Recognition of DNA damage by the Rad4 nucleotide excision repair protein

Nature ◽  
2007 ◽  
Vol 449 (7162) ◽  
pp. 570-575 ◽  
Author(s):  
Jung-Hyun Min ◽  
Nikola P. Pavletich
Keyword(s):  
Dna Damage ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Repair Protein ◽  
Nucleotide Excision ◽  
Nucleotide Excision Repair Protein

scholarly journals Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC

2008 ◽  
Vol 121 (17) ◽  
pp. 2850-2859 ◽  
Author(s):  
D. Hoogstraten ◽  
S. Bergink ◽  
J. M. Y. Ng ◽  
V. H. M. Verbiest ◽  
M. S. Luijsterburg ◽  
...  
Keyword(s):  
Dna Damage ◽  
Damage Detection ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Repair Protein ◽  
Nucleotide Excision ◽  
Nucleotide Excision Repair Protein

scholarly journals Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC

2008 ◽  
Vol 121 (17) ◽  
pp. 2972-2972
Author(s):  
D. Hoogstraten ◽  
S. Bergink ◽  
V. H. M. Verbiest ◽  
M. S. Luijsterburg ◽  
B. Geverts ◽  
...  
Keyword(s):  
Dna Damage ◽  
Damage Detection ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Repair Protein ◽  
Nucleotide Excision ◽  
Nucleotide Excision Repair Protein

scholarly journals Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC

2008 ◽  
Vol 121 (23) ◽  
pp. 3991-3991 ◽  
Author(s):  
D. Hoogstraten ◽  
S. Bergink ◽  
J. M. Y. Ng ◽  
V. H. M. Verbiest ◽  
M. S. Luijsterburg ◽  
...  
Keyword(s):  
Dna Damage ◽  
Damage Detection ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Repair Protein ◽  
Nucleotide Excision ◽  
Nucleotide Excision Repair Protein

scholarly journals Inactivation of XPF Sensitizes Cancer Cells to Gemcitabine

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Joseph W. George ◽  
Mika Bessho ◽  
Tadayoshi Bessho
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Dna Repair ◽  
Cancer Cells ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Repair Protein ◽  
Nucleotide Excision ◽  
Gemcitabine Treatment ◽  
Nucleotide Excision Repair Protein

Gemcitabine (2′, 2′-difluorodeoxycytidine; dFdC) is a deoxycytidine analog and is used primarily against pancreatic cancer. The cytotoxicity of gemcitabine is due to the inhibition of DNA replication. However, a mechanism of removal of the incorporated dFdC is largely unknown. In this report, we discovered that nucleotide excision repair protein XPF-ERCC1 participates in the repair of gemcitabine-induced DNA damage and inactivation of XPF sensitizes cells to gemcitabine. Further analysis identified that XPF-ERCC1 functions together with apurinic/apyrimidinic endonuclease (APE) in the repair of gemcitabine-induced DNA damage. Our results demonstrate the importance of the evaluation of DNA repair activities in gemcitabine treatment.

scholarly journals Structure of UvrA nucleotide excision repair protein in complex with modified DNA

2011 ◽  
Vol 18 (2) ◽  
pp. 191-197 ◽  
Author(s):  
Marcin Jaciuk ◽  
Elżbieta Nowak ◽  
Krzysztof Skowronek ◽  
Anna Tańska ◽  
Marcin Nowotny
Keyword(s):  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Repair Protein ◽  
Modified Dna ◽  
Nucleotide Excision ◽  
Nucleotide Excision Repair Protein
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