scholarly journals The Schistosoma japonicum genome reveals features of host–parasite interplay

Nature ◽  
2009 ◽  
Vol 460 (7253) ◽  
pp. 345-351 ◽  
Author(s):  
Keyword(s):  
Schistosoma Japonicum ◽  
Host Parasite ◽  
Japonicum Genome

Penetration and migration routes of Schistosoma japonicum miracidia in the snail Oncomelania hupensis

Parasitology ◽  
1991 ◽  
Vol 103 (1) ◽  
pp. 77-83 ◽  
Author(s):  
M. Y. Xia ◽  
J. Jourdane
Keyword(s):  
Spatial Distribution ◽  
Schistosoma Japonicum ◽  
Histological Study ◽  
Circulatory System ◽  
Selective Advantage ◽  
Oncomelania Hupensis ◽  
Migration Routes ◽  
Branchial Cavity ◽  
And Migration ◽  
Host Parasite

The routes of penetration and the strategies of invasion of Schistosoma japonicum miracidia in the snail vector Oncomelania hupensis were observed in a histological study. In all species of the genus Schistosoma, it is usually assumed that the miracidia achieve penetration through the tegument. Our results showed that at least 57% of S. japonicum miracidia penetrated the snail by natural openings (branchial cavity, mouth and rectum). Throughout the invasion phase, the larvae were observed in all the tissues and organs with the exception of the genital gland. The spatial distribution of parasites in the snail revealed that the migration towards the visceral organs such as the kidney, heart and sinuses (which are the most usual microhabitats of the mother sporocysts of S. japonicum) appeared to take place via the circulatory system. Using natural openings as routes for penetration probably provides a selective advantage in a host–parasite system in which the target mollusc is amphibious: we presume that the miracidia inside these natural openings are protected against desiccation when the snail leaves the water, and that they can subsequently invade the tissues.

Insight into the host–parasite interplay by proteomic study of host proteins copurified with the human parasite,Schistosoma japonicum

PROTEOMICS ◽  
2007 ◽  
Vol 7 (3) ◽  
pp. 450-462 ◽  
Author(s):  
Feng Liu ◽  
Wei Hu ◽  
Shu-Jian Cui ◽  
Ming Chi ◽  
Cai-Yun Fang ◽  
...  
Keyword(s):  
Schistosoma Japonicum ◽  
Host Proteins ◽  
Human Parasite ◽  
Proteomic Study ◽  
Host Parasite ◽  
Insight Into

scholarly journals New Perspectives on Host-Parasite Interplay by Comparative Transcriptomic and Proteomic Analyses of Schistosoma japonicum

2006 ◽  
Vol 2 (4) ◽  
pp. e29 ◽  
Author(s):  
Feng Liu ◽  
Jiong Lu ◽  
Wei Hu ◽  
Sheng-Yue Wang ◽  
Shu-Jian Cui ◽  
...  
Keyword(s):  
Schistosoma Japonicum ◽  
Proteomic Analyses ◽  
Host Parasite

Host–parasite relationships of Schistosoma japonicum in mammalian hosts

2001 ◽  
Vol 17 (7) ◽  
pp. 320-324 ◽  
Author(s):  
Yi-Xun He ◽  
Buz Salafsky ◽  
Kalyanasundaram Ramaswamy
Keyword(s):  
Schistosoma Japonicum ◽  
Host Parasite

The influence of sex and age on antibody isotype responses to Schistosoma mansoni and Schistosoma japonicum in human populations in Kenya and the Philippines

Parasitology ◽  
1997 ◽  
Vol 114 (4) ◽  
pp. 383-393 ◽  
Author(s):  
M. WEBSTER ◽  
B. D. L. LIBRANDA-RAMIREZ ◽  
G. D. ALIGUI ◽  
R. M. OLVEDA ◽  
J. H. OUMA ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Adult Worm ◽  
Schistosoma Japonicum ◽  
The Philippines ◽  
Human Populations ◽  
Human Antibody ◽  
Antibody Isotype ◽  
Host Parasite ◽  
Two Populations ◽  
Geographical Locations

We have investigated the effects of host age and sex on human antibody isotype responses to Schistosoma mansoni and Schistosoma japonicum adult worm (AW) and soluble egg (SEA) antigens, using sera from subjects in Kenya and the Philippines. Similar trends with age were observed between the two populations despite host, parasite and environmental differences between the two geographical locations. IgE to AW increased with age, whereas most isotype responses to SEA decreased with age. IgG1, IgG3 and IgG4 subclass responses to adult worm, however, did not show a broadly rising or falling pattern with age. Males were found to have higher IgG1, IgG4 and IgE to AW in both populations. This sex difference remained significant in the Kenyan population even after controlling statistically for confounding factors such as age and differences in intensity of infection. Analysis of S. mansoni and S. japonicum adult worm antigens reactive with IgE revealed a predominant 22 kDa band in both parasites. Only those individuals with relatively high IgE titres specifically reactive with S. mansoni or S. japonicum AW had detectable IgE against Sj22 or Sm22.

Studies on the Host Parasite Relationships to Schistosoma Japonicum: III

1959 ◽  
Vol 124 (6) ◽  
pp. 428-436 ◽  
Author(s):  
E. H. Sadun ◽  
B. C. Walton
Keyword(s):  
Schistosoma Japonicum ◽  
Host Parasite

scholarly journals Schistosoma japonicum cathepsin B2 (SjCB2) facilitates parasite invasion through the skin

2020 ◽  
Vol 14 (10) ◽  
pp. e0008810
Author(s):  
Bingkuan Zhu ◽  
Fang Luo ◽  
Yi Shen ◽  
Wenbin Yang ◽  
Chengsong Sun ◽  
...  
Keyword(s):  
Schistosoma Japonicum ◽  
Cysteine Protease ◽  
Immunoglobulin A ◽  
Hydrolytic Enzymes ◽  
Cysteine Protease Inhibitor ◽  
Complement C3 ◽  
Invasion Process ◽  
Complement Protein ◽  
Protein Components ◽  
Host Parasite

Cercariae invasion of the human skin is the first step in schistosome infection. Proteases play key roles in this process. However, little is known about the related hydrolytic enzymes in Schistosoma japonicum. Here, we investigated the biochemical features, tissue distribution and biological roles of a cathepsin B cysteine protease, SjCB2, in the invasion process of S. japonicum cercariae. Enzyme activity analysis revealed that recombinant SjCB2 is a typical cysteine protease with optimum temperature and pH for activity at 37°C and 4.0, respectively, and can be totally inhibited by the cysteine protease inhibitor E-64. Immunoblotting showed that both the zymogen (50 kDa) and mature enzyme (30.5 kDa) forms of SjCB2 are expressed in the cercariae. It was observed that SjCB2 localized predominantly in the acetabular glands and their ducts of cercariae, suggesting that the protease could be released during the invasion process. The protease degraded collagen, elastin, keratin, fibronectin, immunoglobulin (A, G and M) and complement C3, protein components of the dermis and immune system. In addition, proteomic analysis demonstrated that SjCB2 can degrade the human epidermis. Furthermore, it was showed that anti-rSjCB2 IgG significantly reduced (22.94%) the ability of the cercariae to invade the skin. The cysteine protease, SjCB2, located in the acetabular glands and their ducts of S. japonicum cercariae. We propose that SjCB2 facilitates skin invasion by degrading the major proteins of the epidermis and dermis. However, this cysteine protease may play additional roles in host-parasite interaction by degrading immunoglobins and complement protein.

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