scholarly journals Messenger RNA targeting to endoplasmic reticulum stress signalling sites

Nature ◽  
2008 ◽  
Vol 457 (7230) ◽  
pp. 736-740 ◽  
Author(s):  
Tomás Aragón ◽  
Eelco van Anken ◽  
David Pincus ◽  
Iana M. Serafimova ◽  
Alexei V. Korennykh ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Messenger Rna ◽  
Rna Targeting ◽  
Stress Signalling

scholarly journals Endoplasmic Reticulum Stress Is Involved in Baicalin Protection on Chondrocytes From Patients With Osteoarthritis

Dose-Response ◽  
2018 ◽  
Vol 16 (4) ◽  
pp. 155932581881063 ◽  
Author(s):  
Jiangang Cao ◽  
Yu Zhang ◽  
Tianyi Wang ◽  
Bo Li
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cell Viability ◽  
Er Stress ◽  
Messenger Rna ◽  
Cell Counting ◽  
Protective Effects ◽  
Gene Expressions ◽  
Protein Levels

Osteoarthritis (OA) affects elderly population worldwide and endoplasmic reticulum (ER) stress is known to be positively correlated with OA development. Previous reports prove the cytoprotective effects of baicalin on chondrocytes, whereas the mechanisms are hardly reported. Hence, we aimed to investigate the links between OA, ER stress, and baicalin. Chondrocytes from patients with OA were subjected to H2O2 treatment with or without baicalin pretreatment, and cell viability was assessed via Cell Counting Kit-8. Messenger RNA (mRNA) amounts of apoptosis-related genes (Bax, Bcl-2, and Caspase-3), extracellular matrix (ECM)-related genes (Collange I, Collange II, Aggrecan, and Sox9) and ER stress hallmarks (binding immunoglobulin protein [BiP] C/EBP homologous protein [CHOP]) were evaluated via quantitative real-time PCR. Bax, Bcl-2, BiP, and CHOP protein levels were analyzed via Western blot. Baicalin suppressed the changes in cell viability and apoptosis-related gene expressions caused by H2O2. Reactive oxygen species and glutathione/oxidized glutathione assay showed that H2O2 enhanced oxidative stress. Baicalin suppressed H2O2-induced downregulation of mRNA expression of ECM-related genes. Moreover, baicalin reduced H2O2-stimulated increase in oxidative stress and the expression of ER stress hallmarks. Endoplasmic reticulum stress inducer abolished the protective activities, whereas ER stress inhibitor did not exhibit extra protective effects. Baicalin pretreatment protected patient-derived chondrocytes from H2O2 through ER stress inhibition.

scholarly journals Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease

2018 ◽  
Vol 69 (4) ◽  
pp. 927-947 ◽  
Author(s):  
Cynthia Lebeaupin ◽  
Deborah Vallée ◽  
Younis Hazari ◽  
Claudio Hetz ◽  
Eric Chevet ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Liver Disease ◽  
Endoplasmic Reticulum Stress ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease ◽  
Stress Signalling

Endoplasmic Reticulum Stress Signalling During Development

2019 ◽  
pp. 17-47
Author(s):  
Caia S. Dominicus ◽  
Vruti Patel ◽  
Joseph E. Chambers ◽  
Elke Malzer ◽  
Stefan J. Marciniak
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Stress Signalling

Methotrexate prevents epidural fibrosis through endoplasmic reticulum stress signalling pathway

2017 ◽  
Vol 796 ◽  
pp. 131-138 ◽  
Author(s):  
Hui Chen ◽  
Lianqi Yan ◽  
Jingcheng Wang ◽  
Yu Sun ◽  
Xiaolei Li ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Signalling Pathway ◽  
Epidural Fibrosis ◽  
Stress Signalling
Sign in / Sign up

Export Citation Format

Share Document