scholarly journals DNase I sensitivity QTLs are a major determinant of human expression variation

Nature ◽  
2012 ◽  
Vol 482 (7385) ◽  
pp. 390-394 ◽  
Author(s):  
Jacob F. Degner ◽  
Athma A. Pai ◽  
Roger Pique-Regi ◽  
Jean-Baptiste Veyrieras ◽  
Daniel J. Gaffney ◽  
...  
Keyword(s):  
Dnase I ◽  
Major Determinant ◽  
Expression Variation ◽  
Dnase I Sensitivity

Serum stimulation of the c-fos enhancer induces reversible changes in c-fos chromatin structure

1990 ◽  
Vol 10 (3) ◽  
pp. 1126-1133
Author(s):  
J L Feng ◽  
B Villeponteau
Keyword(s):  
Growth Factors ◽  
Dna Sequences ◽  
Chromatin Structure ◽  
Transcriptional Activity ◽  
Dnase I ◽  
Enhancer Activity ◽  
Serum Stimulation ◽  
Fos Protein ◽  
Dnase I Sensitivity ◽  
Stimulation Of

Transcription of the proto-oncogene c-fos is known to be activated by growth factors in serum and subsequently repressed by the Fos protein. We show that generalized DNase I sensitivity of c-fos chromatin correlates closely with enhancer activity during induction, repression, and superinduction of the c-fos gene. Within 90 s of serum stimulation, proximal DNA sequences on both sides of the enhancer exhibit increased DNase I sensitivity. Within 5 min, elevated DNase I sensitivity spreads to chromatin at the distal 3' end of the c-fos gene. These results suggest that an open state of chromatin is propagated in both directions from the enhancer. The induced alterations in chromatin structure precede the increased transcriptional activity of the c-fos gene, suggesting that these changes in chromatin structure potentiate transcription.

DNASE I SENSITIVITY OF THE HUMAN MYBLOPEROXIDASE GENE IN DIFFERENTIATING MYRLOID TISSUE

1989 ◽  
Vol 11 (1) ◽  
pp. 117
Author(s):  
G. R. Antoun ◽  
K. F. Jorgenson ◽  
T. F. Zipf ◽  
J. van Rys
Keyword(s):  
Dnase I ◽  
Dnase I Sensitivity
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