Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding

Nature ◽  
2007 ◽  
Vol 447 (7142) ◽  
pp. 316-320 ◽  
Author(s):  
Mayumi Ito ◽  
Zaixin Yang ◽  
Thomas Andl ◽  
Chunhua Cui ◽  
Noori Kim ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Adult Mouse ◽  
De Novo ◽  
Mouse Skin

scholarly journals Epidermal and hair follicle transglutaminases. Partial characterization of soluble enzymes in newborn mouse skin.

1988 ◽  
Vol 263 (9) ◽  
pp. 4236-4241 ◽  
Author(s):  
N Martinet ◽  
H C Kim ◽  
J E Girard ◽  
T P Nigra ◽  
D H Strong ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Mouse Skin ◽  
Partial Characterization ◽  
Newborn Mouse ◽  
Soluble Enzymes

The Nude Mouse Skin Phenotype: The Role of Foxn1 in Hair Follicle Development and Cycling

2001 ◽  
Vol 71 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Lars Mecklenburg ◽  
Motonobu Nakamura ◽  
John P. Sundberg ◽  
Ralf Paus
Keyword(s):  
Hair Follicle ◽  
Nude Mouse ◽  
Mouse Skin ◽  
Follicle Development ◽  
Hair Follicle Development

The fine structure of the melanocytes of the adult mouse hair follicle during their amelanotic phase (telogen and early anagen)

1977 ◽  
Vol 150 (4) ◽  
pp. 653-658 ◽  
Author(s):  
Alene F. Silver ◽  
Robert D. Fleischmann ◽  
Herman B. Chase
Keyword(s):  
Fine Structure ◽  
Hair Follicle ◽  
Adult Mouse

scholarly journals Runx1 Directly Promotes Proliferation of Hair Follicle Stem Cells and Epithelial Tumor Formation in Mouse Skin

2010 ◽  
Vol 30 (10) ◽  
pp. 2518-2536 ◽  
Author(s):  
Charlene S. L. Hoi ◽  
Song Eun Lee ◽  
Shu-Yang Lu ◽  
David J. McDermitt ◽  
Karen M. Osorio ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Kinase Inhibitor ◽  
Mouse Skin ◽  
Tumor Formation ◽  
Cancer Genes ◽  
Direct Role ◽  
Epithelial Tumor ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

ABSTRACT Runx1/AML1 is a transcription factor implicated in tissue stem cell regulation and belongs to the small Runx family of cancer genes. In the hair follicle (HF), Runx1 epithelial deletion in morphogenesis impairs normal adult hair homeostasis (cycle) and blocks adult hair follicle stem cells (HFSCs) in quiescence. Here, we show that these effects are overcome later in adulthood. By deleting Runx1 after the end of morphogenesis, we demonstrate its direct role in promoting anagen onset and HFSC proliferation. Runx1 deletion resulted in cyclin-dependent kinase inhibitor Cdkn1a (p21) upregulation. Interfering with Runx1 function in cultured HFSCs impaired their proliferation and normal G0/G1 and G1/S cell cycle progression. The proliferation defect could be rescued by Runx1 readdition or by p21 deletion. Chemically induced skin tumorigenesis in mice turned on broad Runx1 expression in regions of the skin epithelium, papillomas, and squamous cell carcinomas. In addition, it revealed reduced rates of tumor formation in the absence of Runx1 that were accompanied by decreased epithelial levels of phospho-Stat3. Runx1 protein expression was similar in normal human and mouse hair cycles. We propose that Runx1 may act as a skin oncogene by directly promoting proliferation of the epithelial cells.

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