Progesterone induces adult mammary stem cell expansion

Nature ◽  
2010 ◽  
Vol 465 (7299) ◽  
pp. 803-807 ◽  
Author(s):  
Purna A. Joshi ◽  
Hartland W. Jackson ◽  
Alexander G. Beristain ◽  
Marco A. Di Grappa ◽  
Patricia A. Mote ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Expansion ◽  
Mammary Stem Cell ◽  
Stem Cell Expansion ◽  
Mammary Stem

scholarly journals NRF2/Long Noncoding RNA ROR Signaling Regulates Mammary Stem Cell Expansion and Protects against Estrogen Genotoxicity

2014 ◽  
Vol 289 (45) ◽  
pp. 31310-31318 ◽  
Author(s):  
Yongshu Zhang ◽  
Jixiang Xia ◽  
Qinglin Li ◽  
Yuan Yao ◽  
Gabriel Eades ◽  
...  
Keyword(s):  
Stem Cell ◽  
Long Noncoding Rna ◽  
Cell Expansion ◽  
Noncoding Rna ◽  
Mammary Stem Cell ◽  
Stem Cell Expansion ◽  
Mammary Stem

scholarly journals Author Correction: MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Cong Lv ◽  
Fengyin Li ◽  
Xiang Li ◽  
Yuhua Tian ◽  
Yue Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Wnt Signaling ◽  
Cell Expansion ◽  
Mammary Stem Cell ◽  
Breast Tumorigenesis ◽  
Stem Cell Expansion ◽  
Mammary Stem

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Abstract B023: Identifying molecular programs of progesterone-driven mammary stem cell expansion

2013 ◽  
Author(s):  
Yu-Jia Shiah ◽  
Purna A. Joshi ◽  
Alexander G. Beristain ◽  
Michelle Chan-Seng-Yue ◽  
Paul C. Boutros ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Expansion ◽  
Mammary Stem Cell ◽  
Stem Cell Expansion ◽  
Mammary Stem

scholarly journals The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage

Development ◽  
2015 ◽  
Vol 142 (5) ◽  
pp. 893-904 ◽  
Author(s):  
L. E. Lindley ◽  
K. M. Curtis ◽  
A. Sanchez-Mejias ◽  
M. E. Rieger ◽  
D. J. Robbins ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Expansion ◽  
Transcriptional Regulator ◽  
Mammary Stem Cell ◽  
Stem Cell Expansion ◽  
Mammary Stem

scholarly journals Regulating the regulator: Numb acts upstream of p53 to control mammary stem and progenitor cell

2015 ◽  
Vol 211 (4) ◽  
pp. 737-739 ◽  
Author(s):  
Marisa M. Faraldo ◽  
Marina A. Glukhova
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Fate ◽  
Cell Expansion ◽  
Progenitor Cell ◽  
Asymmetric Cell Divisions ◽  
Stem Cell Expansion ◽  
Cell Divisions ◽  
Cell Fate Determinant ◽  
Mammary Stem

In this issue, Tosoni et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201505037) report that cell fate determinant and tumor suppressor Numb imposes asymmetric cell divisions in mammary stem cells by regulating p53. Numb thereby restricts mammary stem cell expansion and controls the proliferation and lineage-specific characteristics of their progeny.

scholarly journals MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Cong Lv ◽  
Fengyin Li ◽  
Xiang Li ◽  
Yuhua Tian ◽  
Yue Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mammary Stem Cell ◽  
Mammary Epithelial ◽  
Breast Tumorigenesis ◽  
Stem Cell Expansion ◽  
Mammary Tumor Growth ◽  
Mammary Stem ◽  
Post Transcriptional Regulation ◽  
Multiple Signaling

Abstract MicroRNA-mediated post-transcriptional regulation plays key roles in stem cell self-renewal and tumorigenesis. However, the in vivo functions of specific microRNAs in controlling mammary stem cell (MaSC) activity and breast cancer formation remain poorly understood. Here we show that miR-31 is highly expressed in MaSC-enriched mammary basal cell population and in mammary tumors, and is regulated by NF-κB signaling. We demonstrate that miR-31 promotes mammary epithelial proliferation and MaSC expansion at the expense of differentiation in vivo. Loss of miR-31 compromises mammary tumor growth, reduces the number of cancer stem cells, as well as decreases tumor-initiating ability and metastasis to the lung, supporting its pro-oncogenic function. MiR-31 modulates multiple signaling pathways, including Prlr/Stat5, TGFβ and Wnt/β-catenin. Particularly, it activates Wnt/β-catenin signaling by directly targeting Wnt antagonists, including Dkk1. Importantly, Dkk1 overexpression partially rescues miR31-induced mammary defects. Together, these findings identify miR-31 as the key regulator of MaSC activity and breast tumorigenesis.

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