Vascular endothelial growth factor B controls endothelial fatty acid uptake

Nature ◽  
2010 ◽  
Vol 464 (7290) ◽  
pp. 917-921 ◽  
Author(s):  
Carolina E. Hagberg ◽  
Annelie Falkevall ◽  
Xun Wang ◽  
Erik Larsson ◽  
Jenni Huusko ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Fatty Acid ◽  
Growth Factor ◽  
Fatty Acid Uptake ◽  
Acid Uptake ◽  
Vascular Endothelial ◽  
Factor B ◽  
Endothelial Growth Factor

scholarly journals Endothelial Fatty Acid Transport: Role of Vascular Endothelial Growth Factor B

Physiology ◽  
2013 ◽  
Vol 28 (2) ◽  
pp. 125-134 ◽  
Author(s):  
Carolina Hagberg ◽  
Annika Mehlem ◽  
Annelie Falkevall ◽  
Lars Muhl ◽  
Ulf Eriksson
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Fatty Acid ◽  
Growth Factor ◽  
Vascular Endothelium ◽  
Dietary Lipids ◽  
Fatty Acid Transport ◽  
Vascular Endothelial ◽  
Factor B ◽  
Endothelial Growth Factor

Dietary lipids present in the circulation have to be transported through the vascular endothelium to be utilized by tissue cells, a vital mechanism that is still poorly understood. Vascular endothelial growth factor B (VEGF-B) regulates this process by controlling the expression of endothelial fatty acid transporter proteins (FATPs). Here, we summarize research on the role of the vascular endothelium in nutrient transport, with emphasis on VEGF-B signaling.

scholarly journals Class A1 scavenger receptor prevents obesity-associated blood pressure elevation through suppressing overproduction of vascular endothelial growth factor B in macrophages

2020 ◽  
Author(s):  
Xudong Zhu ◽  
Yan Wang ◽  
Liu Zhu ◽  
Ye Zhu ◽  
Kun Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Scavenger Receptor ◽  
Vascular Endothelial ◽  
Obese Mice ◽  
Blood Pressure Elevation ◽  
Perivascular Adipose Tissue ◽  
Factor B ◽  
Endothelial Growth Factor

Abstract Aims Dysfunctional innate immune function and inflammation contributes to the pathogenesis of obesity-associated hypertension, in which macrophage infiltration in the perivascular adipose tissue (PVAT) plays a key role. However, the mechanisms behind it are not well understood. Class A1 scavenger receptor (SR-A1) is one of the major pattern recognition receptors in modulating macrophage activity, and here, we aimed to investigate its role in obesity-associated hypertension. Methods and results Both diet-induced and genetic obesity were generated in mice. Deficiency in SR-A1 aggravated the obesity-induced blood pressure (BP) elevation and endothelial dysfunction in mice. The BP-elevating effect of SR-A1 deficiency was blocked by the down-regulation of vascular endothelial growth factor B (VEGF-B) in obese mice. Overexpression of VEGF-B raised BP in the obese mice but not in normal mice. Administration of fucoidan, a ligand of SR-A1, lowered BP, and VEGF-B levels in Sr-a1+/+ but not in Sr-a1−/− obese mice. Conclusion These results reveal a new link between PVAT and vascular biology in obesity orchestrated by the SR-A1/VEGF-B axis in macrophages. SR-A1 and VEGF-B may be promising therapeutic targets in the treatment of obesity-associated hypertension.

scholarly journals Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

1996 ◽  
Vol 93 (6) ◽  
pp. 2576-2581 ◽  
Author(s):  
B. Olofsson ◽  
K. Pajusola ◽  
A. Kaipainen ◽  
G. von Euler ◽  
V. Joukov ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Endothelial Cells ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Factor B ◽  
Endothelial Growth Factor

scholarly journals Differential Binding of Vascular Endothelial Growth Factor B Splice and Proteolytic Isoforms to Neuropilin-1

1999 ◽  
Vol 274 (30) ◽  
pp. 21217-21222 ◽  
Author(s):  
Taija Makinen ◽  
Birgitta Olofsson ◽  
Terhi Karpanen ◽  
Ulf Hellman ◽  
Shay Soker ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Factor B ◽  
Neuropilin 1 ◽  
Differential Binding ◽  
Endothelial Growth Factor
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