scholarly journals Vaccination strategies for foot-and-mouth disease

Nature ◽  
2007 ◽  
Vol 445 (7128) ◽  
pp. E12-E12 ◽  
Author(s):  
Richard P. Kitching ◽  
Nicholas M. Taylor ◽  
Michael V. Thrusfield
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Vaccination Strategies ◽  
Foot And Mouth

scholarly journals Modelling vaccination strategies against foot-and-mouth disease

Nature ◽  
2002 ◽  
Vol 421 (6919) ◽  
pp. 136-142 ◽  
Author(s):  
M. J. Keeling ◽  
M. E. J. Woolhouse ◽  
R. M. May ◽  
G. Davies ◽  
B. T. Grenfell
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Vaccination Strategies ◽  
Foot And Mouth

Evaluating vaccination strategies to control foot-and-mouth disease: a model comparison study

2014 ◽  
Vol 143 (6) ◽  
pp. 1256-1275 ◽  
Author(s):  
S. E. ROCHE ◽  
M. G. GARNER ◽  
R. L. SANSON ◽  
C. COOK ◽  
C. BIRCH ◽  
...  
Keyword(s):  
Model Comparison ◽  
Control Strategies ◽  
Foot And Mouth Disease ◽  
Simulation Models ◽  
Control Programme ◽  
Mouth Disease ◽  
Considerable Uncertainty ◽  
Vaccination Strategies ◽  
Epidemic Size ◽  
Foot And Mouth

SUMMARYSimulation models can offer valuable insights into the effectiveness of different control strategies and act as important decision support tools when comparing and evaluating outbreak scenarios and control strategies. An international modelling study was performed to compare a range of vaccination strategies in the control of foot-and-mouth disease (FMD). Modelling groups from five countries (Australia, New Zealand, USA, UK, The Netherlands) participated in the study. Vaccination is increasingly being recognized as a potentially important tool in the control of FMD, although there is considerable uncertainty as to how and when it should be used. We sought to compare model outputs and assess the effectiveness of different vaccination strategies in the control of FMD. Using a standardized outbreak scenario based on data from an FMD exercise in the UK in 2010, the study showed general agreement between respective models in terms of the effectiveness of vaccination. Under the scenario assumptions, all models demonstrated that vaccination with ‘stamping-out’ of infected premises led to a significant reduction in predicted epidemic size and duration compared to the ‘stamping-out’ strategy alone. For all models there were advantages in vaccinating cattle-only rather than all species, using 3-km vaccination rings immediately around infected premises, and starting vaccination earlier in the control programme. This study has shown that certain vaccination strategies are robust even to substantial differences in model configurations. This result should increase end-user confidence in conclusions drawn from model outputs. These results can be used to support and develop effective policies for FMD control.

scholarly journals A Simulation Study of the Use of Vaccination to Control Foot-and-Mouth Disease Outbreaks Across Australia

2021 ◽  
Vol 8 ◽  
Author(s):  
Tim R. Capon ◽  
Michael G. Garner ◽  
Sorada Tapsuwan ◽  
Sharon Roche ◽  
Andrew C. Breed ◽  
...  
Keyword(s):  
Control Strategies ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
International Standards ◽  
Disease Spread ◽  
Diverse Range ◽  
Stakeholder Consultation ◽  
Vaccination Strategies ◽  
Spread Model ◽  
Foot And Mouth

This study examines the potential for foot-and-mouth disease (FMD) control strategies that incorporate vaccination to manage FMD spread for a range of incursion scenarios across Australia. Stakeholder consultation was used to formulate control strategies and incursion scenarios to ensure relevance to the diverse range of Australian livestock production regions and management systems. The Australian Animal Disease Spread model (AADIS) was used to compare nine control strategies for 13 incursion scenarios, including seven control strategies incorporating vaccination. The control strategies with vaccination differed in terms of their approaches for targeting areas and species. These strategies are compared with two benchmark strategies based on stamping out only. Outbreak size and duration were compared in terms of the total number of infected premises, the duration of the control stage of an FMD outbreak, and the number of vaccinated animals. The three key findings from this analysis are as follows: (1) smaller outbreaks can be effectively managed by stamping out without vaccination, (2) the size and duration of larger outbreaks can be significantly reduced when vaccination is used, and (3) different vaccination strategies produced similar reductions in the size and duration of an outbreak, but the number of animals vaccinated varied. Under current international standards for regaining FMD-free status, vaccinated animals need to be removed from the population at the end of the outbreak to minimize trade impacts. We have shown that selective, targeted vaccination strategies could achieve effective FMD control while significantly reducing the number of animals vaccinated.

scholarly journals Hand, Foot, and Mouth Disease in China: Critical Community Size and Spatial Vaccination Strategies

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Thomas P. Van Boeckel ◽  
Saki Takahashi ◽  
Qiaohong Liao ◽  
Weijia Xing ◽  
Shengjie Lai ◽  
...  
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Community Size ◽  
Vaccination Strategies ◽  
Foot And Mouth

scholarly journals Evaluating vaccination strategies to control foot-and-mouth disease: a country comparison study

2018 ◽  
Vol 146 (9) ◽  
pp. 1138-1150 ◽  
Author(s):  
T.G. Rawdon ◽  
M.G. Garner ◽  
R.L. Sanson ◽  
M.A. Stevenson ◽  
C. Cook ◽  
...  
Keyword(s):  
Relative Effectiveness ◽  
Foot And Mouth Disease ◽  
Simulation Models ◽  
Mouth Disease ◽  
Control Measures ◽  
Economic Implications ◽  
Outbreak Management ◽  
Vaccination Strategies ◽  
Fmd Virus ◽  
Foot And Mouth

