Distinct stem cells contribute to mammary gland development and maintenance

Nature ◽  
2011 ◽  
Vol 479 (7372) ◽  
pp. 189-193 ◽  
Author(s):  
Alexandra Van Keymeulen ◽  
Ana Sofia Rocha ◽  
Marielle Ousset ◽  
Benjamin Beck ◽  
Gaëlle Bouvencourt ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mammary Gland ◽  
Mammary Gland Development ◽  
Gland Development

scholarly journals Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development

2019 ◽  
Vol 20 (9) ◽  
pp. 2357 ◽  
Author(s):  
Eunmi Lee ◽  
Raziye Piranlioglu ◽  
Max S. Wicha ◽  
Hasan Korkaya
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Mammary Gland ◽  
Mammary Gland Development ◽  
Mammary Epithelial ◽  
Stem Cell Markers ◽  
Quiescent State ◽  
Mammary Stem Cells ◽  
Mammary Stem ◽  
Gland Development

It is now widely believed that mammary epithelial cell plasticity, an important physiological process during the stages of mammary gland development, is exploited by the malignant cells for their successful disease progression. Normal mammary epithelial cells are heterogeneous and organized in hierarchical fashion, in which the mammary stem cells (MaSC) lie at the apex with regenerative capacity as well as plasticity. Despite the fact that the majority of studies supported the existence of multipotent MaSCs giving rise to both basal and luminal lineages, others proposed lineage restricted unipotent MaSCs. Consistent with the notion, the latest research has suggested that although normal MaSC subsets mainly stay in a quiescent state, they differ in their reconstituting ability, spatial localization, and molecular and epigenetic signatures in response to physiological stimuli within the respective microenvironment during the stages of mammary gland development. In this review, we will focus on current research on the biology of normal mammary stem cells with an emphasis on properties of cellular plasticity, self-renewal and quiescence, as well as the role of the microenvironment in regulating these processes. This will include a discussion of normal breast stem cell heterogeneity, stem cell markers, and lineage tracing studies.

scholarly journals Mammary gland development: cell fate specification, stem cells and the microenvironment

Development ◽  
2015 ◽  
Vol 142 (6) ◽  
pp. 1028-1042 ◽  
Author(s):  
J. L. Inman ◽  
C. Robertson ◽  
J. D. Mott ◽  
M. J. Bissell
Keyword(s):  
Stem Cells ◽  
Mammary Gland ◽  
Cell Fate ◽  
Mammary Gland Development ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Gland Development

Plasticity of mammary epithelia during normal development and neoplastic progression

1998 ◽  
Vol 76 (6) ◽  
pp. 997-1008 ◽  
Author(s):  
André Lochter
Keyword(s):  
Stem Cells ◽  
Mammary Gland ◽  
Epithelial Cells ◽  
Mammary Gland Development ◽  
Epithelial To Mesenchymal Transition ◽  
Branching Morphogenesis ◽  
Neoplastic Progression ◽  
Mesenchymal Transition ◽  
Mammary Epithelia ◽  
Gland Development

The functional unit of the mammary gland is the epithelium. It consists of luminal epithelial cells and myoepithelial cells that are generated from self-renewing stem and progenitor cells. The latter two cell types are scattered throughout the mammary epithelium and are concentrated in specialized structures, the end buds. In transplantation studies the pluripotency of mammary stem cells has been confirmed by demonstrating that they can regenerate a complete mammary gland. The ability of mammary epithelial cells to produce an elaborate ductal system during puberty and to differentiate into milk-producing alveoli during pregnancy is not only influenced by their genetic make-up, but is also governed by local molecular signals. Recent studies suggest that the transdifferentiation of epithelial cells into tumor cells is under microenvironmental control, despite the prominence of genetic mutations in breast cancer. Consequently, disturbances of tissue homeostasis can alter mammary gland development or result in preneoplastic and neoplastic pathologies. The plasticity of mammary epithelia is not limited to the entry of cells into differentiation and transdifferentiation pathways, but extends to their ability to regain facets of their preceding stage of functionality. Deciphering the molecular cues that determine cell plasticity is prerequisite for establishing a unifying concept of mammary gland development and breast tumor progression.Key words: branching morphogenesis, lactogenic differentiation, stem cells, epithelial-to-mesenchymal transition, cancer.

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