Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

Nature ◽  
2007 ◽  
Vol 450 (7166) ◽  
pp. 110-114 ◽  
Author(s):  
Tobias Junt ◽  
E. Ashley Moseman ◽  
Matteo Iannacone ◽  
Steffen Massberg ◽  
Philipp A. Lang ◽  
...  
Keyword(s):  
B Cells ◽  
Lymph Nodes ◽  
Subcapsular Sinus

scholarly journals Single-Cell Transcriptional Heterogeneity of Lymphatic Endothelial Cells in Normal and Inflamed Murine Lymph Nodes

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1371
Author(s):  
Eliane Sibler ◽  
Yuliang He ◽  
Luca Ducoli ◽  
Nadja Keller ◽  
Noriki Fujimoto ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Lymph Nodes ◽  
Single Cell ◽  
In Silico Analysis ◽  
Skin Inflammation ◽  
Lymphatic Endothelial Cells ◽  
Depth Analysis ◽  
Subcapsular Sinus ◽  
Transcriptional Changes ◽  
Sinus Floor

The lymphatic system plays a crucial role in immunity and lymph nodes (LNs) undergo drastic remodeling during inflammation. Here, we used single-cell RNA sequencing to investigate transcriptional changes in lymphatic endothelial cells (LECs) in LNs draining naïve and inflamed skin. We found that subsets of LECs lining the different LN sinuses responded individually to skin inflammation, suggesting that they exert distinct functions under pathological conditions. Among the genes dysregulated during inflammation, we confirmed an up-regulation of CD200 in the LECs lining the subcapsular sinus floor with a possible function in immune regulation. Furthermore, by in silico analysis, we predicted numerous possible interactions of LECs with diverse immune cells in the LNs and found similarities in the transcriptional changes of LN LECs in different skin inflammation settings. In summary, we provide an in-depth analysis of the transcriptional landscape of LN LECs in the naïve state and in skin inflammation.

scholarly journals Disproportion in T-cell subpopulations in immunodeficient mutant hr/hr mice.

1979 ◽  
Vol 149 (1) ◽  
pp. 228-233 ◽  
Author(s):  
A B Reske-Kunz ◽  
M P Scheid ◽  
E A Boyse
Keyword(s):  
T Cells ◽  
T Cell ◽  
B Cells ◽  
Lymph Nodes ◽  
Salient Feature ◽  
Mutant Gene ◽  
Cell Subpopulations ◽  
T Cell Subpopulations

Mice of the HRS strain, which carry the mutant gene hr, were examined for abnormalities in representation of the three T-cell sets Ly1, Ly23, and Ly123 in the spleen. The salient feature of hr/hr mice, which are immunologically deficient, in comparison with +/hr segregants, was a gross disproportion in numbers of cells belonging to the Ly1 and Ly123 sets, at the age of 3--3.5 mo. At this age, Ly123 cells of hr/hr spleen outnumbered Ly1 cells by 2:1, whereas in +/hr spleens Ly123 cells were outnumbered by approximately 1:2. Cells from pooled lymph nodes of hr/hr mice did not show a correspondingly gross disporprotion of Ly1 and Ly123 cells. Total counts of splenic T cells, and of B cells, were not significantly different in hr/hr and +/hr mice.

Subcapsular Sinus Macrophages: The Seat of Innate and Adaptive Memory in Murine Lymph Nodes

2019 ◽  
Vol 40 (1) ◽  
pp. 35-48 ◽  
Author(s):  
Imogen Moran ◽  
Abigail K. Grootveld ◽  
Akira Nguyen ◽  
Tri Giang Phan
Keyword(s):  
Lymph Nodes ◽  
Adaptive Memory ◽  
Subcapsular Sinus

scholarly journals Hyperplasia of Mantle/Marginal Zone B Cells With Clear Cytoplasm in Peripheral Lymph Nodes

2001 ◽  
Vol 116 (4) ◽  
pp. 550-559 ◽  
Author(s):  
John P. Hunt ◽  
Joel A. Chan ◽  
Michael Samoszuk ◽  
Russell K. Brynes ◽  
Antonio M. Hernandez ◽  
...  
Keyword(s):  
B Cells ◽  
Lymph Nodes ◽  
Marginal Zone ◽  
Marginal Zone B Cells ◽  
Peripheral Lymph ◽  
Clear Cytoplasm

scholarly journals High CD99 expression in memory T and B cells in reactive lymph nodes

1999 ◽  
Vol 14 (6) ◽  
pp. 600 ◽  
Author(s):  
Cheol Keun Park ◽  
Young Kee Shin ◽  
Tae Jin Kim ◽  
Seong Hoe Park ◽  
Geung Hwan Ahn
Keyword(s):  
B Cells ◽  
Lymph Nodes ◽  
T And B Cells
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