scholarly journals Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion

Nature ◽  
2013 ◽  
Vol 497 (7448) ◽  
pp. 263-267 ◽  
Author(s):  
Amelia E. Hochreiter-Hufford ◽  
Chang Sup Lee ◽  
Jason M. Kinchen ◽  
Jennifer D. Sokolowski ◽  
Sanja Arandjelovic ◽  
...  
Keyword(s):  
Myoblast Fusion ◽  
Apoptotic Cells ◽  
Phosphatidylserine Receptor

Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor

Blood ◽  
2004 ◽  
Vol 103 (9) ◽  
pp. 3362-3364 ◽  
Author(s):  
Yuya Kunisaki ◽  
Sadahiko Masuko ◽  
Mayuko Noda ◽  
Ayumi Inayoshi ◽  
Terukazu Sanui ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Apoptotic Cell ◽  
Fetal Liver ◽  
Lymphoid Cells ◽  
Cell Uptake ◽  
Developmental Defect ◽  
Apoptotic Cells ◽  
Phosphatidylserine Receptor ◽  
T Lymphopoiesis

Abstract Clearance of apoptotic cells by macrophages is considered important for prevention of inflammatory responses leading to tissue damage. The phosphatidylserine receptor (PSR), which specifically binds to phosphatidylserine (PS) exposed on the surface of apoptotic cells, mediates uptake of apoptotic cells in vitro, yet the physiologic relevance of PSR remains unknown. This issue was addressed by generating PSR-deficient (PSR-/-) mice. PSR-/- mice exhibited severe anemia and died during the perinatal period. In the PSR-/- fetal livers, erythroid differentiation was blocked at an early erythroblast stage. In addition, PSR-/- embryos exhibited thymus atrophy owing to a developmental defect of T-lymphoid cells. Clearance of apoptotic cells by macrophages was impaired in both liver and thymus of PSR-/- embryos. However, this did not induce up-regulation of inflammatory cytokines. These results indicate that during embryonic development, PSR-mediated apoptotic cell uptake is required for definitive erythropoiesis and T lymphopoiesis, independently of the prevention of inflammatory responses. (Blood. 2004;103:3362-3364)

scholarly journals The Presumptive Phosphatidylserine Receptor Is Dispensable for Innate Anti-inflammatory Recognition and Clearance of Apoptotic Cells

2005 ◽  
Vol 281 (9) ◽  
pp. 5718-5725 ◽  
Author(s):  
Justin E. Mitchell ◽  
Marija Cvetanovic ◽  
Nitu Tibrewal ◽  
Vimal Patel ◽  
Oscar R. Colamonici ◽  
...  
Keyword(s):  
Apoptotic Cells ◽  
Phosphatidylserine Receptor ◽  
Anti Inflammatory
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