A specific amyloid-β protein assembly in the brain impairs memory

Nature ◽  
2006 ◽  
Vol 440 (7082) ◽  
pp. 352-357 ◽  
Author(s):  
Sylvain Lesné ◽  
Ming Teng Koh ◽  
Linda Kotilinek ◽  
Rakez Kayed ◽  
Charles G. Glabe ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Protein Assembly ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
The Brain

Mutant Presenilin 2 Transgenic Mouse: Effect on an Age-Dependent Increase of Amyloid β-Protein 42 in the Brain

2002 ◽  
Vol 71 (1) ◽  
pp. 313-322 ◽  
Author(s):  
Fumitaka Oyama ◽  
Naoya Sawamura ◽  
Kimio Kobayashi ◽  
Maho Morishima-Kawashima ◽  
Takashi Kuramochi ◽  
...  
Keyword(s):  
Transgenic Mouse ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Age Dependent ◽  
Presenilin 2 ◽  
The Brain

Nobiletin, a flavone from Citrus depressa, induces gene expression and increases the protein level and activity of neprilysin in SK-N-SH cells

2014 ◽  
Vol 92 (5) ◽  
pp. 351-355 ◽  
Author(s):  
Hironori Fujiwara ◽  
Junko Kimura ◽  
Masahiro Sakamoto ◽  
Akihito Yokosuka ◽  
Yoshihiro Mimaki ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Time Dependent ◽  
Amyloid Β Protein ◽  
Dependent Manner ◽  
Disease Modifying Drugs ◽  
Β Protein ◽  
Gene And Protein Expression ◽  
Polymerase Chain ◽  
Potential Strategy ◽  
The Brain

Neprilysin (NEP) is one of the candidate amyloid β protein (Aβ) degrading enzymes affecting brain Aβ clearance. This enzyme declines in the brain with age, which leads to the increased Aβ deposition in Alzheimer’s disease (AD). Pharmacological activation of NEP during the aging process, therefore, represents a potential strategy to prevent the development of AD. To examine the influence of nobiletin on neprilysin activity, we measured cellular NEP activity in SK-N-SH cells. Moreover, NEP expression was examined by using reverse transcription – polymerase chain reaction and Western blotting. Measurement of cellular NEP activity showed that nobiletin stimulated this in a dose- and time-dependent manner in SK-N-SH cells. Moreover, nobiletin increased the expression of NEP mRNA, and then the levels of NEP protein, also in a dose- and time-dependent manner. Our findings showed that nobiletin promoted NEP gene and protein expression, resulting in enhancement of cellular NEP activity in SK-N-SH cells. This compound could be a novel Aβ-degrading compound for use in the development of disease-modifying drugs to prevent and (or) cure AD.

scholarly journals Amyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03

2015 ◽  
Vol 119 (14) ◽  
pp. 4831-4841 ◽  
Author(s):  
Xueyun Zheng ◽  
Deyu Liu ◽  
Frank-Gerrit Klärner ◽  
Thomas Schrader ◽  
Gal Bitan ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Protein Assembly ◽  
Amyloid Β Protein ◽  
Molecular Tweezers ◽  
Β Protein

scholarly journals Accumulation of Amyloid β-Protein in the Low-Density Membrane Domain Accurately Reflects the Extent of β-Amyloid Deposition in the Brain

2001 ◽  
Vol 158 (6) ◽  
pp. 2209-2218 ◽  
Author(s):  
Noriko Oshima ◽  
Maho Morishima-Kawashima ◽  
Haruyasu Yamaguchi ◽  
Masahiro Yoshimura ◽  
Shiro Sugihara ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Amyloid Deposition ◽  
Low Density ◽  
Amyloid Β Protein ◽  
Membrane Domain ◽  
Β Protein ◽  
Β Amyloid ◽  
The Brain

scholarly journals Inhibiting amyloid β-protein assembly: Size-activity relationships among grape seed-derived polyphenols

2015 ◽  
Vol 135 (2) ◽  
pp. 416-430 ◽  
Author(s):  
Eric Y. Hayden ◽  
Ghiam Yamin ◽  
Shiela Beroukhim ◽  
Benson Chen ◽  
Mikhail Kibalchenko ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Grape Seed ◽  
Protein Assembly ◽  
Amyloid Β Protein ◽  
Β Protein

scholarly journals Amyloid β-Protein Assembly and Alzheimer’s Disease: Dodecamers of Aβ42, but Not of Aβ40, Seed Fibril Formation

2016 ◽  
Vol 138 (6) ◽  
pp. 1772-1775 ◽  
Author(s):  
Nicholas J. Economou ◽  
Maxwell J. Giammona ◽  
Thanh D. Do ◽  
Xueyun Zheng ◽  
David B. Teplow ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Protein Assembly ◽  
Fibril Formation ◽  
Amyloid Β Protein ◽  
Β Protein

scholarly journals Dietary cis-9, trans-11-conjugated linoleic acid reduces amyloid β-protein accumulation and upregulates anti-inflammatory cytokines in an Alzheimer’s disease mouse model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yu Fujita ◽  
Kuniyuki Kano ◽  
Shigenobu Kishino ◽  
Toshihiro Nagao ◽  
Xuefeng Shen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Linoleic Acid ◽  
Mouse Model ◽  
Conjugated Linoleic Acid ◽  
Inflammatory Cytokines ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Anti Inflammatory ◽  
The Brain

AbstractConjugated linoleic acid (CLA) is an isomer of linoleic acid (LA). The predominant dietary CLA is cis-9, trans-11-CLA (c-9, t-11-CLA), which constitutes up to ~ 90% of total CLA and is thought to be responsible for the positive health benefits associated with CLA. However, the effects of c-9, t-11-CLA on Alzheimer’s disease (AD) remain to be elucidated. In this study, we investigated the effect of dietary intake of c-9, t-11-CLA on the pathogenesis of an AD mouse model. We found that c-9, t-11-CLA diet-fed AD model mice significantly exhibited (1) a decrease in amyloid-β protein (Aβ) levels in the hippocampus, (2) an increase in the number of microglia, and (3) an increase in the number of astrocytes expressing the anti-inflammatory cytokines, interleukin-10 and 19 (IL-10, IL-19), with no change in the total number of astrocytes. In addition, liquid chromatography–tandem mass spectrometry (LC–MS/MS) and gas chromatographic analysis revealed that the levels of lysophosphatidylcholine (LPC) containing c-9, t-11-CLA (CLA-LPC) and free c-9, t-11-CLA were significantly increased in the brain of c-9, t-11-CLA diet-fed mice. Thus, dietary c-9, t-11-CLA entered the brain and appeared to exhibit beneficial effects on AD, including a decrease in Aβ levels and suppression of inflammation.

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