scholarly journals NFIB is a governor of epithelial–melanocyte stem cell behaviour in a shared niche

Nature ◽  
2013 ◽  
Vol 495 (7439) ◽  
pp. 98-102 ◽  
Author(s):  
Chiung-Ying Chang ◽  
H. Amalia Pasolli ◽  
Eugenia G. Giannopoulou ◽  
Géraldine Guasch ◽  
Richard M. Gronostajski ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Behaviour ◽  
Melanocyte Stem Cell

Isolation and Characterization of Human Epidermal Stem Cells

1996 ◽  
Vol 91 (2) ◽  
pp. 141-146 ◽  
Author(s):  
P. H. Jones
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Matrix Proteins ◽  
Stem Cell Markers ◽  
Epidermal Stem Cells ◽  
Cell Behaviour ◽  
Isolation And Characterization ◽  
Integrin Family

1. The keratinocytes in human epidermis are constantly turned over and replaced by a population of stem cells located in the basal epidermal layer. Until recently there were no markers allowing the isolation of viable epidermal stem cells. However, it has now been shown that epidermal stem cells can be isolated both in vitro and direct from the epidermis as they express high levels of functional β1 integrin family receptors for extracellular matrix proteins. 2. The evidence for integrins as stem cell markers and the insights that have been gained into stem cell behaviour are reviewed.

scholarly journals Microenvironmental variables need to effect intrinsic phenotypic parameters of cancer stem cells to affect tumourigenicity

2013 ◽  
Author(s):  
Jacob G Scott ◽  
Prakash Chinnaiyan ◽  
Alexander ARA Anderson ◽  
Anita Hjelmeland ◽  
David Basanta
Keyword(s):  
Stem Cell ◽  
Therapeutic Strategy ◽  
Tissue Growth ◽  
Genetic Mutations ◽  
Phenotypic Traits ◽  
Cell Behaviour ◽  
New Information ◽  
Cancer Initiation ◽  
Cancer Types ◽  
Direct Feedback

Since the discovery of tumour initiating cells (TICs) in solid tumours, studies focussing on their role in cancer initiation and progression have abounded. The biological interrogation of these cells continues to yield volumes of information on their pro-tumourigenic behaviour, but actionable generalised conclusions have been scarce. Further, new information suggesting a dependence of tumour composition and growth on the microenvironment has yet to be studied theoretically. To address this point, we created a hybrid, discrete/continuous computational cellular automaton model of a generalised stem-cell driven tissue with a simple microenvironment. Using the model we explored the phenotypic traits inherent to the tumour initiating cells and the effect of the microenvironment on tissue growth. We identify the regions in phenotype parameter space where TICs are able to cause a disruption in homeostasis, leading to tissue overgrowth and tumour maintenance. As our parameters and model are non- specific, they could apply to any tissue TIC and do not assume specific genetic mutations. Targeting these phenotypic traits could represent a generalizable therapeutic strategy across cancer types. Further, we find that the microenvironmental variable does not strongly effect the outcomes, suggesting a need for direct feedback from the microenvironment onto stem-cell behaviour in future modelling endeavours.

Pax3 functions at a nodal point in melanocyte stem cell differentiation

Nature ◽  
2005 ◽  
Vol 433 (7028) ◽  
pp. 884-887 ◽  
Author(s):  
Deborah Lang ◽  
Min Min Lu ◽  
Li Huang ◽  
Kurt A. Engleka ◽  
Maozhen Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Nodal Point ◽  
Stem Cell Differentiation ◽  
Melanocyte Stem Cell

scholarly journals CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties

PLoS Genetics ◽  
2019 ◽  
Vol 15 (4) ◽  
pp. e1008034 ◽  
Author(s):  
Sandeep S. Joshi ◽  
Bishal Tandukar ◽  
Li Pan ◽  
Jennifer M. Huang ◽  
Ferenc Livak ◽  
...  
Keyword(s):  
Stem Cell ◽  
Melanocyte Stem Cell ◽  
Cell Subpopulations

scholarly journals Drosophila Rbp6 Is an Orthologue of Vertebrate Msi-1 and Msi-2, but Does Not Function Redundantly with dMsi to Regulate Germline Stem Cell Behaviour

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49810 ◽  
Author(s):  
Nicole A. Siddall ◽  
Marina Kalcina ◽  
Timothy M. Johanson ◽  
Adrian C. Monk ◽  
Franca Casagranda ◽  
...  
Keyword(s):  
Stem Cell ◽  
Germline Stem Cell ◽  
Cell Behaviour

Dominant role of the niche in melanocyte stem-cell fate determination

Nature ◽  
2002 ◽  
Vol 416 (6883) ◽  
pp. 854-860 ◽  
Author(s):  
Emi K. Nishimura ◽  
Siobhán A. Jordan ◽  
Hideo Oshima ◽  
Hisahiro Yoshida ◽  
Masatake Osawa ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Dominant Role ◽  
Cell Fate Determination ◽  
Stem Cell Fate ◽  
Fate Determination ◽  
Melanocyte Stem Cell

Topography, stem cell behaviour, and organogenesis

2004 ◽  
Vol 20 (10) ◽  
pp. 737-740 ◽  
Author(s):  
David Edgar ◽  
Simon Kenny ◽  
Sarah Almond ◽  
Patricia Murray
Keyword(s):  
Stem Cell ◽  
Cell Behaviour
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