AbstractVaccination is increasingly being recognised as a potential tool to supplement ‘stamping out’ for controlling foot-and-mouth disease (FMD) outbreaks in non-endemic countries. Infectious disease simulation models provide the opportunity to determine how vaccination might be used in the face of an FMD outbreak. Previously, consistent relative benefits of specific vaccination strategies across different FMD simulation modelling platforms have been demonstrated, using a UK FMD outbreak scenario. We extended this work to assess the relative effectiveness of selected vaccination strategies in five countries: Australia, New Zealand, the USA, the UK and Canada. A comparable, but not identical, FMD outbreak scenario was developed for each country with initial seeding of Pan Asia type O FMD virus into an area with a relatively high density of livestock farms. A series of vaccination strategies (in addition to stamping out (SO)) were selected to evaluate key areas of interest from a disease response perspective, including timing of vaccination, species considerations (e.g. vaccination of only those farms with cattle), risk area vaccination and resources available for vaccination. The study found that vaccination used with SO was effective in reducing epidemic size and duration in a severe outbreak situation. Early vaccination and unconstrained resources for vaccination consistently outperformed other strategies. Vaccination of only those farms with cattle produced comparable results, with some countries demonstrating that this could be as effective as all species vaccination. Restriction of vaccination to higher risk areas was less effective than other strategies. This study demonstrates consistency in the relative effectiveness of selected vaccination strategies under different outbreak start up conditions conditional on the assumption that each of the simulation models provide a realistic estimation of FMD virus spread. Preferred outbreak management approaches must however balance the principles identified in this study, working to clearly defined outbreak management objectives, while having a good understanding of logistic requirements and the socio-economic implications of different control measures.

Vaccination strategies for foot-and-mouth disease (reply)

Nature ◽  
2007 ◽  
Vol 445 (7128) ◽  
pp. E12-E13 ◽  
Author(s):  
Michael J. Tildesley ◽  
Nicholas J. Savill ◽  
Darren J. Shaw ◽  
Rob Deardon ◽  
Stephen P. Brooks ◽  
...  
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Vaccination Strategies ◽  
Foot And Mouth

scholarly journals Vaccination Strategies against Foot-and-Mouth Disease

2008 ◽  
Vol 12 (1) ◽  
pp. 27-35
Author(s):  
Toshiyuki TSUTSUI ◽  
Sota KOBAYASHI ◽  
Takehisa YAMAMOTO ◽  
Akiko NISHIGUCHI ◽  
Kenichi SAKAMOTO
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Vaccination Strategies ◽  
Foot And Mouth

Biophysical Measurement of Molecular Weight of Foot-and-Mouth Disease RNA Fragments

1974 ◽  
Vol 32 ◽  
pp. 262-263
Author(s):  
Sydney S. Breese ◽  
Howard L. Bachrach
Keyword(s):  
Chemical Properties ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Distilled Water ◽  
Bovine Plasma ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Carbon Coated ◽  
Rna Fragments ◽  
Physical And Chemical

Continuing studies on the physical and chemical properties of foot-and-mouth disease virus (FMDV) have included electron microscopy of RNA strands released when highly purified virus (1) was dialyzed against demlneralized distilled water. The RNA strands were dried on formvar-carbon coated electron microscope screens pretreated with 0.1% bovine plasma albumin in distilled water. At this low salt concentration the RNA strands were extended and were stained with 1% phosphotungstic acid. Random dispersions of strands were recorded on electron micrographs, enlarged to 30,000 or 40,000 X and the lengths measured with a map-measuring wheel. Figure 1 is a typical micrograph and Fig. 2 shows the distributions of strand lengths for the three major types of FMDV (A119 of 6/9/72; C3-Rezende of 1/5/73; and O1-Brugge of 8/24/73.

High resolution surface structure of foot-and-mouth disease virus

1978 ◽  
Vol 36 (2) ◽  
pp. 376-377
Author(s):  
S. S. Breese ◽  
H. L. Bachrach
Keyword(s):  
Electron Microscopy ◽  
High Resolution ◽  
Surface Structure ◽  
Disease Virus ◽  
Potassium Phosphate ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Physical Measurements ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Models for the structure of foot-and-mouth disease virus (FMDV) have been proposed from chemical and physical measurements (Brown, et al., 1970; Talbot and Brown, 1972; Strohmaier and Adam, 1976) and from rotational image-enhancement electron microscopy (Breese, et al., 1965). In this report we examine the surface structure of FMDV particles by high resolution electron microscopy and compare it with that of particles in which the outermost capsid protein VP3 (ca. 30, 000 daltons) has been split into smaller segments, two of which VP3a and VP3b have molecular weights of about 15, 000 daltons (Bachrach, et al., 1975).Highly purified and concentrated type A12, strain 119 FMDV (5 mg/ml) was prepared as previously described (Bachrach, et al., 1964) and stored at 4°C in 0. 2 M KC1-0. 5 M potassium phosphate buffer at pH 7. 5. For electron microscopy, 1. 0 ml samples of purified virus and trypsin-treated virus were dialyzed at 4°C against 0. 2 M NH4OAC at pH 7. 3, deposited onto carbonized formvar-coated copper screens and stained with phosphotungstic acid, pH 7. 3.

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