽  
Patient Cohort ◽  
Number Increase ◽  
Copy Number Increase

Copy number variation of glyoxalase I

2014 ◽  
Vol 42 (2) ◽  
pp. 500-503 ◽  
Author(s):  
Alaa Shafie ◽  
Mingzhan Xue ◽  
Paul J. Thornalley ◽  
Naila Rabbani
Keyword(s):  
Copy Number Variation ◽  
Copy Number ◽  
Mouse Genome ◽  
Glyoxalase I ◽  
Number Increase ◽  
Number Variation ◽  
Tumour Cell Lines ◽  
Human Tumour Cell Lines ◽  
Human And Mouse ◽  
Copy Number Increase

The glyoxalase I gene GLO1 is a hotspot for copy number variation in the human and mouse genomes. The additional copies are often functional, giving rise to 2–4-fold increased glyoxalase I expression and activity. The prevalence of GLO1 copy number increase in the human population appears to be approximately 2% and may be linked to a risk of obesity, diabetes and aging. Increased GLO1 copy number has been found in human tumour cell lines and primary human tumours. The minimum common copy number increase region was approximately 1 Mb and it contained GLO1 and seven other genes. The increased copy number was generally functional, being associated with increased glyoxalase I protein and multidrug resistance in cancer chemotherapy. Glo1 duplication in the mouse genome is found within approximately 0.5 Mb of duplicated DNA. It was claimed to be linked to anxiety phenotypes, but other related discordant findings have doubted the association with glyoxalase I and further investigation is required.

FGFR1 copy number in breast cancer: associations with proliferation, histopathological grade and molecular subtypes

2021 ◽  
pp. jclinpath-2021-207456
Author(s):  
Anna M Bofin ◽  
Borgny Ytterhus ◽  
Elise Klæstad ◽  
Marit Valla
Keyword(s):  
Breast Cancer ◽  
Copy Number ◽  
Chromosome 8 ◽  
Axillary Lymph ◽  
Fluorescence In Situ Hybridisation ◽  
Axillary Lymph Node Metastases ◽  
Histopathological Grade ◽  
Luminal B ◽  
Number Increase ◽  
Copy Number Increase

AimsFGFR1 is located on 8p11.23 and regulates cell proliferation and survival. Increased copy number of FGFR1 is found in several cancers including cancer of the breast. ZNF703 is located close to FGFR1 at 8p11-12 and is frequently expressed in the luminal B subtype of breast cancer. Using tissue samples from a well-described cohort of patients with breast cancer with long-term follow-up, we studied associations between FGFR1 copy number in primary breast cancer tumours and axillary lymph node metastases, and proliferation status, molecular subtype and prognosis. Furthermore, we studied associations between copy number increase of FGFR1 and copy number of ZNF703.MethodsWe used fluorescence in situ hybridisation for FGFR1 and the chromosome 8 centromere applied to tissue microarray sections from a series of 534 breast cancer cases.ResultsWe found increased copy number (≥4) of FGFR1 in 74 (13.9%) of tumours. Only 6 of the 74 cases with increased copy number were non-luminal. Increased FGFR1 copy number was significantly associated with high Ki-67 status, high mitotic count and high histopathological grade, but not with prognosis. Forty-two (7.9%) cases had mean copy number ≥6. Thirty of these showed ZNF708 copy number ≥6.ConclusionsOur results show that FGFR1 copy number increase is largely found among luminal subtypes of breast cancer, particularly luminal B (HER2−). It is frequently accompanied by increased copy number of ZNF703. FGFR1 copy number increase is associated with high histopathological grade and high proliferation. However, we did not discover an association with prognosis.

Copy number increase of oncoprotein CIP2A is associated with poor patient survival in human head and neck squamous cell carcinoma

2015 ◽  
Vol 45 (5) ◽  
pp. 329-337 ◽  
Author(s):  
Johannes Routila ◽  
Türker Bilgen ◽  
Outi Saramäki ◽  
Reidar Grénman ◽  
Tapio Visakorpi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Copy Number ◽  
Patient Survival ◽  
Human Head ◽  
Poor Patient ◽  
Number Increase ◽  
Copy Number Increase ◽  
Poor Patient Survival
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