scholarly journals A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

Nature ◽  
2011 ◽  
Vol 472 (7341) ◽  
pp. 120-124 ◽  
Author(s):  
Kevin C. Wang ◽  
Yul W. Yang ◽  
Bo Liu ◽  
Amartya Sanyal ◽  
Ryan Corces-Zimmerman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Homeotic Gene ◽  
Active Chromatin ◽  
Homeotic Gene Expression

scholarly journals SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression

2017 ◽  
Vol 31 (8) ◽  
pp. 787-801 ◽  
Author(s):  
Kaixiang Cao ◽  
Clayton K. Collings ◽  
Stacy A. Marshall ◽  
Marc A. Morgan ◽  
Emily J. Rendleman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Homeotic Gene ◽  
Homeotic Gene Expression

Long noncoding RNA HOTTIP cooperates with CCCTC-binding factor to coordinate HOXA gene expression

2018 ◽  
Vol 500 (4) ◽  
pp. 852-859 ◽  
Author(s):  
Feng Wang ◽  
Zhongqiong Tang ◽  
Honglian Shao ◽  
Jun Guo ◽  
Tao Tan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Binding Factor ◽  
Hoxa Gene Expression ◽  
Hoxa Gene

scholarly journals Overexpression of Long Noncoding RNA HOTAIR Is a Unique Epigenetic Characteristic of Myxopapillary Ependymoma

2020 ◽  
Vol 79 (11) ◽  
pp. 1193-1202
Author(s):  
Haiyin Zheng ◽  
Katherina Baranova ◽  
Jun Song ◽  
Lei Yan ◽  
Saumik Biswas ◽  
...  
Keyword(s):  
Gene Expression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Hox Genes ◽  
Spinal Tumors ◽  
Myxopapillary Ependymoma ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Rna In Situ Hybridization ◽  
Lncrna Hotair

Abstract Ependymomas are a heterogeneous group of central nervous system tumors. Despite the recent advances, there are no specific biomarkers for ependymomas. In this study, we explored the role of homeobox (HOX) genes and long noncoding RNA (LncRNA) HOTAIR in ependymomas along the neural axis. Bioinformatics analysis was performed on publicly available gene expression data. Quantitative RT-PCR was used to determine the mRNA expression level among different groups of ependymomas. RNA in situ hybridization (ISH) with probes specific to HOTAIR was performed on tumor tissue microarray (TMA) constructed with 19 ependymomas formalin-fixed paraffin-embedded tissue. Gene expression analysis revealed higher expression of posterior HOX genes and HOTAIR in myxopapillary ependymoma (MPE), in comparison to other spinal and intracranial ependymoma. qRT-PCR confirmed the high HOXD10 expression in spinal MPEs. There was a significant upregulation of HOTAIR expression in spinal MPE and elevated HOTAIR expressions were further confirmed by RNA ISH on the TMA. Intriguingly, HOXD10 and HOTAIR expressions were not elevated in nonependymoma spinal tumors. Our collective results suggest an important role for the lncRNA HOTAIR and posterior HOX genes in the tumorigenesis of spinal MPE. HOTAIR may also serve as a potential diagnostic marker for spinal MPE.

Homeotic gene expression in the locustSchistocerca: An antibody that detects conserved epitopes in ultrabithorax and abdominal-A proteins

1994 ◽  
Vol 15 (1) ◽  
pp. 19-31 ◽  
Author(s):  
Robert Kelsh ◽  
Robert O. J. Weinzierl ◽  
Robert A. H. White ◽  
Michael Akam
Keyword(s):  
Gene Expression ◽  
Homeotic Gene ◽  
Homeotic Gene Expression
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