Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology

Nature ◽  
2006 ◽  
Vol 442 (7104) ◽  
pp. 814-817 ◽  
Author(s):  
Yong Kim ◽  
Jee Young Sung ◽  
Ilaria Ceglia ◽  
Ko-Woon Lee ◽  
Jung-Hyuck Ahn ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Actin Polymerization ◽  
Spine Morphology ◽  
Dendritic Spine Morphology

scholarly journals Splice variants of the CaV1.3 L-type calcium channel regulate dendritic spine morphology

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Ruslan Stanika ◽  
Marta Campiglio ◽  
Alexandra Pinggera ◽  
Amy Lee ◽  
Jörg Striessnig ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Dendritic Spine ◽  
Splice Variants ◽  
Spine Morphology ◽  
Dendritic Spine Morphology

SIRT1 Regulates Tau Expression and Tau Synaptic Pathology

2021 ◽  
pp. 1-10
Author(s):  
Xiaomin Yin ◽  
Zheng Zhou ◽  
Yanyan Qiu ◽  
Xing Fan ◽  
Chenhao Zhao ◽  
...  
Keyword(s):  
Neurofibrillary Tangles ◽  
Dendritic Spine ◽  
Amyloid Plaques ◽  
Transcriptional Level ◽  
Spine Morphology ◽  
Protein Levels ◽  
Dendritic Spine Morphology ◽  
Synaptic Pathology ◽  
Factor C ◽  
Tau Expression

Background: Amyloid plaques and neurofibrillary tangles are two pathological hallmarks of Alzheimer’s disease (AD). However, synaptic deficits occur much earlier and correlate stronger with cognitive decline than amyloid plaques and neurofibrillary tangles. Mislocalization of tau is an early hallmark of neurodegeneration and precedes aggregations. Sirtuin type 1 (SIRT1) is a deacetylase which acts on proteins including transcriptional factors and associates closely with AD. Objective: The present study investigated the association between SIRT1 and tau expression in cells and in mice brains. Methods: Western blot was performed to detected tau, SIRT1, C/EBPα, and GAPDH protein levels. Immunological fluorescence assay was used to assess tau localization in primary cortical neuronal cells. Golgi staining was performed to evaluated dendritic spine morphology in mice brains. Results: In the present study, we found that SIRT1 negatively regulates expression of tau at the transcriptional level through transcriptional factor C/EBPα. Inhibition of the activity of SIRT1 limits the distribution of tau to the neurites. In the meantime, the alteration of dendritic spine morphology is also observed in the brains of SIRT1+/– mice. Conclusion: SIRT1 may be a potential drug target for early intervention in AD.

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